• The Padres are -135 favorites vs the Cardinals
• Cardinals vs Padres Over / Under today: 8.5 Runs
• Cardinals / Padres TV Channel: CATV | PDTV

The St. Louis Cardinals (+110) visit Petco Park to take on the San Diego Padres (-135) on May 10, 2026. First pitch is scheduled for 4:10 pm in San Diego, CA.

This season, the Cardinals are 23-16 against the spread (ATS), while the Padres are 21-17 ATS.

Cardinals vs Padres Starting Pitchers Today:

• Cardinals starting pitcher: Kyle Leahy 4-3, 4.98 ERA
• Padres starting pitcher: Walker Buehler 2-2, 5.64 ERA

Cardinals vs. Padres Odds, Run Line, Over/Under & Moneyline

Cardinals vs Padres Prediction for Today’s Game

Based on recent trends the model predicts the Padres will win Sunday‘s MLB game with 53.3% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Cardinals vs Padres and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Cardinals players for Sunday‘s game, looking at profitable historical betting trends:

Best Cardinals Player Prop Bets Today:

• Jordan Walker has hit the Runs Over in 16 of his last 25 games (+13.10 Units / 52% ROI)
• Pedro Pages has hit the Home Runs Over in 2 of his last 10 games (+12.00 Units / 120% ROI)
• Thomas Saggese has hit the Hits Runs and RBIs Under in 19 of his last 25 games (+10.75 Units / 30% ROI)
• Ivan Herrera has hit the Total Bases Over in 11 of his last 15 games (+10.00 Units / 57% ROI)
• Thomas Saggese has hit the Hits Under in his last 6 games (+7.95 Units / 133% ROI)

And here are some favorite MLB player prop bets for Padres players for Sunday‘s game, looking at profitable historical betting trends:

Best Padres Player Prop Best Bets Today:

• Gavin Sheets has hit the Singles Under in 21 of his last 25 games at home (+14.50 Units / 38% ROI)
• Jackson Merrill has hit the Hits Runs and RBIs Under in 16 of his last 20 games (+12.45 Units / 55% ROI)
• Ramon Laureano has hit the Total Bases Under in 16 of his last 20 games (+11.50 Units / 40% ROI)
• Manny Machado has hit the Hits Under in 15 of his last 25 games (+11.40 Units / 39% ROI)
• Xander Bogaerts has hit the Home Runs Over in 2 of his last 10 games (+11.00 Units / 110% ROI)

Cardinals Best Bets Today:

• The St. Louis Cardinals have hit the Moneyline in 13 of their last 17 away games (+11.75 Units / 68% ROI)
• The St. Louis Cardinals have hit the Team Total Over in 14 of their last 18 away games (+9.55 Units / 45% ROI)
• The St. Louis Cardinals have hit the 1st Five Innings (F5) Moneyline in 12 of their last 21 games (+8.30 Units / 38% ROI)
• The St. Louis Cardinals have covered the Run Line in 17 of their last 23 games (+7.85 Units / 22% ROI)
• The St. Louis Cardinals have covered the 1st Five Innings (F5) Run Line in 15 of their last 21 games (+7.10 Units / 27% ROI)

Padres Best Bets Today:

• The San Diego Padres have covered the Run Line in 19 of their last 30 games at home (+10.60 Units / 27% ROI)
• The San Diego Padres have hit the Team Total Under in 15 of their last 20 games (+9.45 Units / 41% ROI)
• The San Diego Padres have hit the Moneyline in 31 of their last 50 games (+8.35 Units / 13% ROI)
• The San Diego Padres have hit the 1st Five Innings (F5) Moneyline in 25 of their last 45 games at home (+7.65 Units / 11% ROI)
• The San Diego Padres have covered the 1st Five Innings (F5) Run Line in 30 of their last 50 games at home (+7.50 Units / 13% ROI)

Cardinals Against the Spread (ATS) Record

Against the spread this season, the Cardinals are 24-14 against the Run Line (+3.55 Units / 6.09% ROI).

• 23-16 when betting on the Moneyline for +11.45 Units / 28.84% ROI
• 19-18 when betting on the total runs Over for -0.95 Units / -2.21% ROI
• 18-19 when betting on the total runs Under for -3.15 Units / -7.33% ROI

Padres Against the Spread (ATS) Record

Against the spread this season, the Padres are 21-17 against the Run Line (+2.8 Units / 5.47% ROI).

• 23-16 when betting on the Moneyline for +3.7 Units / 7.32% ROI
• 16-21 when betting on the total runs Over for -7 Units / -16.28% ROI
• 21-16 when betting on the total runs Under for +3.55 Units / 8.28% ROI

Padres vs Cardinals Home Run Prop Bets Today

Padres vs Cardinals Total Hits Prop Bets Today

Padres vs Cardinals Strikeout Prop Bets Today

Cardinals Keys to the Game vs. the Padres

The Cardinals are 18-1 (.947) when leading entering the 7th inning this season — 4th best in MLB; League Avg: .862.

The Cardinals are 19-1 (.950) when leading entering the 8th inning this season — tied for 5th best in MLB; League Avg: .895.

The Cardinals are 13-6 (.684) on the road this season — best in MLB; League Avg: .465.

The Cardinals are 2-14 (.125) when trailing entering the 9th inning this season — 5th best in MLB; League Avg: .051.

Padres Keys to the Game vs. the Cardinals

The Padres are 15-1 (.938) when scoring 5 or more runs this season — 3rd best in MLB; League Avg: .787.

The Padres are 20-13 (.606) when tied entering the 7th inning since the 2025 season — 5th best in MLB; League Avg: .500.

The Padres are 59-13 (.819) when they’ve had 10 or more hits since the 2025 season — 4th best in MLB; League Avg: .745.

The Padres are 14-68 (.171) when trailing entering the 7th inning since the 2025 season — 3rd best in MLB; League Avg: .127.

Cardinals Hitting Stats & Trends

Cardinals hitters have struck out in just 18% of their PA’s against LHP this season — 2nd best in MLB.

The Cardinals are batting just .206 with two outs this season — 4th lowest in MLB.

Cardinals hitters have 21 extra-base hits out of 52 total hits (40%) on the first pitch of at-bats this season — 5th best in MLB.

Cardinals hitters have put just 35% of their swings in play in non-two strike counts this season — 5th lowest in MLB.

Padres Hitting Stats & Trends

Padres hitters are slugging just .341 against LHP this season — 4th lowest in MLB.

Padres hitters are slugging just .172 on breaking pitches against LHP this season — lowest in MLB.

The Padres are batting just .209 against starting pitchers this season — lowest in MLB.

Padres hitters have an OBP of just .298 (1,147 PA’s) against RHP this season — 4th lowest in MLB.

Cardinals Pitching Stats & Trends

Cardinals pitchers have a strikeout rate of just 16% with runners in scoring position this season — lowest in MLB.

Cardinals pitchers have a strikeout rate of just 36% with two-strikes this season — lowest in MLB.

Opponents have a miss rate of just 22% against Cardinals pitchers this season — lowest in MLB.

Cardinals pitchers have a strikeout rate of just 18% this season — lowest in MLB.

Padres Pitching Stats & Trends

Opponents have a groundball rate of 48% against Padres pitchers this season — 2nd highest in MLB.

Opponents have a miss rate of 28% against Padres pitchers this season — 3rd best in MLB.

Padres pitchers have a strikeout rate of 27% when facing the leadoff batter in the inning this season — 2nd best in MLB.

Padres pitchers have a strikeout rate of 26% in late innings this season — 5th best in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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