• The Pirates are -140 favorites vs the Cardinals
• Cardinals vs Pirates Over / Under today: 7.5 Runs
• Cardinals / Pirates TV Channel: CATV | SNPT

The St. Louis Cardinals (+115) visit PNC Park to take on the Pittsburgh Pirates (-140) on September 23, 2026. First pitch is scheduled for 6:40 pm in Pittsburgh, PA.

This season, the Cardinals are 76-81 against the spread (ATS), while the Pirates are 77-76 ATS.

Cardinals vs Pirates Starting Pitchers Today:

• Cardinals starting pitcher: Matthew Liberatore 5-14, 5.38 ERA
• Pirates starting pitcher: Lake Bachar 1-4, 3.58 ERA

Cardinals vs. Pirates Odds, Run Line, Over/Under & Moneyline

Cardinals vs Pirates Prediction for Today’s Game

Based on recent trends the model predicts the Pirates will win Wednesday‘s MLB game with 51.0% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Cardinals vs Pirates and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Cardinals players for Wednesday‘s game, looking at profitable historical betting trends:

Best Cardinals Player Prop Bets Today:

• Alec Burleson has hit the Hits Under in 16 of his last 20 games (+15.70 Units / 47% ROI)
• Nathan Church has hit the Singles Over in 19 of his last 25 away games (+15.05 Units / 57% ROI)
• Nathan Church has hit the Hits Runs and RBIs Over in 19 of his last 25 away games (+14.55 Units / 48% ROI)
• Masyn Winn has hit the Total Bases Under in 15 of his last 20 away games (+12.55 Units / 49% ROI)
• JJ Wetherholt has hit the Walks Under in 14 of his last 15 games (+12.50 Units / 46% ROI)

And here are some favorite MLB player prop bets for Pirates players for Wednesday‘s game, looking at profitable historical betting trends:

Best Pirates Player Prop Best Bets Today:

• Brandon Lowe has hit the Home Runs Over in 4 of his last 7 games (+14.70 Units / 210% ROI)
• Brandon Lowe has hit the Hits Over in 21 of his last 25 games at home (+12.80 Units / 26% ROI)
• Konnor Griffin has hit the Total Bases Over in 17 of his last 25 games at home (+12.55 Units / 43% ROI)
• Nick Gonzales has hit the Runs Under in 20 of his last 25 games (+10.35 Units / 21% ROI)
• Oneil Cruz has hit the Singles Over in 10 of his last 15 games (+8.00 Units / 53% ROI)

Cardinals Best Bets Today:

• The St. Louis Cardinals have hit the 1st Five Innings (F5) Moneyline in 28 of their last 50 away games (+16.30 Units / 30% ROI)
• The St. Louis Cardinals have hit the Game Total Over in 25 of their last 35 games (+14.95 Units / 39% ROI)
• The St. Louis Cardinals have covered the 1st Five Innings (F5) Run Line in 34 of their last 50 away games (+14.30 Units / 24% ROI)
• The St. Louis Cardinals have hit the Team Total Over in 26 of their last 40 games (+9.70 Units / 20% ROI)
• The St. Louis Cardinals have hit the 1st Five Innings (F5) Team Total Under in their last 8 games (+8.05 Units / 76% ROI)

Pirates Best Bets Today:

• The Pittsburgh Pirates have covered the Run Line in 11 of their last 13 games (+9.90 Units / 52% ROI)
• The Pittsburgh Pirates have hit the 1st Five Innings (F5) Team Total Under in 17 of their last 25 games (+9.80 Units / 35% ROI)
• The Pittsburgh Pirates have hit the Moneyline in 15 of their last 21 games (+8.70 Units / 31% ROI)
• The Pittsburgh Pirates have hit the Game Total Over in 29 of their last 50 games at home (+8.35 Units / 15% ROI)
• The Pittsburgh Pirates have hit the Team Total Under in 28 of their last 50 games (+4.20 Units / 7% ROI)

Cardinals Against the Spread (ATS) Record

Against the spread this season, the Cardinals are 84-70 against the Run Line (-2.2 Units / -1.01% ROI).

• 76-81 when betting on the Moneyline for +0.1 Units / 0.06% ROI
• 73-77 when betting on the total runs Over for -12.35 Units / -7.12% ROI
• 77-73 when betting on the total runs Under for -3.25 Units / -1.89% ROI

Pirates Against the Spread (ATS) Record

Against the spread this season, the Pirates are 77-76 against the Run Line (-4.65 Units / -2.32% ROI).

• 80-77 when betting on the Moneyline for -7.4 Units / -3.81% ROI
• 80-70 when betting on the total runs Over for +3.1 Units / 1.79% ROI
• 70-80 when betting on the total runs Under for -17.65 Units / -10.24% ROI

Cardinals Keys to the Game vs. the Pirates

The Cardinals are just 28-18 (.609) when they’ve had 10 or more hits this season — 2nd lowest in MLB.

The Cardinals are 9-58 (.134) when trailing entering the 8th inning this season — 5th best in MLB.

The Cardinals are just 6-14 (.300) when tied entering the 8th inning this season — tied for 3rd lowest in MLB.

The Cardinals are just 104-53 (.662) when they’ve had 10 or more hits since the 2024 season — 3rd lowest in MLB.

Pirates Keys to the Game vs. the Cardinals

The Pirates are just 7-37 (.159) when allowing 10 or more hits this season — 4th lowest in MLB.

The Pirates are just 3-145 (.020) when trailing entering the 9th inning since the 2025 season — lowest in MLB.

The Pirates are just 24-99 (.195) when allowing 2 or more home runs since the 2024 season — lowest in MLB.

The Pirates are just 21-124 (.145) when allowing 10 or more hits since the 2024 season — 2nd lowest in MLB.

Cardinals Hitting Stats & Trends

Cardinals hitters are slugging just .357 at home this season — 2nd lowest in MLB.

Cardinals hitters have an OPS of just .662 (2,971 PA’s) at home this season — 2nd lowest in MLB.

The Cardinals are batting .275 when facing the starting pitcher for the 3rd time in a game this season — tied for 3rd best in MLB.

Cardinals hitters have an OBP of just .304 (2,971 PA’s) at home this season — 2nd lowest in MLB.

Pirates Hitting Stats & Trends

Pirates hitters have struck out in 25% of their PA’s against LHP this season — 2nd highest in MLB.

Pirates hitters have an OBP of .348 (3,036 PA’s) at home this season — tied for 2nd best in MLB.

Pirates hitters have an OPS of .753 (4,155 PA’s) against RHP this season — 4th best in MLB.

Pirates hitters have an OBP of .338 (4,155 PA’s) against RHP this season — 3rd best in MLB.

Cardinals Pitching Stats & Trends

The Cardinals pitchers have allowed their opponents to score first in just 37% of their games on the road this season — lowest in MLB.

Opponents have a groundball rate of 45% against Cardinals pitchers this season — 4th highest in MLB.

Cardinals pitchers have 185 three-pitch strikeouts this season — 3rd fewest in MLB.

Cardinals pitchers have a first-pitch strike rate of just 60% this season — tied for 5th lowest in MLB.

Pirates Pitching Stats & Trends

Pirates pitchers have walked 10% of batters when facing the leadoff batter in the inning this season — 4th highest in MLB.

The Pirates pitchers have allowed their opponents to score first in just 45% of their games this season — tied for 2nd lowest in MLB.

Pirates pitchers have allowed 150 home runs this season — tied for fewest in MLB.

The Pirates have won just 26% of games in which their opponents scored first this season — 3rd lowest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

Bet now on Cardinals vs Pirates and all games with BetMGM

Bet on MLB Odds at BetMGM

Sportsbook promos are always available at BetMGM. For new customers, check out the sportsbook welcome offer and BetMGM Refer a Friend. For existing customers, there are Odds Boosts, Parlay Boosts, contests and more.