Chicago Cubs vs St. Louis Cardinals Prediction, Odds & Player Prop Bets Today – MLB, Jun 26

  • The Chicago Cubs are -135 favorites vs the St. Louis Cardinals
  • Chicago Cubs vs St. Louis Cardinals Over / Under today: 9 Runs
  • Chicago Cubs / St. Louis Cardinals TV Channel: MARQ | FDMW

The Chicago Cubs (-135) visit Busch Stadium to take on the St. Louis Cardinals (+115) on Thursday, June 26, 2025. First pitch is scheduled for 2:15pm EDT in St. Louis, MO, MO.

This season, the Chicago Cubs are 47-33 against the spread (ATS), while the St. Louis Cardinals are 45-36 ATS.

Chicago Cubs vs St. Louis Cardinals Starting Pitchers Today:

  • Chicago Cubs starting pitcher: , ERA
  • St. Louis Cardinals starting pitcher: , ERA

Chicago Cubs vs. St. Louis Cardinals Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Chicago Cubs-1.5 +120O 9 +100-135
St. Louis Cardinals +1.5 -145U 9 -120+115

Chicago Cubs vs St. Louis Cardinals Prediction for Today’s Game

Based on recent trends the model predicts the will win Thursday‘s MLB game with confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


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We’ve highlighted some favorite MLB player prop bets for Chicago Cubs players for Thursday‘s game, looking at profitable historical betting trends:

Best Chicago Cubs Player Prop Bets Today:

  • Ian Happ has hit the Home Runs Over in 4 of his last 7 games (+13.05 Units / 186% ROI)
  • Seiya Suzuki has hit the Runs Under in 18 of his last 25 games (+9.40 Units / 27% ROI)
  • Matt Shaw has hit the Hits Runs and RBIs Over in 14 of his last 20 away games (+8.90 Units / 38% ROI)
  • Dansby Swanson has hit the Hits Over in 19 of his last 25 away games (+8.85 Units / 20% ROI)
  • Dansby Swanson has hit the Singles Over in 16 of his last 25 away games (+8.60 Units / 32% ROI)

And here are some favorite MLB player prop bets for St. Louis Cardinals players for Thursday‘s game, looking at profitable historical betting trends:

Best St. Louis Cardinals Player Prop Best Bets Today:

  • Alec Burleson has hit the Total Bases Over in 19 of his last 25 games (+15.30 Units / 50% ROI)
  • Nolan Gorman has hit the Home Runs Over in 4 of his last 10 games at home (+13.60 Units / 136% ROI)
  • Willson Contreras has hit the RBIs Over in 14 of his last 25 games (+10.15 Units / 41% ROI)
  • Masyn Winn has hit the Runs Over in 16 of his last 25 games at home (+10.00 Units / 39% ROI)
  • Garrett Hampson has hit the Hits Under in 17 of his last 25 games (+8.80 Units / 32% ROI)
  • The Chicago Cubs have hit the 1st Five Innings (F5) Moneyline in 40 of their last 78 games (+11.35 Units / 10% ROI)
  • The Chicago Cubs have hit the Moneyline in 45 of their last 74 games (+9.95 Units / 9% ROI)
  • The Chicago Cubs have hit the 1st Five Innings (F5) Team Total Over in 7 of their last 8 games (+6.25 Units / 72% ROI)
  • The Chicago Cubs have hit the Game Total Under in 16 of their last 27 games (+6.25 Units / 21% ROI)
  • The Chicago Cubs have hit the Team Total Over in 43 of their last 75 games (+5.35 Units / 6% ROI)
  • The St. Louis Cardinals have covered the Run Line in 30 of their last 48 games (+12.90 Units / 21% ROI)
  • The St. Louis Cardinals have hit the Moneyline in 35 of their last 58 games (+11.85 Units / 17% ROI)
  • The St. Louis Cardinals have hit the Team Total Over in 27 of their last 42 games at home (+11.72 Units / 25% ROI)
  • The St. Louis Cardinals have hit the Game Total Over in 17 of their last 29 games at home (+6.05 Units / 19% ROI)
  • The St. Louis Cardinals have hit the 1st Five Innings (F5) Team Total Under in 20 of their last 32 games (+5.95 Units / 15% ROI)

Chicago Cubs Against the Spread (ATS) Record

Against the spread this season, the Chicago Cubs are 39-41 against the Run Line (-1.43 Units / -1.49% ROI).

  • 47-33 when betting on the Moneyline for +7.85 Units / 6.68% ROI
  • 41-34 when betting on the total runs Over for +4.05 Units / 4.63% ROI
  • 34-41 when betting on the total runs Under for -11.15 Units / -12.58% ROI

St. Louis Cardinals Against the Spread (ATS) Record

Against the spread this season, the St. Louis Cardinals are 45-36 against the Run Line (+4.1 Units / 3.73% ROI).

  • 44-37 when betting on the Moneyline for +6.2 Units / 6.61% ROI
  • 43-34 when betting on the total runs Over for +5.6 Units / 6.28% ROI
  • 34-43 when betting on the total runs Under for -13.25 Units / -14.88% ROI

St. Louis Cardinals vs Chicago Cubs Home Run Prop Bets Today

Over Under
Willson Contreras (STL) 0.5 +340 0.5 -450
Masyn Winn (STL) 0.5 +400 0.5 -550
Nolan Arenado (STL) 0.5 +425 0.5 -600
Seiya Suzuki (CHC) 0.5 +450 0.5 -625
Yohel Pozo (STL) 0.5 +475 0.5 -700

St. Louis Cardinals vs Chicago Cubs Total Hits Prop Bets Today

Over Under
Willson Contreras (STL) 0.5 -285 0.5 +210
Brendan Donovan (STL) 0.5 -275 0.5 +195
Dansby Swanson (CHC) 0.5 -275 0.5 +195
Nolan Arenado (STL) 0.5 -250 0.5 +185
Yohel Pozo (STL) 0.5 -250 0.5 +180

St. Louis Cardinals vs Chicago Cubs RBI Prop Bets Today

Over Under
Seiya Suzuki (CHC) 0.5 +110 0.5 -150
Willson Contreras (STL) 0.5 +125 0.5 -165
Pete Crow-Armstrong (CHC) 0.5 +135 0.5 -175
Kyle Tucker (CHC) 0.5 +150 0.5 -200
Dansby Swanson (CHC) 0.5 +150 0.5 -200

St. Louis Cardinals vs Chicago Cubs Strikeout Prop Bets Today

Over Under
Shota Imanaga (CHC) 3.5 -165 3.5 +130
Andre Pallante (STL) 3.5 -110 3.5 -120

starting pitcher – away

St. Louis Cardinals Starting Pitcher Stats & Trends

starting pitcher – home

Chicago Cubs Keys to the Game vs. the St. Louis Cardinals

keys to the game – away

St. Louis Cardinals Keys to the Game vs. the Chicago Cubs

keys to the game – home

team hitters – away

team hitters – home

team pitchers – away

team pitchers – home

More MLB Reading:


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Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.