• The Pirates are -150 favorites vs the Cardinals
• Cardinals vs Pirates Over / Under today: 8.5 Runs
• Cardinals / Pirates TV Channel: CATV | SNPT

The St. Louis Cardinals (+125) visit PNC Park to take on the Pittsburgh Pirates (-150) on April 28, 2026. First pitch is scheduled for 6:40 pm in Pittsburgh, PA.

This season, the Cardinals are 15-13 against the spread (ATS), while the Pirates are 17-12 ATS.

Cardinals vs Pirates Starting Pitchers Today:

• Cardinals starting pitcher: Kyle Leahy 2-3, 5.71 ERA
• Pirates starting pitcher: Bubba Chandler 1-2, 4.88 ERA

Cardinals vs. Pirates Odds, Run Line, Over/Under & Moneyline

Cardinals vs Pirates Prediction for Today’s Game

Based on recent trends the model predicts the Pirates will win Tuesday‘s MLB game with 56.5% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Cardinals vs Pirates and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Cardinals players for Tuesday‘s game, looking at profitable historical betting trends:

Best Cardinals Player Prop Bets Today:

• Nathan Church has hit the Home Runs Over in 3 of his last 6 games (+24.00 Units / 400% ROI)
• Jordan Walker has hit the Runs Over in 15 of his last 25 games (+11.45 Units / 46% ROI)
• Marcell Ozuna has hit the Walks Under in 13 of his last 15 games (+9.55 Units / 33% ROI)
• Jordan Walker has hit the Hits Over in 16 of his last 20 games (+8.70 Units / 22% ROI)
• Jordan Walker has hit the RBIs Under in his last 8 games (+8.00 Units / 47% ROI)

And here are some favorite MLB player prop bets for Pirates players for Tuesday‘s game, looking at profitable historical betting trends:

Best Pirates Player Prop Best Bets Today:

• Nick Gonzales has hit the Hits Over in 15 of his last 20 games (+8.70 Units / 24% ROI)
• Nick Gonzales has hit the Hits Runs and RBIs Over in 16 of his last 25 games (+7.75 Units / 28% ROI)
• Nick Gonzales has hit the Total Bases Over in 15 of his last 25 games (+7.15 Units / 24% ROI)
• Nick Gonzales has hit the Singles Over in 14 of his last 20 games (+7.05 Units / 29% ROI)
• Konnor Griffin has hit the Home Runs Over in 1 of his last 4 games (+6.00 Units / 150% ROI)

Cardinals Best Bets Today:

• The St. Louis Cardinals have hit the Team Total Over in 10 of their last 12 away games (+7.75 Units / 54% ROI)
• The St. Louis Cardinals have hit the Moneyline in 8 of their last 11 away games (+5.55 Units / 49% ROI)
• The St. Louis Cardinals have hit the Game Total Under in 6 of their last 7 games (+4.90 Units / 65% ROI)
• The St. Louis Cardinals have covered the Run Line in 9 of their last 12 games (+4.45 Units / 23% ROI)
• The St. Louis Cardinals have hit the 1st Five Innings (F5) Team Total Under in 9 of their last 15 games (+3.05 Units / 18% ROI)

Pirates Best Bets Today:

• The Pittsburgh Pirates have covered the Run Line in 29 of their last 45 games at home (+12.25 Units / 21% ROI)
• The Pittsburgh Pirates have hit the 1st Five Innings (F5) Team Total Over in 29 of their last 45 games at home (+10.55 Units / 19% ROI)
• The Pittsburgh Pirates have hit the 1st Five Innings (F5) Moneyline in 24 of their last 45 games at home (+9.85 Units / 16% ROI)
• The Pittsburgh Pirates have covered the 1st Five Innings (F5) Run Line in 29 of their last 45 games at home (+9.75 Units / 18% ROI)
• The Pittsburgh Pirates have hit the Game Total Under in 29 of their last 50 games (+7.05 Units / 13% ROI)

Cardinals Against the Spread (ATS) Record

Against the spread this season, the Cardinals are 16-11 against the Run Line (+0.15 Units / 0.36% ROI).

• 15-13 when betting on the Moneyline for +3.6 Units / 12.59% ROI
• 14-13 when betting on the total runs Over for -0.35 Units / -1.14% ROI
• 13-14 when betting on the total runs Under for -2.65 Units / -8.55% ROI

Pirates Against the Spread (ATS) Record

Against the spread this season, the Pirates are 17-12 against the Run Line (+3.9 Units / 10.05% ROI).

• 16-13 when betting on the Moneyline for +1.8 Units / 5.08% ROI
• 15-14 when betting on the total runs Over for -0.55 Units / -1.72% ROI
• 14-15 when betting on the total runs Under for -2.55 Units / -8.02% ROI

Pirates vs Cardinals Home Run Prop Bets Today

Pirates vs Cardinals Total Hits Prop Bets Today

Pirates vs Cardinals Strikeout Prop Bets Today

Cardinals Keys to the Game vs. the Pirates

The Cardinals are 2-11 (.154) when trailing entering the 9th inning this season — 4th best in MLB; League Avg: .054.

The Cardinals are 151-5 (.968) when leading entering the 9th inning since the 2024 season — 5th best in MLB; League Avg: .952.

The Cardinals are 138-9 (.939) when leading entering the 8th inning since the 2024 season — 3rd best in MLB; League Avg: .903.

The Cardinals were 69-1 (.986) when leading entering the 9th inning in the 2024 season — tied for 2nd best in MLB; League Avg: .949.

Pirates Keys to the Game vs. the Cardinals

The Pirates are just 7-60 (.104) when allowing 5 or more runs since the 2025 season — lowest in MLB; League Avg: .206.

The Pirates are just 0-6 (.000) when allowing 10 or more hits this season — lowest in MLB; League Avg: .230.

The Pirates are 10-2 (.833) after a loss this season — best in MLB; League Avg: .472.

The Pirates are just 0-9 (.000) when trailing entering the 9th inning this season — tied for lowest in MLB; League Avg: .054.

Cardinals Hitting Stats & Trends

The Cardinals are batting just .216 with two outs since the 2025 season — tied for lowest in MLB.

Cardinals hitters have an OPS of just .941 (1,357 PA’s) with the pitcher behind in the count since the 2025 season — lowest in MLB.

Cardinals hitters are slugging just .482 with the pitcher behind in the count since the 2025 season — lowest in MLB.

Cardinals hitters have 30 extra-base hits out of 121 total hits (just 25%) against starting pitchers this season — lowest in MLB.

Pirates Hitting Stats & Trends

Pirates hitters are slugging just .158 on pitches out of the zone since the 2025 season — lowest in MLB.

The Pirates are batting just .223 against LHP since the 2025 season — 2nd lowest in MLB.

The Pirates are batting just .215 on the road since the 2025 season — 2nd lowest in MLB.

Pirates hitters have an OPS of just .622 (3,619 PA’s) on the road since the 2025 season — 2nd lowest in MLB.

Cardinals Pitching Stats & Trends

Opponents have a miss rate of just 20% against Cardinals pitchers this season — lowest in MLB.

Cardinals pitchers have a strikeout rate of just 34% with two-strikes this season — lowest in MLB.

Cardinals pitchers have a strikeout rate of just 17% this season — lowest in MLB.

Cardinals pitchers have a strikeout rate of just 19% since the 2025 season — 2nd lowest in MLB.

Pirates Pitching Stats & Trends

Pirates pitchers have walked 13% of batters when facing the leadoff batter in the inning this season — 3rd highest in MLB.

Pirates pitchers have a strikeout rate of 24% this season — 5th best in MLB.

Pirates pitchers have a strikeout rate of 23% over the last 14 days — 5th best in MLB.

Pirates pitchers have a strikeout rate of 45% with two-strikes this season — 4th best in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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