• The Padres are -155 favorites vs the Cardinals
• Cardinals vs Padres Over / Under today: 8 Runs
• Cardinals / Padres TV Channel: ATV

The St. Louis Cardinals (+125) visit Petco Park to take on the San Diego Padres (-155) on May 8, 2026. First pitch is scheduled for 9:45 pm in San Diego, CA.

This season, the Cardinals are 22-15 against the spread (ATS), while the Padres are 20-16 ATS.

Cardinals vs Padres Starting Pitchers Today:

• Cardinals starting pitcher: Michael McGreevy 2-2, 2.58 ERA
• Padres starting pitcher: Griffin Canning 0-0, 1.93 ERA

Cardinals vs. Padres Odds, Run Line, Over/Under & Moneyline

Cardinals vs Padres Prediction for Today’s Game

Based on recent trends the model predicts the Padres will win Friday‘s MLB game with 59.1% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Cardinals vs Padres and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Cardinals players for Friday‘s game, looking at profitable historical betting trends:

Best Cardinals Player Prop Bets Today:

• Jordan Walker has hit the Runs Over in 17 of his last 25 games (+15.40 Units / 61% ROI)
• JJ Wetherholt has hit the Home Runs Over in 2 of his last 5 away games (+13.50 Units / 270% ROI)
• Masyn Winn has hit the Hits Runs and RBIs Over in 15 of his last 20 games (+12.00 Units / 58% ROI)
• Ivan Herrera has hit the Total Bases Over in 11 of his last 15 games (+9.30 Units / 53% ROI)
• Jordan Walker has hit the Hits Over in 13 of his last 15 away games (+8.65 Units / 29% ROI)

And here are some favorite MLB player prop bets for Padres players for Friday‘s game, looking at profitable historical betting trends:

Best Padres Player Prop Best Bets Today:

• Gavin Sheets has hit the Singles Under in 21 of his last 25 games at home (+14.50 Units / 37% ROI)
• Miguel Andujar has hit the Home Runs Over in 2 of his last 5 games at home (+12.50 Units / 250% ROI)
• Fernando Tatis Jr. has hit the RBIs Under in 14 of his last 15 games (+11.85 Units / 40% ROI)
• Manny Machado has hit the Hits Under in 13 of his last 20 games (+11.05 Units / 46% ROI)
• Ramon Laureano has hit the Total Bases Under in 13 of his last 15 games (+10.50 Units / 48% ROI)

Cardinals Best Bets Today:

• The St. Louis Cardinals have hit the Moneyline in 28 of their last 50 games (+11.80 Units / 23% ROI)
• The St. Louis Cardinals have hit the Team Total Over in 13 of their last 16 away games (+9.70 Units / 51% ROI)
• The St. Louis Cardinals have covered the Run Line in 16 of their last 21 games (+8.65 Units / 27% ROI)
• The St. Louis Cardinals have hit the 1st Five Innings (F5) Moneyline in 11 of their last 19 games (+8.15 Units / 42% ROI)
• The St. Louis Cardinals have covered the 1st Five Innings (F5) Run Line in 14 of their last 19 games (+7.50 Units / 31% ROI)

Padres Best Bets Today:

• The San Diego Padres have hit the 1st Five Innings (F5) Moneyline in 26 of their last 45 games at home (+10.10 Units / 15% ROI)
• The San Diego Padres have covered the Run Line in 19 of their last 30 games at home (+9.75 Units / 25% ROI)
• The San Diego Padres have covered the 1st Five Innings (F5) Run Line in 31 of their last 50 games at home (+9.65 Units / 16% ROI)
• The San Diego Padres have hit the Team Total Under in 14 of their last 18 games (+9.30 Units / 44% ROI)
• The San Diego Padres have hit the Moneyline in 20 of their last 30 games (+7.65 Units / 19% ROI)

Cardinals Against the Spread (ATS) Record

Against the spread this season, the Cardinals are 23-13 against the Run Line (+4.35 Units / 7.95% ROI).

• 22-15 when betting on the Moneyline for +11.2 Units / 29.71% ROI
• 19-16 when betting on the total runs Over for +1.35 Units / 3.33% ROI
• 16-19 when betting on the total runs Under for -5.15 Units / -12.59% ROI

Padres Against the Spread (ATS) Record

Against the spread this season, the Padres are 20-16 against the Run Line (+2.25 Units / 4.58% ROI).

• 22-15 when betting on the Moneyline for +4.15 Units / 8.7% ROI
• 16-19 when betting on the total runs Over for -4.7 Units / -11.55% ROI
• 19-16 when betting on the total runs Under for +1.55 Units / 3.8% ROI

Padres vs Cardinals Home Run Prop Bets Today

Padres vs Cardinals Total Hits Prop Bets Today

Padres vs Cardinals Strikeout Prop Bets Today

Cardinals Keys to the Game vs. the Padres

The Cardinals are 12-5 (.706) on the road this season — best in MLB; League Avg: .467.

The Cardinals are 13-8 (.619) after a win this season — 4th best in MLB; League Avg: .528.

The Cardinals are 17-1 (.944) when leading entering the 7th inning this season — 5th best in MLB; League Avg: .860.

The Cardinals are 2-13 (.133) when trailing entering the 9th inning this season — 5th best in MLB; League Avg: .053.

Padres Keys to the Game vs. the Cardinals

The Padres are 15-1 (.938) when scoring 5 or more runs this season — 3rd best in MLB; League Avg: .785.

The Padres are 78-7 (.918) when leading entering the 7th inning since the 2025 season — 3rd best in MLB; League Avg: .872.

The Padres are 49-37 (.570) after a loss since the 2025 season — tied for 2nd best in MLB; League Avg: .481.

The Padres are 14-67 (.173) when trailing entering the 7th inning since the 2025 season — 3rd best in MLB; League Avg: .127.

Cardinals Hitting Stats & Trends

Cardinals hitters have struck out in just 18% of their PA’s against LHP this season — 3rd best in MLB.

The Cardinals are batting just .218 when facing the starting pitcher for the 3rd time in a game this season — 4th lowest in MLB.

Cardinals hitters have an OPS of .784 (452 PA’s) in innings 7-9 this season — 5th best in MLB.

The Cardinals are batting just .212 with two outs this season — 4th lowest in MLB.

Padres Hitting Stats & Trends

Padres hitters are slugging just .172 on breaking pitches against LHP this season — lowest in MLB.

Padres hitters are slugging .285 with two-strikes this season — tied for 4th best in MLB.

Padres hitters have an OBP of just .304 (1,369 PA’s) this season — 5th lowest in MLB.

The Padres are batting .377 on the first pitch of at-bats this season — 2nd best in MLB.

Cardinals Pitching Stats & Trends

Cardinals pitchers have a strikeout rate of just 35% with two-strikes this season — lowest in MLB.

Cardinals pitchers have a strikeout rate of just 16% with runners in scoring position this season — lowest in MLB.

Opponents have a miss rate of just 21% against Cardinals pitchers this season — lowest in MLB.

Cardinals pitchers have a strikeout rate of just 18% this season — lowest in MLB.

Padres Pitching Stats & Trends

Opponents have a miss rate of 28% against Padres pitchers this season — 3rd best in MLB.

Opponents have a groundball rate of 47% against Padres pitchers this season — tied for 3rd highest in MLB.

Opponents have a Hard-Hit Avg of just 36% against the Padres pitchers this season — 2nd best in MLB.

Padres pitchers have a strikeout rate of 27% when facing the leadoff batter in the inning this season — 2nd best in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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