• The Pirates are -155 favorites vs the Cardinals
• Cardinals vs Pirates Over / Under today: 7 Runs
• Cardinals / Pirates TV Channel: CATV | SNPT

The St. Louis Cardinals (+125) visit PNC Park to take on the Pittsburgh Pirates (-155) on September 22, 2026. First pitch is scheduled for 6:40 pm in Pittsburgh, PA.

This season, the Cardinals are 76-80 against the spread (ATS), while the Pirates are 76-76 ATS.

Cardinals vs Pirates Starting Pitchers Today:

• Cardinals starting pitcher: Andre Pallante 12-7, 3.71 ERA
• Pirates starting pitcher: Jared Jones 4-6, 4.17 ERA

Cardinals vs. Pirates Odds, Run Line, Over/Under & Moneyline

Cardinals vs Pirates Prediction for Today’s Game

Based on recent trends the model predicts the Pirates will win Tuesday‘s MLB game with 55.5% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Cardinals vs Pirates and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Cardinals players for Tuesday‘s game, looking at profitable historical betting trends:

Best Cardinals Player Prop Bets Today:

• Nathan Church has hit the Singles Over in 17 of his last 20 away games (+15.90 Units / 75% ROI)
• Nathan Church has hit the Hits Over in 18 of his last 20 away games (+14.70 Units / 44% ROI)
• Nathan Church has hit the Hits Runs and RBIs Over in 16 of his last 20 away games (+13.35 Units / 55% ROI)
• Leonardo Bernal has hit the Home Runs Over in 3 of his last 10 games (+13.00 Units / 130% ROI)
• Masyn Winn has hit the Total Bases Under in 17 of his last 25 away games (+11.75 Units / 36% ROI)

And here are some favorite MLB player prop bets for Pirates players for Tuesday‘s game, looking at profitable historical betting trends:

Best Pirates Player Prop Best Bets Today:

• Brandon Lowe has hit the Home Runs Over in 4 of his last 6 games (+15.70 Units / 262% ROI)
• Brandon Lowe has hit the Hits Over in 21 of his last 25 games at home (+13.40 Units / 27% ROI)
• Konnor Griffin has hit the Total Bases Over in 17 of his last 25 games at home (+12.30 Units / 42% ROI)
• Konnor Griffin has hit the Runs Over in 15 of his last 25 games at home (+10.60 Units / 42% ROI)
• Oneil Cruz has hit the Singles Over in 13 of his last 20 games (+9.60 Units / 48% ROI)

Cardinals Best Bets Today:

• The St. Louis Cardinals have hit the Game Total Over in 28 of their last 40 games (+16.85 Units / 38% ROI)
• The St. Louis Cardinals have hit the 1st Five Innings (F5) Moneyline in 22 of their last 35 away games (+16.20 Units / 43% ROI)
• The St. Louis Cardinals have covered the 1st Five Innings (F5) Run Line in 25 of their last 35 away games (+13.05 Units / 32% ROI)
• The St. Louis Cardinals have hit the Team Total Over in 27 of their last 40 games (+11.70 Units / 24% ROI)
• The St. Louis Cardinals have hit the 1st Five Innings (F5) Team Total Under in their last 7 games (+7.05 Units / 75% ROI)

Pirates Best Bets Today:

• The Pittsburgh Pirates have hit the Game Total Over in 30 of their last 50 games at home (+10.45 Units / 19% ROI)
• The Pittsburgh Pirates have hit the 1st Five Innings (F5) Team Total Under in 17 of their last 25 games (+9.60 Units / 33% ROI)
• The Pittsburgh Pirates have covered the Run Line in 10 of their last 12 games (+8.55 Units / 48% ROI)
• The Pittsburgh Pirates have hit the Moneyline in 14 of their last 20 games (+7.70 Units / 30% ROI)
• The Pittsburgh Pirates have covered the 1st Five Innings (F5) Run Line in 13 of their last 20 games (+5.05 Units / 20% ROI)

Cardinals Against the Spread (ATS) Record

Against the spread this season, the Cardinals are 84-69 against the Run Line (-0.6 Units / -0.28% ROI).

• 76-80 when betting on the Moneyline for +1.1 Units / 0.64% ROI
• 73-76 when betting on the total runs Over for -11.25 Units / -6.53% ROI
• 76-73 when betting on the total runs Under for -4.25 Units / -2.49% ROI

Pirates Against the Spread (ATS) Record

Against the spread this season, the Pirates are 76-76 against the Run Line (-6 Units / -3.01% ROI).

• 79-77 when betting on the Moneyline for -8.4 Units / -4.36% ROI
• 80-69 when betting on the total runs Over for +4.2 Units / 2.44% ROI
• 69-80 when betting on the total runs Under for -18.65 Units / -10.89% ROI

Cardinals Keys to the Game vs. the Pirates

The Cardinals are just 28-18 (.609) when they’ve had 10 or more hits this season — 2nd lowest in MLB.

The Cardinals are just 6-14 (.300) when tied entering the 8th inning this season — tied for 3rd lowest in MLB.

The Cardinals are 9-58 (.134) when trailing entering the 8th inning this season — 5th best in MLB.

The Cardinals are 17-127 (.118) when trailing entering the 8th inning since the 2025 season — tied for 5th best in MLB.

Pirates Keys to the Game vs. the Cardinals

The Pirates are just 7-37 (.159) when allowing 10 or more hits this season — 4th lowest in MLB.

The Pirates are just 24-99 (.195) when allowing 2 or more home runs since the 2024 season — lowest in MLB.

The Pirates are just 14-80 (.149) when allowing 10 or more hits since the 2025 season — lowest in MLB.

The Pirates were just 10-32 (.238) when their opponents score in the first inning in the 2024 season — 3rd lowest in MLB; League Avg: .359.

Cardinals Hitting Stats & Trends

Cardinals hitters have struck out in just 19% of their PA’s against LHP this season — 3rd best in MLB.

The Cardinals are batting .276 when facing the starting pitcher for the 3rd time in a game this season — tied for 2nd best in MLB.

Cardinals hitters are slugging just .377 against RHP this season — 2nd lowest in MLB.

The Cardinals have scored 5.25 runs per game (394/75) on the road this season — 3rd best in MLB.

Pirates Hitting Stats & Trends

Pirates hitters have an OBP of .349 (3,003 PA’s) at home this season — tied for 2nd best in MLB.

Pirates hitters have struck out in 25% of their PA’s against LHP this season — 2nd highest in MLB.

The Pirates are batting .274 when facing the starting pitcher for the 3rd time in a game this season — 5th best in MLB.

The Pirates are batting .270 at home this season — 2nd best in MLB.

Cardinals Pitching Stats & Trends

Opponents have a groundball rate of 45% against Cardinals pitchers this season — 4th highest in MLB.

Cardinals pitchers have allowed an exit velocity over 105 MPH 395 times this season — 2nd most in MLB.

Cardinals pitchers have a strikeout rate of just 20% with runners in scoring position this season — 5th lowest in MLB.

Cardinals pitchers have induced opposing hitters to ground into 132 double plays in 1,178 opportunities (11%) this season — tied for best in MLB.

Pirates Pitching Stats & Trends

The Pirates pitchers have allowed their opponents to score first in just 39% of their games on the road this season — tied for 2nd lowest in MLB.

Pirates pitchers have walked 10% of batters when facing the leadoff batter in the inning this season — 4th highest in MLB.

Pirates pitchers have an ERA of 4.41 (714.0 IP) at home this season — 4th highest in MLB.

The softest ball hit off of the Pirates pitchers this season was just 16.7 MPH — tied for 5th best in MLB

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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