• The Pirates are -150 favorites vs the Cardinals
• Cardinals vs Pirates Over / Under today: 8.5 Runs
• Cardinals / Pirates TV Channel: CATV | SNP+

The St. Louis Cardinals (+125) visit PNC Park to take on the Pittsburgh Pirates (-150) on April 29, 2026. First pitch is scheduled for 6:40 pm in Pittsburgh, PA.

This season, the Cardinals are 16-13 against the spread (ATS), while the Pirates are 17-13 ATS.

Cardinals vs Pirates Starting Pitchers Today:

• Cardinals starting pitcher: Andre Pallante 2-2, 4.21 ERA
• Pirates starting pitcher: Bubba Chandler 1-2, 4.88 ERA

Cardinals vs. Pirates Odds, Run Line, Over/Under & Moneyline

Cardinals vs Pirates Prediction for Today’s Game

Based on recent trends the model predicts the Pirates will win Wednesday‘s MLB game with 59.1% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Cardinals vs Pirates and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Cardinals players for Wednesday‘s game, looking at profitable historical betting trends:

Best Cardinals Player Prop Bets Today:

• Nathan Church has hit the Home Runs Over in 3 of his last 7 games (+23.00 Units / 329% ROI)
• Jordan Walker has hit the Runs Over in 15 of his last 25 games (+11.10 Units / 44% ROI)
• Andre Pallante has hit the Pitching Outs Under in his last 9 away games (+9.00 Units / 85% ROI)
• Andre Pallante has hit the Walks Allowed Over in 9 of his last 10 away games (+8.75 Units / 67% ROI)
• Jordan Walker has hit the Hits Over in 16 of his last 20 games (+8.70 Units / 22% ROI)

And here are some favorite MLB player prop bets for Pirates players for Wednesday‘s game, looking at profitable historical betting trends:

Best Pirates Player Prop Best Bets Today:

• Bryan Reynolds has hit the Walks Over in 18 of his last 25 games at home (+20.70 Units / 83% ROI)
• Konnor Griffin has hit the Home Runs Over in 2 of his last 5 games (+14.00 Units / 280% ROI)
• Bryan Reynolds has hit the Runs Over in 17 of his last 25 games at home (+13.50 Units / 53% ROI)
• Oneil Cruz has hit the RBIs Over in 13 of his last 25 games at home (+10.90 Units / 44% ROI)
• Ryan O’Hearn has hit the Hits Over in 19 of his last 25 games (+9.55 Units / 21% ROI)

Cardinals Best Bets Today:

• The St. Louis Cardinals have hit the Team Total Over in 11 of their last 13 away games (+8.75 Units / 56% ROI)
• The St. Louis Cardinals have hit the Moneyline in 9 of their last 12 away games (+6.95 Units / 56% ROI)
• The St. Louis Cardinals have hit the Game Total Over in 28 of their last 50 away games (+6.90 Units / 13% ROI)
• The St. Louis Cardinals have covered the Run Line in 10 of their last 13 games (+5.45 Units / 26% ROI)
• The St. Louis Cardinals have hit the 1st Five Innings (F5) Team Total Over in 22 of their last 35 away games (+5.30 Units / 12% ROI)

Pirates Best Bets Today:

• The Pittsburgh Pirates have covered the Run Line in 28 of their last 45 games at home (+9.60 Units / 16% ROI)
• The Pittsburgh Pirates have covered the 1st Five Innings (F5) Run Line in 26 of their last 40 games (+9.45 Units / 20% ROI)
• The Pittsburgh Pirates have hit the 1st Five Innings (F5) Team Total Over in 28 of their last 45 games at home (+8.45 Units / 15% ROI)
• The Pittsburgh Pirates have hit the 1st Five Innings (F5) Moneyline in 26 of their last 50 games at home (+7.15 Units / 10% ROI)
• The Pittsburgh Pirates have hit the Game Total Under in 28 of their last 50 games (+4.95 Units / 9% ROI)

Cardinals Against the Spread (ATS) Record

Against the spread this season, the Cardinals are 17-11 against the Run Line (+1.15 Units / 2.66% ROI).

• 16-13 when betting on the Moneyline for +5 Units / 16.89% ROI
• 15-13 when betting on the total runs Over for +0.65 Units / 2.04% ROI
• 13-15 when betting on the total runs Under for -3.75 Units / -11.68% ROI

Pirates Against the Spread (ATS) Record

Against the spread this season, the Pirates are 17-13 against the Run Line (+2.9 Units / 7.29% ROI).

• 16-14 when betting on the Moneyline for +0.2 Units / 0.54% ROI
• 16-14 when betting on the total runs Over for +0.45 Units / 1.36% ROI
• 14-16 when betting on the total runs Under for -3.65 Units / -11.09% ROI

Pirates vs Cardinals Home Run Prop Bets Today

Pirates vs Cardinals Total Hits Prop Bets Today

Pirates vs Cardinals Strikeout Prop Bets Today

Cardinals Keys to the Game vs. the Pirates

The Cardinals are 9-5 (.643) on the road this season — tied for 4th best in MLB; League Avg: .464.

The Cardinals are 2-11 (.154) when trailing entering the 9th inning this season — 4th best in MLB; League Avg: .053.

The Cardinals are 75-5 (.938) when leading entering the 8th inning since the 2025 season — 5th best in MLB; League Avg: .907.

The Cardinals were 18-9 (.667) when tied entering the 7th inning in the 2024 season — tied for 3rd best in MLB; League Avg: .498.

Pirates Keys to the Game vs. the Cardinals

The Pirates are just 1-90 (.011) when trailing entering the 9th inning since the 2025 season — 2nd lowest in MLB; League Avg: .045.

The Pirates are just 8-40 (.167) when allowing 2 or more home runs since the 2025 season — lowest in MLB; League Avg: .303.

The Pirates are just 0-7 (.000) when allowing 10 or more hits this season — lowest in MLB; League Avg: .234.

The Pirates are just 14-94 (.130) when allowing 10 or more hits since the 2024 season — 2nd lowest in MLB; League Avg: .252.

Cardinals Hitting Stats & Trends

Cardinals hitters have struck out in just 19% of their PA’s against LHP this season — 5th best in MLB.

Cardinals hitters have an OPS of just .945 (1,366 PA’s) with the pitcher behind in the count since the 2025 season — lowest in MLB.

Cardinals hitters are slugging just .381 since the 2025 season — tied for 4th lowest in MLB.

The Cardinals are batting just .217 with two outs since the 2025 season — 2nd lowest in MLB.

Pirates Hitting Stats & Trends

Pirates hitters have an OPS of just .622 (3,619 PA’s) on the road since the 2025 season — 2nd lowest in MLB.

Pirates hitters are slugging just .355 since the 2025 season — lowest in MLB.

The Pirates are batting just .215 on the road since the 2025 season — 2nd lowest in MLB.

Pirates hitters are slugging just .359 against RHP since the 2025 season — lowest in MLB.

Cardinals Pitching Stats & Trends

Cardinals pitchers have a strikeout rate of just 17% this season — lowest in MLB.

Cardinals pitchers have a strikeout rate of just 35% with two-strikes this season — lowest in MLB.

Opponents have a miss rate of just 20% against Cardinals pitchers this month (24 games) — lowest in MLB.

Opponents have a miss rate of just 22% against Cardinals pitchers since the 2025 season — lowest in MLB.

Pirates Pitching Stats & Trends

Pirates pitchers have walked 13% of batters when facing the leadoff batter in the inning this season — 2nd highest in MLB.

Pirates pitchers have a strikeout rate of 45% with two-strikes this season — 4th best in MLB.

Pirates pitchers have an ERA of 3.55 (134.1 IP) on the road this season — 5th best in MLB.

Opponents are hitting just .221 against Pirates pitchers this season — 3rd best in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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