• The Yankees are -150 favorites vs the Cardinals
• Cardinals vs Yankees Over / Under today: 8.5 Runs
• Cardinals / Yankees TV Channel: CATV | Amazon

The St. Louis Cardinals (+125) visit Yankee Stadium to take on the New York Yankees (-150) on August 5, 2026. First pitch is scheduled for 7:05 pm in Bronx, NY.

This season, the Cardinals are 56-58 against the spread (ATS), while the Yankees are 54-59 ATS.

Cardinals vs Yankees Starting Pitchers Today:

• Cardinals starting pitcher: Andre Pallante 11-6, 3.73 ERA
• Yankees starting pitcher: Will Warren 8-5, 4.13 ERA

Cardinals vs. Yankees Odds, Run Line, Over/Under & Moneyline

Cardinals vs Yankees Prediction for Today’s Game

Based on recent trends the model predicts the Yankees will win Wednesday‘s MLB game with 57.5% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Cardinals vs Yankees and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Cardinals players for Wednesday‘s game, looking at profitable historical betting trends:

Best Cardinals Player Prop Bets Today:

• JJ Wetherholt has hit the Hits Under in 15 of his last 25 games (+12.35 Units / 44% ROI)
• Alec Burleson has hit the Total Bases Over in 17 of his last 25 away games (+11.20 Units / 43% ROI)
• Andre Pallante has hit the Hits Allowed Under in his last 10 away games (+10.15 Units / 85% ROI)
• Jordan Walker has hit the Hits Runs and RBIs Over in 18 of his last 25 away games (+9.65 Units / 32% ROI)
• Kyle Leahy has hit the Earned Runs Under in his last 7 games (+7.00 Units / 73% ROI)

And here are some favorite MLB player prop bets for Yankees players for Wednesday‘s game, looking at profitable historical betting trends:

Best Yankees Player Prop Best Bets Today:

• Spencer Jones has hit the Home Runs Over in 3 of his last 7 games (+14.20 Units / 203% ROI)
• Jazz Chisholm has hit the Walks Under in 21 of his last 25 games at home (+13.25 Units / 25% ROI)
• Austin Wells has hit the Runs Under in 17 of his last 20 games at home (+10.85 Units / 26% ROI)
• Austin Wells has hit the Hits Runs and RBIs Under in 15 of his last 20 games at home (+10.65 Units / 46% ROI)
• Luis Garcia has hit the Hits Over in 13 of his last 20 games at home (+9.20 Units / 29% ROI)

Cardinals Best Bets Today:

• The St. Louis Cardinals have hit the Game Total Under in 30 of their last 45 games (+14.60 Units / 30% ROI)
• The St. Louis Cardinals have hit the 1st Five Innings (F5) Team Total Under in 14 of their last 16 games (+12.05 Units / 59% ROI)
• The St. Louis Cardinals have hit the 1st Five Innings (F5) Moneyline in 26 of their last 50 away games (+10.80 Units / 21% ROI)
• The St. Louis Cardinals have hit the Team Total Over in 31 of their last 50 away games (+10.05 Units / 17% ROI)
• The St. Louis Cardinals have hit the Moneyline in 27 of their last 50 away games (+8.90 Units / 17% ROI)

Yankees Best Bets Today:

• The New York Yankees have hit the Team Total Under in 23 of their last 30 games at home (+15.10 Units / 41% ROI)
• The New York Yankees have hit the 1st Five Innings (F5) Team Total Under in 26 of their last 40 games (+10.55 Units / 22% ROI)
• The New York Yankees have hit the Game Total Under in 25 of their last 40 games (+8.70 Units / 20% ROI)
• The New York Yankees have covered the 1st Five Innings (F5) Run Line in 7 of their last 8 games (+6.10 Units / 63% ROI)
• The New York Yankees have covered the Run Line in 13 of their last 22 games (+4.30 Units / 16% ROI)

Cardinals Against the Spread (ATS) Record

Against the spread this season, the Cardinals are 61-50 against the Run Line (-3.7 Units / -2.28% ROI).

• 56-58 when betting on the Moneyline for +2.35 Units / 1.92% ROI
• 45-64 when betting on the total runs Over for -25.8 Units / -20.53% ROI
• 64-45 when betting on the total runs Under for +14.3 Units / 11.42% ROI

Yankees Against the Spread (ATS) Record

Against the spread this season, the Yankees are 54-59 against the Run Line (-0.95 Units / -0.74% ROI).

• 64-50 when betting on the Moneyline for -7 Units / -4.16% ROI
• 49-61 when betting on the total runs Over for -18.55 Units / -14.73% ROI
• 61-49 when betting on the total runs Under for +7.25 Units / 5.8% ROI

Yankees vs Cardinals Home Run Prop Bets Today

Yankees vs Cardinals Total Hits Prop Bets Today

Yankees vs Cardinals Strikeout Prop Bets Today

Cardinals Keys to the Game vs. the Yankees

The Cardinals are just 6-11 (.353) when tied entering the 8th inning this season — 4th lowest in MLB.

The Cardinals are just 4-40 (.091) when trailing entering the 7th inning this season — tied for 4th lowest in MLB.

The Cardinals are just 6-11 (.353) when tied entering the 8th inning since the 2025 season — 4th lowest in MLB.

The Cardinals are just 4-40 (.091) when trailing entering the 7th inning since the 2025 season — tied for 4th lowest in MLB.

Yankees Keys to the Game vs. the Cardinals

The Yankees are 39-5 (.886) when they’ve hit 2 or more home runs this season — best in MLB.

The Yankees are 26-3 (.897) when they’ve had 10 or more hits this season — tied for best in MLB.

The Yankees are 40-5 (.889) when scoring 5 or more runs this season — 2nd best in MLB.

The Yankees are 18-2 (.900) when they’ve had 5 or more XBH this season — 4th best in MLB.

Cardinals Hitting Stats & Trends

Cardinals hitters have struck out in just 18% of their PA’s against LHP this season — 2nd best in MLB.

Cardinals hitters have an OPS of just .662 (2,187 PA’s) at home this season — 2nd lowest in MLB.

Cardinals hitters are slugging just .501 with the pitcher behind in the count this season — lowest in MLB.

Cardinals hitters have an OPS of just .694 (4,312 PA’s) this season — 5th lowest in MLB.

Yankees Hitting Stats & Trends

Yankees hitters have 204 extra-base hits out of 473 total hits (43%) against starting pitchers this season — best in MLB.

Yankees hitters have an OBP of just .226 (2,333 PA’s) with two-strikes this season — 2nd lowest in MLB.

The Yankees are batting just .130 on pitches out of the zone this season — 2nd lowest in MLB.

Yankees hitters have an OPS of .759 (1,360 PA’s) in innings 7-9 this season — 3rd best in MLB.

Cardinals Pitching Stats & Trends

Opponents have a groundball rate of 46% against Cardinals pitchers this season — tied for 3rd highest in MLB.

The Cardinals pitchers have allowed their opponents to score first in just 33% of their games on the road this season — 2nd lowest in MLB.

Opponents have a miss rate of just 22% against Cardinals pitchers this season — 3rd lowest in MLB.

Cardinals pitchers have a strikeout rate of just 18% with runners in scoring position this season — 3rd lowest in MLB.

Yankees Pitching Stats & Trends

Yankees pitchers have an ERA of 2.97 (554.2 IP) on the road this season — best in MLB.

Opponents have a groundball rate of 46% against Yankees pitchers this season — 2nd highest in MLB.

Yankees pitchers have a strikeout rate of 24% this season — 5th best in MLB.

Yankees pitchers have a strikeout rate of 46% with two-strikes this season — 3rd best in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

Bet now on Cardinals vs Yankees and all games with BetMGM

Bet on MLB Odds at BetMGM

Sportsbook promos are always available at BetMGM. For new customers, check out the sportsbook welcome offer and BetMGM Refer a Friend. For existing customers, there are Odds Boosts, Parlay Boosts, contests and more.