- The Chicago Cubs are -135 favorites vs the St. Louis Cardinals
- Chicago Cubs vs St. Louis Cardinals Over / Under today: 9 Runs
- Chicago Cubs / St. Louis Cardinals TV Channel: MARQ | FDMW
The Chicago Cubs (-145) visit Busch Stadium to take on the St. Louis Cardinals (+118) on Wednesday, June 25, 2025. First pitch is scheduled for 7:45pm EDT in St. Louis, MO, MO.
This season, the Chicago Cubs are 46-33 against the spread (ATS), while the St. Louis Cardinals are 45-35 ATS.
Chicago Cubs vs St. Louis Cardinals Starting Pitchers Today:
- Chicago Cubs starting pitcher: , ERA
- St. Louis Cardinals starting pitcher: , ERA
Chicago Cubs vs. St. Louis Cardinals Odds, Run Line, Over/Under & Moneyline
| Spread | Over / Under | Moneyline | |
| Chicago Cubs | -1.5 +118 | O 9 -120 | -145 |
| St. Louis Cardinals | +1.5 -145 | U 9 +100 | +118 |
Chicago Cubs vs St. Louis Cardinals Prediction for Today’s Game
Based on recent trends the model predicts the will win Wednesday‘s MLB game with confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.
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We’ve highlighted some favorite MLB player prop bets for Chicago Cubs players for Wednesday‘s game, looking at profitable historical betting trends:
Best Chicago Cubs Player Prop Bets Today:
- Nico Hoerner has hit the Home Runs Over in 1 of his last 4 games (+13.00 Units / 325% ROI)
- Dansby Swanson has hit the Runs Under in 19 of his last 25 games (+9.80 Units / 23% ROI)
- Nico Hoerner has hit the Hits Over in 9 of his last 10 games (+8.90 Units / 44% ROI)
- Dansby Swanson has hit the Singles Over in 16 of his last 25 away games (+8.65 Units / 33% ROI)
- Matthew Boyd has hit the Strikeouts Over in 17 of his last 25 games (+8.55 Units / 29% ROI)
And here are some favorite MLB player prop bets for St. Louis Cardinals players for Wednesday‘s game, looking at profitable historical betting trends:
Best St. Louis Cardinals Player Prop Best Bets Today:
- Alec Burleson has hit the Total Bases Over in 20 of his last 25 games (+17.85 Units / 58% ROI)
- Nolan Gorman has hit the Home Runs Over in 4 of his last 9 games at home (+14.60 Units / 162% ROI)
- Willson Contreras has hit the RBIs Over in 15 of his last 25 games (+12.75 Units / 51% ROI)
- Masyn Winn has hit the Runs Over in 14 of his last 20 games at home (+10.40 Units / 50% ROI)
- Alec Burleson has hit the Hits Over in 14 of his last 20 games (+7.25 Units / 21% ROI)
Chicago Cubs Best Bets Today:
- The Chicago Cubs have hit the 1st Five Innings (F5) Moneyline in 39 of their last 77 games (+10.35 Units / 9% ROI)
- The Chicago Cubs have hit the Moneyline in 44 of their last 73 games (+8.95 Units / 8% ROI)
- The Chicago Cubs have hit the Game Total Over in their last 6 games (+6.00 Units / 88% ROI)
- The Chicago Cubs have hit the 1st Five Innings (F5) Team Total Over in 6 of their last 7 games (+5.25 Units / 69% ROI)
- The Chicago Cubs have hit the Team Total Under in 16 of their last 26 games (+4.60 Units / 15% ROI)
St. Louis Cardinals Best Bets Today:
- The St. Louis Cardinals have covered the Run Line in 30 of their last 47 games (+14.15 Units / 23% ROI)
- The St. Louis Cardinals have hit the Team Total Over in 27 of their last 41 games at home (+12.97 Units / 28% ROI)
- The St. Louis Cardinals have hit the Moneyline in 35 of their last 57 games (+12.85 Units / 19% ROI)
- The St. Louis Cardinals have hit the Game Total Over in 17 of their last 28 games at home (+7.25 Units / 24% ROI)
- The St. Louis Cardinals have hit the 1st Five Innings (F5) Team Total Under in 19 of their last 31 games (+4.85 Units / 13% ROI)
Chicago Cubs Against the Spread (ATS) Record
Against the spread this season, the Chicago Cubs are 38-41 against the Run Line (-2.48 Units / -2.61% ROI).
- 46-33 when betting on the Moneyline for +6.85 Units / 5.91% ROI
- 41-33 when betting on the total runs Over for +5.25 Units / 6.09% ROI
- 33-41 when betting on the total runs Under for -12.15 Units / -13.87% ROI
St. Louis Cardinals Against the Spread (ATS) Record
Against the spread this season, the St. Louis Cardinals are 45-35 against the Run Line (+5.35 Units / 4.92% ROI).
- 44-36 when betting on the Moneyline for +7.2 Units / 7.75% ROI
- 43-33 when betting on the total runs Over for +6.8 Units / 7.73% ROI
- 33-43 when betting on the total runs Under for -14.25 Units / -16.19% ROI
St. Louis Cardinals vs Chicago Cubs Home Run Prop Bets Today
| Over | Under | |
|---|---|---|
| Seiya Suzuki (CHC) | 0.5 +325 | 0.5 -450 |
| Willson Contreras (STL) | 0.5 +375 | 0.5 -525 |
| Kyle Tucker (CHC) | 0.5 +400 | 0.5 -525 |
| Ian Happ (CHC) | 0.5 +400 | 0.5 -550 |
| Pete Crow-Armstrong (CHC) | 0.5 +425 | 0.5 -600 |
St. Louis Cardinals vs Chicago Cubs Total Hits Prop Bets Today
| Over | Under | |
|---|---|---|
| Masyn Winn (STL) | 0.5 -275 | 0.5 +195 |
| Nico Hoerner (CHC) | 0.5 -275 | 0.5 +200 |
| Kyle Tucker (CHC) | 0.5 -275 | 0.5 +195 |
| Willson Contreras (STL) | 0.5 -250 | 0.5 +180 |
| Brendan Donovan (STL) | 0.5 -250 | 0.5 +185 |
St. Louis Cardinals vs Chicago Cubs RBI Prop Bets Today
| Over | Under | |
|---|---|---|
| Seiya Suzuki (CHC) | 0.5 +125 | 0.5 -165 |
| Willson Contreras (STL) | 0.5 +135 | 0.5 -185 |
| Pete Crow-Armstrong (CHC) | 0.5 +135 | 0.5 -185 |
| Ian Happ (CHC) | 0.5 +150 | 0.5 -200 |
| Kyle Tucker (CHC) | 0.5 +155 | 0.5 -210 |
St. Louis Cardinals vs Chicago Cubs Strikeout Prop Bets Today
| Over | Under | |
|---|---|---|
| Erick Fedde (STL) | 3.5 -160 | 3.5 +125 |
| Matthew Boyd (CHC) | 4.5 -120 | 4.5 -110 |
Chicago Cubs Starting Pitcher Stats & Trends
starting pitcher – away
St. Louis Cardinals Starting Pitcher Stats & Trends
starting pitcher – home
Chicago Cubs Keys to the Game vs. the St. Louis Cardinals
keys to the game – away
St. Louis Cardinals Keys to the Game vs. the Chicago Cubs
keys to the game – home
Chicago Cubs Hitting Stats & Trends
team hitters – away
St. Louis Cardinals Hitting Stats & Trends
team hitters – home
Chicago Cubs Pitching Stats & Trends
team pitchers – away
St. Louis Cardinals Pitching Stats & Trends
team pitchers – home
More MLB Reading:
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