- The Padres (82-66) are -135 favorites vs the Cardinals (87-62)
- Cardinals starting pitcher: Miles Mikolas (11-12), 3.45 ERA
- Padres starting pitcher: Blake Snell (7-9), 3.84 ERA
- Watch the game on MLB Network
The St. Louis Cardinals (+110) visit PETCO Park to take on the San Diego Padres (-135) on Wednesday, September 21, 2022. First pitch is scheduled for 9:40pm EDT in San Diego.
The Padres are betting favorites in this MLB matchup, with the run line sitting at -1.5 (+155).
The Cardinals vs Padres Over/Under is 7.5 total runs for the game.
So far this season, the Cardinals are 84-62 against the spread (ATS), while the Padres are 65-79 ATS.
Cardinals vs. Padres Odds, Run Line, Over/Under & Moneyline
| Spread | Over / Under | Moneyline | |
| Cardinals | +1.5 -190 | O 7.5 -110 | +110 |
| Padres | -1.5 +155 | U 7.5 -110 | -135 |
Cardinals vs Padres Prediction for Today’s Game
Based on recent trends the model predicts the Cardinals will win Wednesday‘s matchup with 51.0% confidence.
This prediction factors in starting pitchers, recent team and player hitting performances, the last 5 games for both the Cardinals and Padres and up-to-date player injuries.
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Best Cardinals Player Prop Bets Today
We’ve highlighted some favorite MLB player prop bets for Cardinals players for Wednesday‘s game, looking at profitable historical betting trends:
- Jose Quintana has hit the Earned Runs Under in 19 of his last 24 games (+13.30 Units / 46% ROI)
- Tommy Edman has hit the Total Bases Over in 15 of his last 20 games (+11.45 Units / 46% ROI)
- Tommy Edman has hit the Hits Over in 16 of his last 20 games (+11.10 Units / 30% ROI)
- Brendan Donovan has hit the Total Bases Under in 19 of his last 27 away games (+9.60 Units / 22% ROI)
- Corey Dickerson has hit the Total Bases Over in 11 of his last 14 away games (+9.50 Units / 55% ROI)
Best Padres Player Prop Best Bets Today
And here are some favorite MLB player prop bets for Padres players for Wednesday‘s game, looking at profitable historical betting trends:
- Juan Soto has hit the Hits Under in 19 of his last 29 games (+14.90 Units / 49% ROI)
- Josh Bell has hit the Hits Over in 26 of his last 34 games at home (+14.70 Units / 21% ROI)
- Yu Darvish has hit the Pitching Outs Over in 20 of his last 26 games (+13.90 Units / 43% ROI)
- Jake Cronenworth has hit the Hits Over in 23 of his last 29 games (+11.40 Units / 19% ROI)
- Manny Machado has hit the Singles Under in 23 of his last 33 games at home (+10.55 Units / 25% ROI)
Padres vs Cardinals Home Run Prop Bets Today
| Over | Under | |
|---|---|---|
| Austin Nola | 0.5 +800 | 0.5 -3000 |
| Brandon Drury | 0.5 +475 | 0.5 -1100 |
| Ha-seong Kim | 0.5 +775 | 0.5 -3000 |
| Jake Cronenworth | 0.5 +600 | 0.5 -1600 |
| Jose Azocar | 0.5 +825 | 0.5 -5000 |
Padres vs Cardinals Total Hits Prop Bets Today
| Over | Under | |
|---|---|---|
| Austin Nola | 0.5 -160 | 0.5 +110 |
| Brandon Drury | 0.5 -200 | 0.5 +150 |
| Ha-seong Kim | 0.5 -165 | 0.5 +115 |
| Jake Cronenworth | 0.5 -225 | 0.5 +160 |
| Jose Azocar | 0.5 -165 | 0.5 +120 |
Padres vs Cardinals RBI Prop Bets Today
| Over | Under | |
|---|---|---|
| Austin Nola | 0.5 +240 | 0.5 -350 |
| Brandon Drury | 0.5 +130 | 0.5 -190 |
| Ha-seong Kim | 0.5 +195 | 0.5 -300 |
| Jake Cronenworth | 0.5 +175 | 0.5 -250 |
| Jose Azocar | 0.5 +260 | 0.5 -400 |
Padres vs Cardinals Strikeout Prop Bets Today
| Over | Under | |
|---|---|---|
| Blake Snell | 6.5 +110 | 6.5 -160 |
| Miles Mikolas | 3.5 -115 | 3.5 -120 |
Positive Betting Trends for the Cardinals Run Line, Moneyline, Run Totals
- The St. Louis Cardinals have hit the 1st Five Innings (F5) Total Over in 33 of their last 60 away games (+8.75 Units / 13% ROI)
- The St. Louis Cardinals have hit the Game Total Under in 6 of their last 7 games (+4.80 Units / 60% ROI)
Positive Betting Trends for the Padres: Run Line, Moneyline, Run Totals
- The San Diego Padres have hit the 1st Five Innings (F5) Total Over in 14 of their last 23 games (+7.70 Units / 30% ROI)
- The San Diego Padres have covered the 1st Five Innings (F5) Run Line in 8 of their last 11 games (+5.15 Units / 39% ROI)
- The San Diego Padres have hit the Game Total Under in 6 of their last 7 games (+5.05 Units / 67% ROI)
- The San Diego Padres have covered the Run Line in 4 of their last 5 games (+3.80 Units / 59% ROI)
- The San Diego Padres have hit the Moneyline in 8 of their last 12 games (+3.80 Units / 23% ROI)
Cardinals Against the Spread (ATS) Record
Against the spread this MLB season, the Cardinals have gone 79-67 against the Run Line (+7.3 Units / 4.01% ROI).
- 84-62 when betting on the Moneyline for +4.65 Units / 2.2% ROI
- 67-73 when betting on the total runs Over for -13.6 Units / -8.5% ROI
- 73-67 when betting on the total runs Under for -0.25 Units / -0.16% ROI
Padres Against the Spread (ATS) Record
Against the spread this MLB season, the Cardinals have gone 65-79 against the Run Line (-18.9 Units / -10.58% ROI).
- 80-65 when betting on the Moneyline for -7.95 Units / -3.72% ROI
- 69-72 when betting on the total runs Over for -9.4 Units / -5.92% ROI
- 72-69 when betting on the total runs Under for -3.8 Units / -2.36% ROI
Miles Mikolas: Cardinals Starting Pitcher Stats & Trends
Miles Mikolas has a strikeout rate of just 17% (29 SO in 172 PAs) on low non-fastballs this season — tied for lowest among qualified SPs in MLB; League Avg: 35% — fourth Percentile.
Opponents have a two strike miss rate of just 16% (89/554) against Miles Mikolas this season — 3rd lowest among qualified SPs in MLB; League Avg: 25% — sixth Percentile.
Miles Mikolas has thrown inside pitches 46% of the time (634/1,377) vs left-handed batters this season — 2nd highest among qualified SPs in MLB; League Avg: 33% — 96th Percentile.
Right-handed hitters have a miss rate of just 20% (152/756) against Miles Mikolas this season — 4th lowest among qualified SPs in MLB; League Avg: 26% — eighth Percentile.
Blake Snell: Padres Starting Pitcher Stats & Trends
Blake Snell has walked 44 of 262 batters (17%) with runners in scoring position since the start of last season — highest in MLB among starting pitchers with at least 154 total IP; League Avg: 9% — 0 Percentile.
Blake Snell has walked 96 of 806 right-handed batters (12%) since the start of last season — highest in MLB among starting pitchers with at least 154 total IP; League Avg: 7% — 0 Percentile.
Blake Snell has allowed an average Exit Velocity of 85.7 MPH on pitches out of the zone since the start of last season (117 balls in play) — highest in MLB among starting pitchers with at least 152 total IP; League Avg: 80.3
Blake Snell allowed an OBP of just .100 (20 PA’s) against right-handed batters — best in MLB over the last week; League Avg: .288 — 100th Percentile.
Cardinals Keys to the Game vs. the Padres
The Cardinals are 15-4 (.789) when tied entering the 8th inning this season — best in MLB; League Avg: .500.
The Cardinals are 51-27 (.654) at home this season — 6th best in MLB; League Avg: .527.
The Cardinals are 35-13 (.729) when scoring in the first inning this season — 10th best in MLB; League Avg: .666.
The Cardinals are 72-21 (.774) when allowing 4 or fewer runs this season — 7th best in MLB; League Avg: .705.
Padres Keys to the Game vs. the Cardinals
The Padres are 27-9 (.750) when scoring in the first inning this season — 8th best in MLB; League Avg: .666.
The Padres are 67-21 (.761) when allowing 4 or fewer runs this season — 8th best in MLB; League Avg: .705.
The Padres are 29-8 (.784) when hitting 2 or more home runs this season — 8th best in MLB; League Avg: .710.
The Padres are 20-2 (.909) when totaling 5 or more extra base hits this season — 4th best in MLB; League Avg: .802.
Cardinals Hitting Stats & Trends
Cardinals hitters have 247 extra-base hits out of 573 total hits (43%) against LHP since the start of last season — best in MLB; League Avg: 35%.
Cardinals hitters are slugging .472 against LHP since the start of last season — best in MLB; League Avg: .408.
Cardinals hitters have an OPS of .808 (2,485 PA’s) against LHP since the start of last season — best in MLB; League Avg: .726.
Cardinals hitters have an OPS of 1.022 (83 PA’s) against LHP this month (11 games) — best in MLB; League Avg: .713.
Padres Hitting Stats & Trends
Padres hitters have a swing rate of just 58% with two-strikes since the start of last season — lowest in MLB; League Avg: 61%.
Padres hitters are slugging .229 on pitches out of the zone since the start of last season — tied for 3rd best in MLB; League Avg: .211.
Padres hitters are slugging just .383 against LHP since the start of last season — tied for 4th lowest in MLB; League Avg: .408.
Padres hitters have an OBP of .325 (3,090 PA’s) on the road this season — 5th best in MLB; League Avg: .308.
Cardinals Pitching Stats & Trends
Opponents have a groundball rate of 48% against Cardinals pitchers this season — 2nd highest in MLB; League Avg: 43%.
Opponents have a groundball rate of 46% against Cardinals pitchers since the start of last season — 2nd highest in MLB; League Avg: 43%.
Opponents have a miss rate of just 22% against Cardinals pitchers this season — lowest in MLB; League Avg: 26%.
In games when their opponents have scored three or more runs in an inning, the Cardinals have have still managed to win 52% of the time at home this season — highest in MLB; League Avg: 25%.
Padres Pitching Stats & Trends
Opponents have a groundball rate of just 36% against Padres pitchers this month (16 games) — 2nd lowest in MLB; League Avg: 43%.
Padres pitchers have walked 78 of 1,320 batters (6%) when facing the leadoff batter in the inning this season — 3rd best in MLB; League Avg: 7%.
Padres pitchers have walked 6 of 199 batters (3%) over the past seven days (6 games) — best in MLB; League Avg: 8%.
Opponents have a groundball batting average of just .195 against Padres pitchers with the shift since the start of last season — best in MLB; League Avg: .223.
Padres vs. Cardinals Injuries Tonight That May Affect Prop Bets
- Thomas Pomeranz (Padres): Elbow, D60
- Austin Adams (Padres): Forearm, D60
- Alexander Reyes (Cardinals): Shoulder, D60
- Tyler O’Neill (Cardinals): Hamstring, D10
- Jordan Hicks (Cardinals): Neck, D15
- Drew VerHagen (Cardinals): Hip, D60
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