• The Pirates are -135 favorites vs the Cardinals
• Cardinals vs Pirates Over / Under today: 8 Runs
• Cardinals / Pirates TV Channel: CATV | SNPT

The St. Louis Cardinals (+110) visit PNC Park to take on the Pittsburgh Pirates (-135) on April 27, 2026. First pitch is scheduled for 6:40 pm in Pittsburgh, PA.

This season, the Cardinals are 14-13 against the spread (ATS), while the Pirates are 17-11 ATS.

Cardinals vs Pirates Starting Pitchers Today:

• Cardinals starting pitcher: Dustin May 3-2, 6.09 ERA
• Pirates starting pitcher: Mason Montgomery 1-0, 3.97 ERA

Cardinals vs. Pirates Odds, Run Line, Over/Under & Moneyline

Cardinals vs Pirates Prediction for Today’s Game

Based on recent trends the model predicts the Pirates will win Monday‘s MLB game with 53.5% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Cardinals vs Pirates and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Cardinals players for Monday‘s game, looking at profitable historical betting trends:

Best Cardinals Player Prop Bets Today:

• Nathan Church has hit the Home Runs Over in 3 of his last 5 games (+25.00 Units / 500% ROI)
• Jordan Walker has hit the Runs Over in 16 of his last 25 games (+14.15 Units / 56% ROI)
• Nolan Gorman has hit the Singles Over in 13 of his last 25 games (+9.55 Units / 38% ROI)
• Yohel Pozo has hit the Hits Under in 12 of his last 20 games (+9.10 Units / 43% ROI)
• Masyn Winn has hit the Hits Runs and RBIs Over in 9 of his last 10 games (+9.05 Units / 90% ROI)

And here are some favorite MLB player prop bets for Pirates players for Monday‘s game, looking at profitable historical betting trends:

Best Pirates Player Prop Best Bets Today:

• Bryan Reynolds has hit the Walks Over in 15 of his last 20 games at home (+18.40 Units / 92% ROI)
• Bryan Reynolds has hit the Runs Over in 17 of his last 25 games at home (+13.30 Units / 52% ROI)
• Oneil Cruz has hit the RBIs Over in 13 of his last 25 games at home (+10.75 Units / 43% ROI)
• Ryan O’Hearn has hit the Hits Over in 19 of his last 25 games (+9.55 Units / 21% ROI)
• Spencer Horwitz has hit the Singles Over in 15 of his last 25 games (+8.05 Units / 32% ROI)

Cardinals Best Bets Today:

• The St. Louis Cardinals have hit the Team Total Over in 9 of their last 11 away games (+6.75 Units / 52% ROI)
• The St. Louis Cardinals have hit the 1st Five Innings (F5) Team Total Over in 22 of their last 35 away games (+5.50 Units / 13% ROI)
• The St. Louis Cardinals have hit the Game Total Over in 20 of their last 35 away games (+5.45 Units / 14% ROI)
• The St. Louis Cardinals have hit the Moneyline in 7 of their last 10 away games (+4.55 Units / 44% ROI)
• The St. Louis Cardinals have covered the 1st Five Innings (F5) Run Line in 7 of their last 9 games (+4.50 Units / 39% ROI)

Pirates Best Bets Today:

• The Pittsburgh Pirates have covered the Run Line in 29 of their last 45 games at home (+12.25 Units / 21% ROI)
• The Pittsburgh Pirates have hit the 1st Five Innings (F5) Team Total Over in 29 of their last 45 games at home (+10.45 Units / 19% ROI)
• The Pittsburgh Pirates have hit the 1st Five Innings (F5) Moneyline in 26 of their last 50 games at home (+9.10 Units / 13% ROI)
• The Pittsburgh Pirates have covered the 1st Five Innings (F5) Run Line in 23 of their last 35 games (+8.95 Units / 21% ROI)
• The Pittsburgh Pirates have hit the Moneyline in 21 of their last 35 games (+7.40 Units / 18% ROI)

Cardinals Against the Spread (ATS) Record

Against the spread this season, the Cardinals are 15-11 against the Run Line (-0.85 Units / -2.14% ROI).

• 14-13 when betting on the Moneyline for +2.6 Units / 9.42% ROI
• 14-12 when betting on the total runs Over for +0.75 Units / 2.53% ROI
• 12-14 when betting on the total runs Under for -3.65 Units / -12.21% ROI

Pirates Against the Spread (ATS) Record

Against the spread this season, the Pirates are 17-11 against the Run Line (+4.9 Units / 12.96% ROI).

• 16-12 when betting on the Moneyline for +3 Units / 8.76% ROI
• 15-13 when betting on the total runs Over for +0.55 Units / 1.78% ROI
• 13-15 when betting on the total runs Under for -3.55 Units / -11.56% ROI

Pirates vs Cardinals Home Run Prop Bets Today

Pirates vs Cardinals Total Hits Prop Bets Today

Pirates vs Cardinals Strikeout Prop Bets Today

Cardinals Keys to the Game vs. the Pirates

The Cardinals are just 8-78 (.093) when trailing entering the 7th inning since the 2025 season — 5th lowest in MLB; League Avg: .127.

The Cardinals are 8-4 (.667) vs top 10 scoring offenses this season Today, they face the Pirates (seventh in runs scored).

The Cardinals were 18-9 (.667) when tied entering the 7th inning in the 2024 season — tied for 3rd best in MLB; League Avg: .498.

The Cardinals were 69-1 (.986) when leading entering the 9th inning in the 2024 season — tied for 2nd best in MLB; League Avg: .949.

Pirates Keys to the Game vs. the Cardinals

The Pirates are just 1-10 (.091) when allowing 5 or more runs this season — 2nd lowest in MLB; League Avg: .227.

The Pirates are 10-1 (.909) after a loss this season — best in MLB; League Avg: .473.

The Pirates are just 7-49 (.125) when allowing 10 or more hits since the 2025 season — lowest in MLB; League Avg: .252.

The Pirates are just 1-89 (.011) when trailing entering the 9th inning since the 2025 season — 2nd lowest in MLB; League Avg: .044.

Cardinals Hitting Stats & Trends

Cardinals hitters are slugging just .484 with the pitcher behind in the count since the 2025 season — lowest in MLB.

Cardinals hitters have an OPS of just .693 (5,157 PA’s) against RHP since the 2025 season — 5th lowest in MLB.

Cardinals hitters have 30 extra-base hits out of 121 total hits (just 25%) against starting pitchers this season — lowest in MLB.

The Cardinals are batting just .280 on the first pitch of at-bats this season — tied for 3rd lowest in MLB.

Pirates Hitting Stats & Trends

Pirates hitters have an OPS of just .622 (3,619 PA’s) on the road since the 2025 season — 2nd lowest in MLB.

Pirates hitters have struck out in 39% of their PA’s against LHP over the past seven days (6 games) — highest in MLB.

Pirates hitters have an OPS of just .597 (2,166 PA’s) in innings 7-9 since the 2025 season — lowest in MLB.

Pirates hitters have 16 extra-base hits out of 74 total hits (just 22%) against LHP this season — lowest in MLB.

Cardinals Pitching Stats & Trends

Opponents have a miss rate of just 20% against Cardinals pitchers this season — lowest in MLB.

Cardinals pitchers have a strikeout rate of just 34% with two-strikes this season — lowest in MLB.

Cardinals pitchers have a strikeout rate of just 17% this season — lowest in MLB.

Cardinals pitchers have a strikeout rate of just 16% versus hitters not batting 3-4-5 in the order this season — lowest in MLB.

Pirates Pitching Stats & Trends

Pirates pitchers have walked 13% of batters when facing the leadoff batter in the inning this season — 2nd highest in MLB.

Pirates pitchers have a strikeout rate of 45% with two-strikes this season — tied for 3rd best in MLB.

Pirates pitchers have a strikeout rate of 24% this season — 5th best in MLB.

Pirates pitchers have a strikeout rate of 23% over the last 14 days — 5th best in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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