Cardinals vs Padres Prediction, Odds & Player Prop Bets Today – MLB, Sep 21

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MLB betting odds, predictions and betting odds for today's games
(AP Photo)
BetMGM Betting @BETMGM Sep 21, 2022, 3:30 PM
  • The Padres (82-66) are -135 favorites vs the Cardinals (87-62)
  • Cardinals starting pitcher: Miles Mikolas (11-12), 3.45 ERA
  • Padres starting pitcher: Blake Snell (7-9), 3.84 ERA
  • Watch the game on MLB Network

The St. Louis Cardinals (+110) visit PETCO Park to take on the San Diego Padres (-135) on Wednesday, September 21, 2022. First pitch is scheduled for 9:40pm EDT in San Diego.

The Padres are betting favorites in this MLB matchup, with the run line sitting at -1.5 (+155).

The Cardinals vs Padres Over/Under is 7.5 total runs for the game.

So far this season, the Cardinals are 84-62 against the spread (ATS), while the Padres are 65-79 ATS.

Cardinals vs. Padres Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Cardinals+1.5 -190O 7.5 -110+110
Padres -1.5 +155U 7.5 -110-135

Cardinals vs Padres Prediction for Today’s Game

Based on recent trends the model predicts the Cardinals will win Wednesday‘s matchup with 51.0% confidence.

This prediction factors in starting pitchers, recent team and player hitting performances, the last 5 games for both the Cardinals and Padres and up-to-date player injuries.


Looking for a risk-free bet up to $1,000? Bet now on Padres vs Cardinals and all MLB games with BetMGM


Best Cardinals Player Prop Bets Today

We’ve highlighted some favorite MLB player prop bets for Cardinals players for Wednesday‘s game, looking at profitable historical betting trends:

  • Jose Quintana has hit the Earned Runs Under in 19 of his last 24 games (+13.30 Units / 46% ROI)
  • Tommy Edman has hit the Total Bases Over in 15 of his last 20 games (+11.45 Units / 46% ROI)
  • Tommy Edman has hit the Hits Over in 16 of his last 20 games (+11.10 Units / 30% ROI)
  • Brendan Donovan has hit the Total Bases Under in 19 of his last 27 away games (+9.60 Units / 22% ROI)
  • Corey Dickerson has hit the Total Bases Over in 11 of his last 14 away games (+9.50 Units / 55% ROI)

Best Padres Player Prop Best Bets Today

And here are some favorite MLB player prop bets for Padres players for Wednesday‘s game, looking at profitable historical betting trends:

  • Juan Soto has hit the Hits Under in 19 of his last 29 games (+14.90 Units / 49% ROI)
  • Josh Bell has hit the Hits Over in 26 of his last 34 games at home (+14.70 Units / 21% ROI)
  • Yu Darvish has hit the Pitching Outs Over in 20 of his last 26 games (+13.90 Units / 43% ROI)
  • Jake Cronenworth has hit the Hits Over in 23 of his last 29 games (+11.40 Units / 19% ROI)
  • Manny Machado has hit the Singles Under in 23 of his last 33 games at home (+10.55 Units / 25% ROI)

Padres vs Cardinals Home Run Prop Bets Today

Over Under
Austin Nola 0.5 +800 0.5 -3000
Brandon Drury 0.5 +475 0.5 -1100
Ha-seong Kim 0.5 +775 0.5 -3000
Jake Cronenworth 0.5 +600 0.5 -1600
Jose Azocar 0.5 +825 0.5 -5000

Padres vs Cardinals Total Hits Prop Bets Today

Over Under
Austin Nola 0.5 -160 0.5 +110
Brandon Drury 0.5 -200 0.5 +150
Ha-seong Kim 0.5 -165 0.5 +115
Jake Cronenworth 0.5 -225 0.5 +160
Jose Azocar 0.5 -165 0.5 +120

Padres vs Cardinals RBI Prop Bets Today

Over Under
Austin Nola 0.5 +240 0.5 -350
Brandon Drury 0.5 +130 0.5 -190
Ha-seong Kim 0.5 +195 0.5 -300
Jake Cronenworth 0.5 +175 0.5 -250
Jose Azocar 0.5 +260 0.5 -400

Padres vs Cardinals Strikeout Prop Bets Today

Over Under
Blake Snell 6.5 +110 6.5 -160
Miles Mikolas 3.5 -115 3.5 -120
  • The St. Louis Cardinals have hit the 1st Five Innings (F5) Total Over in 33 of their last 60 away games (+8.75 Units / 13% ROI)
  • The St. Louis Cardinals have hit the Game Total Under in 6 of their last 7 games (+4.80 Units / 60% ROI)
  • The San Diego Padres have hit the 1st Five Innings (F5) Total Over in 14 of their last 23 games (+7.70 Units / 30% ROI)
  • The San Diego Padres have covered the 1st Five Innings (F5) Run Line in 8 of their last 11 games (+5.15 Units / 39% ROI)
  • The San Diego Padres have hit the Game Total Under in 6 of their last 7 games (+5.05 Units / 67% ROI)
  • The San Diego Padres have covered the Run Line in 4 of their last 5 games (+3.80 Units / 59% ROI)
  • The San Diego Padres have hit the Moneyline in 8 of their last 12 games (+3.80 Units / 23% ROI)

Cardinals Against the Spread (ATS) Record

Against the spread this MLB season, the Cardinals have gone 79-67 against the Run Line (+7.3 Units / 4.01% ROI).

  • 84-62 when betting on the Moneyline for +4.65 Units / 2.2% ROI
  • 67-73 when betting on the total runs Over for -13.6 Units / -8.5% ROI
  • 73-67 when betting on the total runs Under for -0.25 Units / -0.16% ROI

Padres Against the Spread (ATS) Record

Against the spread this MLB season, the Cardinals have gone 65-79 against the Run Line (-18.9 Units / -10.58% ROI).

  • 80-65 when betting on the Moneyline for -7.95 Units / -3.72% ROI
  • 69-72 when betting on the total runs Over for -9.4 Units / -5.92% ROI
  • 72-69 when betting on the total runs Under for -3.8 Units / -2.36% ROI

Miles Mikolas has a strikeout rate of just 17% (29 SO in 172 PAs) on low non-fastballs this season — tied for lowest among qualified SPs in MLB; League Avg: 35% — fourth Percentile.

Opponents have a two strike miss rate of just 16% (89/554) against Miles Mikolas this season — 3rd lowest among qualified SPs in MLB; League Avg: 25% — sixth Percentile.

Miles Mikolas has thrown inside pitches 46% of the time (634/1,377) vs left-handed batters this season — 2nd highest among qualified SPs in MLB; League Avg: 33% — 96th Percentile.

Right-handed hitters have a miss rate of just 20% (152/756) against Miles Mikolas this season — 4th lowest among qualified SPs in MLB; League Avg: 26% — eighth Percentile.

Blake Snell: Padres Starting Pitcher Stats & Trends

Blake Snell has walked 44 of 262 batters (17%) with runners in scoring position since the start of last season — highest in MLB among starting pitchers with at least 154 total IP; League Avg: 9% — 0 Percentile.

Blake Snell has walked 96 of 806 right-handed batters (12%) since the start of last season — highest in MLB among starting pitchers with at least 154 total IP; League Avg: 7% — 0 Percentile.

Blake Snell has allowed an average Exit Velocity of 85.7 MPH on pitches out of the zone since the start of last season (117 balls in play) — highest in MLB among starting pitchers with at least 152 total IP; League Avg: 80.3

Blake Snell allowed an OBP of just .100 (20 PA’s) against right-handed batters — best in MLB over the last week; League Avg: .288 — 100th Percentile.

Cardinals Keys to the Game vs. the Padres

The Cardinals are 15-4 (.789) when tied entering the 8th inning this season — best in MLB; League Avg: .500.

The Cardinals are 51-27 (.654) at home this season — 6th best in MLB; League Avg: .527.

The Cardinals are 35-13 (.729) when scoring in the first inning this season — 10th best in MLB; League Avg: .666.

The Cardinals are 72-21 (.774) when allowing 4 or fewer runs this season — 7th best in MLB; League Avg: .705.

Padres Keys to the Game vs. the Cardinals

The Padres are 27-9 (.750) when scoring in the first inning this season — 8th best in MLB; League Avg: .666.

The Padres are 67-21 (.761) when allowing 4 or fewer runs this season — 8th best in MLB; League Avg: .705.

The Padres are 29-8 (.784) when hitting 2 or more home runs this season — 8th best in MLB; League Avg: .710.

The Padres are 20-2 (.909) when totaling 5 or more extra base hits this season — 4th best in MLB; League Avg: .802.

Cardinals hitters have 247 extra-base hits out of 573 total hits (43%) against LHP since the start of last season — best in MLB; League Avg: 35%.

Cardinals hitters are slugging .472 against LHP since the start of last season — best in MLB; League Avg: .408.

Cardinals hitters have an OPS of .808 (2,485 PA’s) against LHP since the start of last season — best in MLB; League Avg: .726.

Cardinals hitters have an OPS of 1.022 (83 PA’s) against LHP this month (11 games) — best in MLB; League Avg: .713.

Padres hitters have a swing rate of just 58% with two-strikes since the start of last season — lowest in MLB; League Avg: 61%.

Padres hitters are slugging .229 on pitches out of the zone since the start of last season — tied for 3rd best in MLB; League Avg: .211.

Padres hitters are slugging just .383 against LHP since the start of last season — tied for 4th lowest in MLB; League Avg: .408.

Padres hitters have an OBP of .325 (3,090 PA’s) on the road this season — 5th best in MLB; League Avg: .308.

Opponents have a groundball rate of 48% against Cardinals pitchers this season — 2nd highest in MLB; League Avg: 43%.

Opponents have a groundball rate of 46% against Cardinals pitchers since the start of last season — 2nd highest in MLB; League Avg: 43%.

Opponents have a miss rate of just 22% against Cardinals pitchers this season — lowest in MLB; League Avg: 26%.

In games when their opponents have scored three or more runs in an inning, the Cardinals have have still managed to win 52% of the time at home this season — highest in MLB; League Avg: 25%.

Opponents have a groundball rate of just 36% against Padres pitchers this month (16 games) — 2nd lowest in MLB; League Avg: 43%.

Padres pitchers have walked 78 of 1,320 batters (6%) when facing the leadoff batter in the inning this season — 3rd best in MLB; League Avg: 7%.

Padres pitchers have walked 6 of 199 batters (3%) over the past seven days (6 games) — best in MLB; League Avg: 8%.

Opponents have a groundball batting average of just .195 against Padres pitchers with the shift since the start of last season — best in MLB; League Avg: .223.

Padres vs. Cardinals Injuries Tonight That May Affect Prop Bets 

  • Thomas Pomeranz (Padres): Elbow, D60
  • Austin Adams (Padres): Forearm, D60
  • Alexander Reyes (Cardinals): Shoulder, D60
  • Tyler O’Neill (Cardinals): Hamstring, D10
  • Jordan Hicks (Cardinals): Neck, D15
  • Drew VerHagen (Cardinals): Hip, D60

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Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.