Cleveland Guardians vs Athletics Prediction, Odds & Player Prop Bets Today – MLB, Jun 21

Oakland Athletics' Shea Langeliers runs up the first base line against the Houston Astros during the third inning of a baseball game Friday, May 19, 2023, in Houston.
(AP Photo/David J. Phillip)
  • The Cleveland Guardians are -125 favorites vs the Athletics
  • Cleveland Guardians vs Athletics Over / Under today: 9.5 Runs
  • Cleveland Guardians / Athletics TV Channel: GDTV | NSCA

The Cleveland Guardians (-125) visit Sutter Health Park to take on the Athletics (+105) on Saturday, June 21, 2025. First pitch is scheduled for 10:05pm EDT in Sacramento, CA, CA.

This season, the Cleveland Guardians are 37-37 against the spread (ATS), while the Athletics are 38-40 ATS.

Cleveland Guardians vs Athletics Starting Pitchers Today:

  • Cleveland Guardians starting pitcher: , ERA
  • Athletics starting pitcher: , ERA

Cleveland Guardians vs. Athletics Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Cleveland Guardians-1.5 +135O 9.5 -115-125
Athletics +1.5 -160U 9.5 -105+105

Cleveland Guardians vs Athletics Prediction for Today’s Game

Based on recent trends the model predicts the will win Saturday‘s MLB game with confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


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We’ve highlighted some favorite MLB player prop bets for Cleveland Guardians players for Saturday‘s game, looking at profitable historical betting trends:

Best Cleveland Guardians Player Prop Bets Today:

And here are some favorite MLB player prop bets for Athletics players for Saturday‘s game, looking at profitable historical betting trends:

Best Athletics Player Prop Best Bets Today:

Cleveland Guardians Against the Spread (ATS) Record

Against the spread this season, the Cleveland Guardians are 39-35 against the Run Line (-2.25 Units / -2.18% ROI).

  • 37-37 when betting on the Moneyline for +0.75 Units / 0.88% ROI
  • 31-39 when betting on the total runs Over for -10.85 Units / -13.51% ROI
  • 39-31 when betting on the total runs Under for +5 Units / 6.06% ROI

Athletics Against the Spread (ATS) Record

Against the spread this season, the Athletics are 38-40 against the Run Line (-9.65 Units / -9.47% ROI).

  • 32-46 when betting on the Moneyline for -12.45 Units / -14.34% ROI
  • 42-31 when betting on the total runs Over for +8.25 Units / 9.67% ROI
  • 31-42 when betting on the total runs Under for -15.25 Units / -17.66% ROI

Athletics vs Cleveland Guardians Home Run Prop Bets Today

Over Under
Kyle Manzardo (CLE) 0.5 +400 0.5 -525
Brent Rooker (ATH) 0.5 +400 0.5 -525
Lawrence Butler (ATH) 0.5 +400 0.5 -550
Tyler Soderstrom (ATH) 0.5 +425 0.5 -600
Jose Ramirez (CLE) 0.5 +425 0.5 -600

Athletics vs Cleveland Guardians Total Hits Prop Bets Today

Over Under
Brent Rooker (ATH) 0.5 -250 0.5 +195
Kyle Manzardo (CLE) 0.5 -220 0.5 +165
Lawrence Butler (ATH) 0.5 -220 0.5 +165
Tyler Soderstrom (ATH) 0.5 -200 0.5 +150
Lane Thomas (CLE) 0.5 -200 0.5 +145

Athletics vs Cleveland Guardians RBI Prop Bets Today

Over Under
Brent Rooker (ATH) 0.5 +140 0.5 -185
Jose Ramirez (CLE) 0.5 +145 0.5 -190
Carlos Santana (CLE) 0.5 +155 0.5 -210
Tyler Soderstrom (ATH) 0.5 +165 0.5 -220
Kyle Manzardo (CLE) 0.5 +165 0.5 -220

Athletics vs Cleveland Guardians Strikeout Prop Bets Today

Over Under
Mitch Spence (ATH) 4.5 +100 4.5 -130

starting pitcher – away

Athletics Starting Pitcher Stats & Trends

starting pitcher – home

Cleveland Guardians Keys to the Game vs. the Athletics

keys to the game – away

Athletics Keys to the Game vs. the Cleveland Guardians

keys to the game – home

team hitters – away

team hitters – home

team pitchers – away

team pitchers – home

More MLB Reading:


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Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.