• The Pirates are -165 favorites vs the Cardinals
• Cardinals vs Pirates Over / Under today: 7 Runs
• Cardinals / Pirates TV Channel: CATV | SNPT

The St. Louis Cardinals (+135) visit PNC Park to take on the Pittsburgh Pirates (-165) on September 24, 2026. First pitch is scheduled for 12:35 pm in Pittsburgh, PA.

This season, the Cardinals are 77-81 against the spread (ATS), while the Pirates are 77-77 ATS.

Cardinals vs Pirates Starting Pitchers Today:

• Cardinals starting pitcher: Kyle Leahy 10-5, 3.67 ERA
• Pirates starting pitcher: Paul Skenes 10-11, 3.95 ERA

Cardinals vs. Pirates Odds, Run Line, Over/Under & Moneyline

Cardinals vs Pirates Prediction for Today’s Game

Based on recent trends the model predicts the Pirates will win Thursday‘s MLB game with 57.0% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

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We’ve highlighted some favorite MLB player prop bets for Cardinals players for Thursday‘s game, looking at profitable historical betting trends:

Best Cardinals Player Prop Bets Today:

• Nathan Church has hit the Singles Over in 19 of his last 25 away games (+15.25 Units / 58% ROI)
• Nathan Church has hit the Hits Runs and RBIs Over in 19 of his last 25 away games (+14.55 Units / 48% ROI)
• Nathan Church has hit the Hits Over in 21 of his last 25 away games (+14.45 Units / 35% ROI)
• Kyle Leahy has hit the Earned Runs Under in 13 of his last 15 games (+11.55 Units / 58% ROI)
• Kyle Leahy has hit the Walks Allowed Under in 15 of his last 20 games (+10.65 Units / 39% ROI)

And here are some favorite MLB player prop bets for Pirates players for Thursday‘s game, looking at profitable historical betting trends:

Best Pirates Player Prop Best Bets Today:

• Brandon Lowe has hit the Home Runs Over in 5 of his last 8 games (+20.10 Units / 251% ROI)
• Brandon Lowe has hit the Hits Over in 21 of his last 25 games at home (+12.80 Units / 26% ROI)
• Jacob Gonzalez has hit the Hits Runs and RBIs Under in 13 of his last 15 games at home (+10.70 Units / 52% ROI)
• Konnor Griffin has hit the Total Bases Over in 16 of his last 25 games at home (+10.55 Units / 37% ROI)
• Bryan Reynolds has hit the Runs Under in his last 9 games at home (+9.00 Units / 58% ROI)

Cardinals Best Bets Today:

• The St. Louis Cardinals have hit the 1st Five Innings (F5) Moneyline in 29 of their last 50 away games (+18.35 Units / 34% ROI)
• The St. Louis Cardinals have covered the 1st Five Innings (F5) Run Line in 35 of their last 50 away games (+16.30 Units / 27% ROI)
• The St. Louis Cardinals have hit the Game Total Over in 24 of their last 35 games (+12.85 Units / 33% ROI)
• The St. Louis Cardinals have hit the Team Total Over in 31 of their last 50 away games (+10.30 Units / 18% ROI)
• The St. Louis Cardinals have hit the 1st Five Innings (F5) Team Total Under in 8 of their last 9 games (+7.05 Units / 61% ROI)

Pirates Best Bets Today:

• The Pittsburgh Pirates have hit the 1st Five Innings (F5) Team Total Under in 14 of their last 19 games (+9.95 Units / 46% ROI)
• The Pittsburgh Pirates have covered the Run Line in 11 of their last 14 games (+8.90 Units / 45% ROI)
• The Pittsburgh Pirates have hit the Game Total Under in 28 of their last 50 games (+8.25 Units / 15% ROI)
• The Pittsburgh Pirates have hit the Moneyline in 15 of their last 22 games (+7.35 Units / 25% ROI)
• The Pittsburgh Pirates have hit the Team Total Under in 29 of their last 50 games (+6.45 Units / 11% ROI)

Cardinals Against the Spread (ATS) Record

Against the spread this season, the Cardinals are 85-70 against the Run Line (-1.2 Units / -0.55% ROI).

• 77-81 when betting on the Moneyline for +1.25 Units / 0.72% ROI
• 73-78 when betting on the total runs Over for -13.45 Units / -7.7% ROI
• 78-73 when betting on the total runs Under for -2.25 Units / -1.3% ROI

Pirates Against the Spread (ATS) Record

Against the spread this season, the Pirates are 77-77 against the Run Line (-5.65 Units / -2.81% ROI).

• 80-78 when betting on the Moneyline for -8.75 Units / -4.47% ROI
• 80-71 when betting on the total runs Over for +2 Units / 1.15% ROI
• 71-80 when betting on the total runs Under for -16.65 Units / -9.6% ROI

Cardinals Keys to the Game vs. the Pirates

The Cardinals are just 29-18 (.617) when they’ve had 10 or more hits this season — 2nd lowest in MLB.

The Cardinals are 9-59 (.132) when trailing entering the 8th inning this season — 5th best in MLB.

The Cardinals are just 6-14 (.300) when tied entering the 8th inning this season — tied for 3rd lowest in MLB.

The Cardinals are just 13-25 (.342) when tied entering the 8th inning since the 2025 season — 2nd lowest in MLB.

Pirates Keys to the Game vs. the Cardinals

The Pirates are just 7-38 (.156) when allowing 10 or more hits this season — 4th lowest in MLB.

The Pirates are just 21-125 (.144) when allowing 10 or more hits since the 2024 season — 2nd lowest in MLB.

The Pirates were just 7-44 (.137) when allowing 10 or more hits in the 2024 season — 2nd lowest in MLB; League Avg: .250.

The Pirates are just 24-99 (.195) when allowing 2 or more home runs since the 2024 season — lowest in MLB.

Cardinals Hitting Stats & Trends

Cardinals hitters are slugging just .375 against RHP this season — 2nd lowest in MLB.

Cardinals hitters are slugging just .357 at home this season — 2nd lowest in MLB.

Cardinals hitters have struck out in just 19% of their PA’s against LHP this season — 3rd best in MLB.

Cardinals hitters have an OPS of just .662 (2,971 PA’s) at home this season — 2nd lowest in MLB.

Pirates Hitting Stats & Trends

Pirates hitters have struck out in 25% of their PA’s against LHP this season — 2nd highest in MLB.

Pirates hitters have an OBP of .347 (3,069 PA’s) at home this season — tied for 2nd best in MLB.

Pirates hitters have 130 extra-base hits out of 433 total hits (just 30%) against LHP this season — 3rd lowest in MLB.

Pirates hitters have an OBP of .330 (6,108 PA’s) this season — 4th best in MLB.

Cardinals Pitching Stats & Trends

Opponents have a groundball rate of 45% against Cardinals pitchers this season — tied for 3rd highest in MLB.

Cardinals pitchers have induced opposing hitters to ground into 133 double plays in 1,185 opportunities (11%) this season — tied for best in MLB.

Cardinals pitchers have a strikeout rate of just 20% with runners in scoring position this season — 5th lowest in MLB.

Cardinals pitchers have 187 three-pitch strikeouts this season — 3rd fewest in MLB.

Pirates Pitching Stats & Trends

Pirates pitchers have walked 10% of batters when facing the leadoff batter in the inning this season — 4th highest in MLB.

The Pirates pitchers have allowed division opponents to score first in just 41% of their games this season — 5th lowest in MLB.

The Pirates have won just 26% of games in which their opponents scored first this season — 3rd lowest in MLB.

Pirates pitchers have allowed 150 home runs this season — tied for fewest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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