• The Padres are -150 favorites vs the Cardinals
• Cardinals vs Padres Over / Under today: 8 Runs
• Cardinals / Padres TV Channel: FOX

The St. Louis Cardinals (+125) visit Petco Park to take on the San Diego Padres (-150) on May 9, 2026. First pitch is scheduled for 7:15 pm in San Diego, CA.

This season, the Cardinals are 23-15 against the spread (ATS), while the Padres are 20-17 ATS.

Cardinals vs Padres Starting Pitchers Today:

• Cardinals starting pitcher: Dustin May 3-3, 5.35 ERA
• Padres starting pitcher: Randy Vasquez 3-1, 3.21 ERA

Cardinals vs. Padres Odds, Run Line, Over/Under & Moneyline

Cardinals vs Padres Prediction for Today’s Game

Based on recent trends the model predicts the Padres will win Saturday‘s MLB game with 57.4% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Cardinals vs Padres and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Cardinals players for Saturday‘s game, looking at profitable historical betting trends:

Best Cardinals Player Prop Bets Today:

• Jordan Walker has hit the Runs Over in 16 of his last 25 games (+13.25 Units / 53% ROI)
• Pedro Pages has hit the Home Runs Over in 2 of his last 9 games (+13.00 Units / 144% ROI)
• Masyn Winn has hit the Hits Runs and RBIs Over in 15 of his last 20 games (+12.30 Units / 59% ROI)
• Alec Burleson has hit the Total Bases Over in 16 of his last 25 away games (+10.75 Units / 42% ROI)
• Masyn Winn has hit the Hits Over in 16 of his last 20 games (+8.65 Units / 24% ROI)

And here are some favorite MLB player prop bets for Padres players for Saturday‘s game, looking at profitable historical betting trends:

Best Padres Player Prop Best Bets Today:

• Gavin Sheets has hit the Singles Under in 21 of his last 25 games at home (+14.50 Units / 38% ROI)
• Xander Bogaerts has hit the Home Runs Over in 2 of his last 9 games (+12.00 Units / 133% ROI)
• Fernando Tatis Jr. has hit the RBIs Under in 14 of his last 15 games (+11.85 Units / 40% ROI)
• Jackson Merrill has hit the Hits Runs and RBIs Under in 15 of his last 20 games (+10.40 Units / 46% ROI)
• Freddy Fermin has hit the Hits Under in 11 of his last 15 games (+9.95 Units / 62% ROI)

Cardinals Best Bets Today:

• The St. Louis Cardinals have hit the Moneyline in 13 of their last 16 away games (+12.75 Units / 78% ROI)
• The St. Louis Cardinals have hit the Team Total Over in 14 of their last 17 away games (+10.70 Units / 53% ROI)
• The St. Louis Cardinals have covered the Run Line in 17 of their last 22 games (+9.65 Units / 29% ROI)
• The St. Louis Cardinals have hit the 1st Five Innings (F5) Moneyline in 12 of their last 20 games (+9.30 Units / 45% ROI)
• The St. Louis Cardinals have covered the 1st Five Innings (F5) Run Line in 15 of their last 20 games (+8.50 Units / 34% ROI)

Padres Best Bets Today:

• The San Diego Padres have hit the Team Total Under in 15 of their last 19 games (+10.45 Units / 48% ROI)
• The San Diego Padres have covered the Run Line in 18 of their last 30 games at home (+7.75 Units / 20% ROI)
• The San Diego Padres have hit the 1st Five Innings (F5) Moneyline in 25 of their last 45 games at home (+7.65 Units / 11% ROI)
• The San Diego Padres have covered the 1st Five Innings (F5) Run Line in 30 of their last 50 games at home (+7.40 Units / 12% ROI)
• The San Diego Padres have hit the Game Total Under in 28 of their last 50 games (+6.15 Units / 11% ROI)

Cardinals Against the Spread (ATS) Record

Against the spread this season, the Cardinals are 24-13 against the Run Line (+5.35 Units / 9.48% ROI).

• 23-15 when betting on the Moneyline for +12.45 Units / 32.17% ROI
• 19-17 when betting on the total runs Over for +0.25 Units / 0.6% ROI
• 17-19 when betting on the total runs Under for -4.15 Units / -9.88% ROI

Padres Against the Spread (ATS) Record

Against the spread this season, the Padres are 20-17 against the Run Line (+1.25 Units / 2.49% ROI).

• 22-16 when betting on the Moneyline for +2.7 Units / 5.49% ROI
• 16-20 when betting on the total runs Over for -5.8 Units / -13.88% ROI
• 20-16 when betting on the total runs Under for +2.55 Units / 6.09% ROI

Padres vs Cardinals Home Run Prop Bets Today

Padres vs Cardinals Total Hits Prop Bets Today

Padres vs Cardinals Strikeout Prop Bets Today

Cardinals Keys to the Game vs. the Padres

The Cardinals are 13-5 (.722) on the road this season — best in MLB; League Avg: .469.

The Cardinals are 18-1 (.947) when leading entering the 7th inning this season — 5th best in MLB; League Avg: .862.

The Cardinals are 2-13 (.133) when trailing entering the 9th inning this season — 5th best in MLB; League Avg: .052.

The Cardinals are 14-8 (.636) after a win this season — 4th best in MLB; League Avg: .531.

Padres Keys to the Game vs. the Cardinals

The Padres are just 3-8 (.273) vs top 10 scoring offenses this season Today, they face the Cardinals (10th in runs scored).

The Padres are 15-1 (.938) when scoring 5 or more runs this season — 3rd best in MLB; League Avg: .785.

The Padres are 13-7 (.650) when tied entering the 8th inning since the 2025 season — 5th best in MLB; League Avg: .500.

The Padres are 14-68 (.171) when trailing entering the 7th inning since the 2025 season — 3rd best in MLB; League Avg: .127.

Cardinals Hitting Stats & Trends

Cardinals hitters have struck out in just 18% of their PA’s against LHP this season — 2nd best in MLB.

The Cardinals are batting just .207 with two outs this season — 4th lowest in MLB.

Cardinals hitters have 21 extra-base hits out of 52 total hits (40%) on the first pitch of at-bats this season — 5th best in MLB.

Cardinals hitters have an OPS of .777 (465 PA’s) in innings 7-9 this season — 5th best in MLB.

Padres Hitting Stats & Trends

Padres hitters have an OBP of just .278 (779 PA’s) against starting pitchers this season — lowest in MLB.

Padres hitters have an OBP of just .299 (1,399 PA’s) this season — 3rd lowest in MLB.

The Padres are batting just .211 against starting pitchers this season — lowest in MLB.

Padres hitters are slugging just .172 on breaking pitches against LHP this season — lowest in MLB.

Cardinals Pitching Stats & Trends

Opponents have a miss rate of just 21% against Cardinals pitchers this season — lowest in MLB.

Cardinals pitchers have a strikeout rate of just 16% with runners in scoring position this season — lowest in MLB.

Cardinals pitchers have a strikeout rate of just 18% this season — lowest in MLB.

Cardinals pitchers have a strikeout rate of just 36% with two-strikes this season — lowest in MLB.

Padres Pitching Stats & Trends

Opponents have a groundball rate of 48% against Padres pitchers this season — tied for highest in MLB.

Opponents have a miss rate of 28% against Padres pitchers this season — 3rd best in MLB.

Opponents have a groundball batting average of .307 against Padres pitchers with runners on base this season — 2nd highest in MLB.

Padres pitchers have a strikeout rate of 27% when facing the leadoff batter in the inning this season — 2nd best in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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