• The Phillies are -155 favorites vs the Cardinals
• Cardinals vs Phillies Over / Under today: 9 Runs
• Cardinals / Phillies TV Channel: CATV | NSPA

The St. Louis Cardinals (+125) visit Citizens Bank Park to take on the Philadelphia Phillies (-155) on August 22, 2026. First pitch is scheduled for 6:05 pm in Philadelphia, PA.

This season, the Cardinals are 66-64 against the spread (ATS), while the Phillies are 51-77 ATS.

Cardinals vs Phillies Starting Pitchers Today:

• Cardinals starting pitcher: Quinn Mathews 0-1, 3.00 ERA
• Phillies starting pitcher: Andrew Painter 2-8, 6.46 ERA

Cardinals vs. Phillies Odds, Run Line, Over/Under & Moneyline

Cardinals vs Phillies Prediction for Today’s Game

Based on recent trends the model predicts the Phillies will win Saturday‘s MLB game with 55.0% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Cardinals vs Phillies and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Cardinals players for Saturday‘s game, looking at profitable historical betting trends:

Best Cardinals Player Prop Bets Today:

• Jordan Walker has hit the Home Runs Over in 4 of his last 7 games (+14.00 Units / 200% ROI)
• Ivan Herrera has hit the Total Bases Under in 19 of his last 25 away games (+10.35 Units / 25% ROI)
• Alec Burleson has hit the Hits Over in 17 of his last 25 away games (+10.25 Units / 24% ROI)
• Blaze Jordan has hit the Runs Under in 17 of his last 20 games (+9.80 Units / 21% ROI)
• Jordan Walker has hit the Hits Runs and RBIs Over in 18 of his last 25 away games (+9.60 Units / 31% ROI)

And here are some favorite MLB player prop bets for Phillies players for Saturday‘s game, looking at profitable historical betting trends:

Best Phillies Player Prop Best Bets Today:

• Bryce Harper has hit the Walks Over in 17 of his last 20 games (+16.05 Units / 78% ROI)
• Luis Arraez has hit the Hits Over in 15 of his last 25 games at home (+14.30 Units / 57% ROI)
• Luis Arraez has hit the Hits Runs and RBIs Over in 20 of his last 25 games at home (+14.15 Units / 40% ROI)
• Luis Arraez has hit the Home Runs Over in 2 of his last 9 games at home (+14.00 Units / 156% ROI)
• Kyle Schwarber has hit the Runs Under in 17 of his last 25 games at home (+11.55 Units / 45% ROI)

Cardinals Best Bets Today:

• The St. Louis Cardinals have covered the 1st Five Innings (F5) Run Line in 35 of their last 50 away games (+16.80 Units / 28% ROI)
• The St. Louis Cardinals have hit the 1st Five Innings (F5) Moneyline in 28 of their last 50 away games (+16.65 Units / 31% ROI)
• The St. Louis Cardinals have hit the Game Total Under in 29 of their last 50 games (+8.15 Units / 15% ROI)
• The St. Louis Cardinals have hit the Moneyline in 12 of their last 19 games (+7.65 Units / 35% ROI)
• The St. Louis Cardinals have hit the Team Total Over in 21 of their last 35 away games (+6.00 Units / 15% ROI)

Phillies Best Bets Today:

• The Philadelphia Phillies have hit the Game Total Over in 15 of their last 24 games (+8.35 Units / 32% ROI)
• The Philadelphia Phillies have hit the Moneyline in their last 7 games (+7.00 Units / 56% ROI)
• The Philadelphia Phillies have hit the Team Total Over in 15 of their last 24 games (+5.45 Units / 20% ROI)
• The Philadelphia Phillies have covered the 1st Five Innings (F5) Run Line in 21 of their last 35 games (+4.65 Units / 11% ROI)
• The Philadelphia Phillies have covered the Run Line in 5 of their last 7 games (+3.90 Units / 52% ROI)

Cardinals Against the Spread (ATS) Record

Against the spread this season, the Cardinals are 71-56 against the Run Line (+0.6 Units / 0.33% ROI).

• 66-64 when betting on the Moneyline for +7.8 Units / 5.53% ROI
• 54-70 when betting on the total runs Over for -23.35 Units / -16.3% ROI
• 70-54 when betting on the total runs Under for +10.4 Units / 7.28% ROI

Phillies Against the Spread (ATS) Record

Against the spread this season, the Phillies are 51-77 against the Run Line (-32.05 Units / -21.19% ROI).

• 71-58 when betting on the Moneyline for -4.55 Units / -2.34% ROI
• 58-64 when betting on the total runs Over for -12.25 Units / -8.61% ROI
• 64-58 when betting on the total runs Under for +0.6 Units / 0.42% ROI

Phillies vs Cardinals Home Run Prop Bets Today

Phillies vs Cardinals Total Hits Prop Bets Today

Phillies vs Cardinals Strikeout Prop Bets Today

Cardinals Keys to the Game vs. the Phillies

The Cardinals are just 12-113 (.096) when trailing entering the 7th inning since the 2025 season — tied for 3rd lowest in MLB.

The Cardinals are just 13-23 (.361) when tied entering the 8th inning since the 2025 season — 2nd lowest in MLB.

The Cardinals were just 7-11 (.389) when tied entering the 8th inning in the 2025 season — tied for 5th lowest in MLB; League Avg: .500.

The Cardinals were 69-1 (.986) when leading entering the 9th inning in the 2024 season — tied for 2nd best in MLB; League Avg: .949.

Phillies Keys to the Game vs. the Cardinals

The Phillies are 13-47 (.217) when trailing entering the 7th inning this season — 3rd best in MLB.

The Phillies are 16-0 (1.000) when they’ve had 5 or more XBH this season — best in MLB.

The Phillies are 5-52 (.088) when trailing entering the 9th inning this season — 5th best in MLB.

The Phillies are 18-39 (.316) when allowing 5 or more runs this season — 2nd best in MLB.

Cardinals Hitting Stats & Trends

Cardinals hitters have struck out in just 19% of their PA’s against LHP this season — tied for 2nd best in MLB.

Cardinals hitters are slugging just .380 against RHP this season — tied for 3rd lowest in MLB.

Cardinals hitters have an OPS of .730 (2,525 PA’s) on the road this season — 5th best in MLB.

Cardinals hitters have an OPS of just .669 (2,411 PA’s) at home this season — 2nd lowest in MLB.

Phillies Hitting Stats & Trends

Phillies hitters have an OPS of 1.240 (901 PA’s) with the pitcher behind in the count this season — best in MLB.

Phillies hitters are slugging .730 with the pitcher behind in the count this season — best in MLB.

Phillies hitters have 119 extra-base hits out of 237 total hits (50%) with the pitcher behind in the count this season — best in MLB.

Phillies hitters have an OPS of just .473 (2,598 PA’s) with two-strikes this season — lowest in MLB.

Cardinals Pitching Stats & Trends

The Cardinals pitchers have allowed their opponents to score first in just 31% of their games on the road this season — lowest in MLB.

Opponents have a groundball rate of 45% against Cardinals pitchers this season — tied for 3rd highest in MLB.

Cardinals pitchers have induced opposing hitters to ground into 115 double plays in 971 opportunities (12%) this season — best in MLB.

Opponents have a miss rate of just 23% against Cardinals pitchers this season — 4th lowest in MLB.

Phillies Pitching Stats & Trends

Phillies pitchers have a strikeout rate of 48% with two-strikes this season — best in MLB.

Opponents have a miss rate of 28% against Phillies pitchers this season — tied for best in MLB.

Phillies pitchers have a strikeout rate of 26% this season — 2nd best in MLB.

The Phillies pitchers have allowed an average Exit Velocity of just 87.7 MPH this season (3,053 balls in play) — best in MLB

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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