• The Phillies are -220 favorites vs the Cardinals
• Cardinals vs Phillies Over / Under today: 8 Runs
• Cardinals / Phillies TV Channel: CATV | NSPA

The St. Louis Cardinals (+180) visit Citizens Bank Park to take on the Philadelphia Phillies (-220) on August 21, 2026. First pitch is scheduled for 6:40 pm in Philadelphia, PA.

This season, the Cardinals are 66-63 against the spread (ATS), while the Phillies are 51-76 ATS.

Cardinals vs Phillies Starting Pitchers Today:

• Cardinals starting pitcher: Undecided 0-0, 0.00 ERA
• Phillies starting pitcher: Jesus Luzardo 11-5, 3.25 ERA

Cardinals vs. Phillies Odds, Run Line, Over/Under & Moneyline

Cardinals vs Phillies Prediction for Today’s Game

Based on recent trends the model predicts the Cardinals will win Friday‘s MLB game with 51.0% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Cardinals vs Phillies and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Cardinals players for Friday‘s game, looking at profitable historical betting trends:

Best Cardinals Player Prop Bets Today:

• Masyn Winn has hit the Total Bases Under in 14 of his last 20 away games (+10.60 Units / 41% ROI)
• Alec Burleson has hit the Hits Over in 17 of his last 25 away games (+10.25 Units / 24% ROI)
• Blaze Jordan has hit the Runs Under in 17 of his last 20 games (+9.80 Units / 21% ROI)
• Jordan Walker has hit the Home Runs Over in 3 of his last 6 games (+9.20 Units / 153% ROI)
• Jimmy Crooks III has hit the Hits Runs and RBIs Under in 17 of his last 25 games (+9.00 Units / 29% ROI)

And here are some favorite MLB player prop bets for Phillies players for Friday‘s game, looking at profitable historical betting trends:

Best Phillies Player Prop Best Bets Today:

• Luis Arraez has hit the Home Runs Over in 2 of his last 8 games at home (+15.00 Units / 188% ROI)
• Bryce Harper has hit the Walks Over in 14 of his last 15 games (+14.65 Units / 96% ROI)
• Luis Arraez has hit the Hits Runs and RBIs Over in 19 of his last 25 games at home (+11.70 Units / 34% ROI)
• Luis Arraez has hit the Hits Over in 14 of his last 25 games at home (+11.65 Units / 47% ROI)
• Kyle Schwarber has hit the Runs Under in 14 of his last 20 games at home (+10.35 Units / 50% ROI)

Cardinals Best Bets Today:

• The St. Louis Cardinals have hit the 1st Five Innings (F5) Moneyline in 29 of their last 50 away games (+19.15 Units / 36% ROI)
• The St. Louis Cardinals have covered the 1st Five Innings (F5) Run Line in 35 of their last 50 away games (+16.80 Units / 28% ROI)
• The St. Louis Cardinals have hit the Game Total Under in 30 of their last 50 games (+10.25 Units / 19% ROI)
• The St. Louis Cardinals have hit the Moneyline in 12 of their last 18 games (+8.65 Units / 42% ROI)
• The St. Louis Cardinals have hit the 1st Five Innings (F5) Team Total Under in 22 of their last 35 games (+7.00 Units / 16% ROI)

Phillies Best Bets Today:

• The Philadelphia Phillies have hit the Game Total Over in 14 of their last 23 games (+7.35 Units / 29% ROI)
• The Philadelphia Phillies have hit the Moneyline in their last 6 games (+6.00 Units / 61% ROI)
• The Philadelphia Phillies have covered the Run Line in 5 of their last 6 games (+5.15 Units / 82% ROI)
• The Philadelphia Phillies have covered the 1st Five Innings (F5) Run Line in 13 of their last 20 games (+4.55 Units / 19% ROI)
• The Philadelphia Phillies have hit the Team Total Over in 14 of their last 23 games (+4.45 Units / 17% ROI)

Cardinals Against the Spread (ATS) Record

Against the spread this season, the Cardinals are 70-56 against the Run Line (-0.45 Units / -0.25% ROI).

• 66-63 when betting on the Moneyline for +8.8 Units / 6.28% ROI
• 53-70 when betting on the total runs Over for -24.35 Units / -17.13% ROI
• 70-53 when betting on the total runs Under for +11.5 Units / 8.11% ROI

Phillies Against the Spread (ATS) Record

Against the spread this season, the Phillies are 51-76 against the Run Line (-30.8 Units / -20.53% ROI).

• 70-58 when betting on the Moneyline for -5.55 Units / -2.89% ROI
• 57-64 when betting on the total runs Over for -13.25 Units / -9.39% ROI
• 64-57 when betting on the total runs Under for +1.7 Units / 1.21% ROI

Phillies vs Cardinals Home Run Prop Bets Today

Phillies vs Cardinals Total Hits Prop Bets Today

Phillies vs Cardinals Strikeout Prop Bets Today

Cardinals Keys to the Game vs. the Phillies

The Cardinals are just 13-23 (.361) when tied entering the 8th inning since the 2025 season — 2nd lowest in MLB.

The Cardinals are just 12-112 (.097) when trailing entering the 7th inning since the 2025 season — tied for 3rd lowest in MLB.

The Cardinals were 69-1 (.986) when leading entering the 9th inning in the 2024 season — tied for 2nd best in MLB; League Avg: .949.

The Cardinals were just 7-11 (.389) when tied entering the 8th inning in the 2025 season — tied for 5th lowest in MLB; League Avg: .500.

Phillies Keys to the Game vs. the Cardinals

The Phillies are 15-0 (1.000) when they’ve had 5 or more XBH this season — best in MLB.

The Phillies are just 7-24 (.226) when their opponents score in the first inning this season — lowest in MLB.

The Phillies are 17-39 (.304) when allowing 5 or more runs this season — 3rd best in MLB.

The Phillies are 13-47 (.217) when trailing entering the 7th inning this season — 3rd best in MLB.

Cardinals Hitting Stats & Trends

Games involving the Cardinals went UNDER in 55% of their games (6.9% ROI) after a win this season — 5th highest in MLB.

The Cardinals are 37-26 (.587) against the run line (5.1% ROI) after a loss this season — 5th best in MLB.

Games involving the Cardinals went UNDER in 64% of their games (25.7% ROI) vs bottom 10 scoring offenses this season Today, they face the Phillies (16th in runs scored).

The Cardinals are 42-18 (.700) against the run line (13.2% ROI) when slight moneyline underdogs (+101 to +149) this season — best in MLB.

Phillies Hitting Stats & Trends

The Phillies are just 16-29 (.356) against the run line (-22.4% ROI) vs bottom 10 scoring offenses this season Today, they face the Cardinals (18th in runs scored).

The Phillies are just 51-77 (.398) against the run line (-17.9% ROI) this season — 2nd lowest in MLB.

The Phillies are just 23-46 (.333) against the run line (-32.9% ROI) after a win this season — 2nd lowest in MLB.

The Phillies are 15-0 (1.000) when they’ve had 5 or more XBH this season — best in MLB.

Cardinals Pitching Stats & Trends

Cardinals pitchers have a strikeout rate of 28% over the past seven days (8 games) — tied for 4th best in MLB; League Avg: 22%.

Batters facing the Cardinals pitchers put 41% of their swings in play in the 2025 season — tied for highest in MLB.

Cardinals pitchers have walked 13 of 125 batters (10%) when facing the leadoff batter in the inning over the last 14 days (14 games) — 5th highest in MLB; League Avg: 8%.

Opponents had a groundball rate of 47% against Cardinals pitchers in the 2025 season — 2nd highest in MLB.

Phillies Pitching Stats & Trends

Phillies pitchers have a strikeout rate of 49% with two-strikes this month (18 games) — best in MLB; League Avg: 42%.

Phillies pitchers have a strikeout rate of 27% over the last 14 days (12 games) — tied for 2nd best in MLB; League Avg: 22%.

Phillies pitchers have a strikeout rate of 28% this month (18 games) — best in MLB; League Avg: 22%.

Phillies pitchers have a strikeout rate of 47% with two-strikes over the last 14 days (12 games) — 3rd best in MLB; League Avg: 42%.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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