Cubs vs Astros Prediction, Odds & Player Prop Bets Today – MLB, Jun 28

Houston Astros' Yordan Alvarez runs up the first base line against the Los Angeles Angels during the fourth inning of a baseball game Sunday, June 4, 2023, in Houston.
(AP Photo/David J. Phillip)
  • The Cubs are -102 favorites vs the Astros
  • Cubs vs Astros Over / Under today: 8.5 Runs
  • Cubs / Astros TV Channel: FOX

The Chicago Cubs (-102) visit Daikin Park to take on the Houston Astros (-118) on Saturday, June 28, 2025. First pitch is scheduled for 7:15pm EDT in Houston, TX.

This season, the Cubs are 48-34 against the spread (ATS), while the Astros are 42-40 ATS.

Cubs vs Astros Starting Pitchers Today:

  • Cubs starting pitcher: Colin Rea 4-3, 4.44 ERA
  • Astros starting pitcher: Lance McCullers 1-2, 4.80 ERA

Cubs vs. Astros Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Cubs-1.5 +155O 8.5 -115-102
Astros +1.5 -190U 8.5 -105-118

Cubs vs Astros Prediction for Today’s Game

Based on recent trends the model predicts the Astros will win Saturday‘s MLB game with 52.8% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


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We’ve highlighted some favorite MLB player prop bets for Cubs players for Saturday‘s game, looking at profitable historical betting trends:

Best Cubs Player Prop Bets Today:

  • Nico Hoerner has hit the Home Runs Over in 2 of his last 4 games (+24.00 Units / 600% ROI)
  • Seiya Suzuki has hit the Runs Under in 18 of his last 25 games (+9.40 Units / 27% ROI)
  • Michael Busch has hit the Total Bases Over in 17 of his last 25 away games (+9.10 Units / 29% ROI)
  • Dansby Swanson has hit the Hits Over in 19 of his last 25 away games (+8.85 Units / 19% ROI)
  • Dansby Swanson has hit the RBIs Under in his last 7 games (+7.00 Units / 54% ROI)

And here are some favorite MLB player prop bets for Astros players for Saturday‘s game, looking at profitable historical betting trends:

Best Astros Player Prop Best Bets Today:

  • Victor Caratini has hit the Home Runs Over in 3 of his last 6 games (+16.40 Units / 273% ROI)
  • Jeremy Pena has hit the Hits Over in 16 of his last 25 games at home (+13.60 Units / 38% ROI)
  • Jake Meyers has hit the Singles Over in 19 of his last 25 games (+12.35 Units / 43% ROI)
  • Jeremy Pena has hit the Total Bases Over in 16 of his last 25 games at home (+9.65 Units / 38% ROI)
  • Jeremy Pena has hit the Runs Over in 16 of his last 25 games (+7.50 Units / 27% ROI)
  • The Chicago Cubs have hit the 1st Five Innings (F5) Moneyline in 41 of their last 80 games (+11.20 Units / 10% ROI)
  • The Chicago Cubs have hit the Moneyline in 46 of their last 76 games (+9.95 Units / 9% ROI)
  • The Chicago Cubs have hit the Game Total Under in 17 of their last 29 games (+6.15 Units / 19% ROI)
  • The Chicago Cubs have hit the Team Total Over in 44 of their last 77 games (+5.05 Units / 5% ROI)
  • The Chicago Cubs have covered the 1st Five Innings (F5) Run Line in 43 of their last 78 games (+4.20 Units / 4% ROI)
  • The Houston Astros have hit the Moneyline in 28 of their last 36 games at home (+18.45 Units / 37% ROI)
  • The Houston Astros have hit the Team Total Under in 50 of their last 82 games (+14.75 Units / 15% ROI)
  • The Houston Astros have hit the Game Total Under in 30 of their last 49 games (+10.55 Units / 19% ROI)
  • The Houston Astros have hit the 1st Five Innings (F5) Team Total Over in 25 of their last 39 games at home (+9.10 Units / 19% ROI)
  • The Houston Astros have covered the Run Line in 22 of their last 38 games at home (+8.87 Units / 19% ROI)

Cubs Against the Spread (ATS) Record

Against the spread this season, the Cubs are 40-42 against the Run Line (-1.78 Units / -1.81% ROI).

  • 48-34 when betting on the Moneyline for +7.85 Units / 6.55% ROI
  • 42-35 when betting on the total runs Over for +3.95 Units / 4.41% ROI
  • 35-42 when betting on the total runs Under for -11.25 Units / -12.39% ROI

Astros Against the Spread (ATS) Record

Against the spread this season, the Astros are 42-40 against the Run Line (+3.57 Units / 3.5% ROI).

  • 49-33 when betting on the Moneyline for +9.65 Units / 8.97% ROI
  • 33-46 when betting on the total runs Over for -17.05 Units / -19.02% ROI
  • 46-33 when betting on the total runs Under for +9.8 Units / 10.78% ROI

Astros vs Cubs Home Run Prop Bets Today

Over Under
Seiya Suzuki (CHC) 0.5 +350 0.5 -450
Christian Walker (HOU) 0.5 +350 0.5 -450
Isaac Paredes (HOU) 0.5 +375 0.5 -500
Kyle Tucker (CHC) 0.5 +400 0.5 -550
Ian Happ (CHC) 0.5 +475 0.5 -700

Astros vs Cubs Total Hits Prop Bets Today

Over Under
Jose Altuve (HOU) 0.5 -275 0.5 +200
Jake Meyers (HOU) 0.5 -250 0.5 +190
Isaac Paredes (HOU) 0.5 -250 0.5 +185
Seiya Suzuki (CHC) 0.5 -225 0.5 +170
Kyle Tucker (CHC) 0.5 -225 0.5 +170

Astros vs Cubs RBI Prop Bets Today

Over Under
Seiya Suzuki (CHC) 0.5 +140 0.5 -185
Christian Walker (HOU) 0.5 +150 0.5 -200
Pete Crow-Armstrong (CHC) 0.5 +150 0.5 -200
Jake Meyers (HOU) 0.5 +160 0.5 -210
Victor Caratini (HOU) 0.5 +165 0.5 -220

Astros vs Cubs Strikeout Prop Bets Today

Over Under
Colin Rea (CHC) 3.5 -145 3.5 +110
Lance McCullers Jr. (HOU) 5.5 +135 5.5 -175

Left-handed batters are hitting .444 (12-for-27) against Colin Rea in his last two starts — 2nd highest in MLB over the last two weeks; League Avg: .233 — third Percentile.

Colin Rea has allowed an OPS of 1.242 (28 PA’s) vs left-handed batters in his last two starts — 2nd highest in MLB over the last two weeks; League Avg: .691 — third Percentile.

Opponents are hitting .389 (7-for-18) against Colin Rea when going through the lineup the first time in a game in his last two starts — 2nd highest in MLB over the last two weeks; League Avg: .216 — second Percentile.

Opponents are hitting .312 (15-for-48) against Colin Rea in his last two starts — 5th highest in MLB over the last two weeks; League Avg: .227 — sixth Percentile.

Astros Starting Pitcher Stats & Trends

Lance McCullers has allowed three-ball counts to 39% of batters he faced (18/46 PA’s) this month (2 games) — highest in MLB among starting pitchers with at least 9 total IP; League Avg: 19% — 0 Percentile.

Hitters have swung at 36% of Lance McCullers’ pitches (69/192) this month (2 games) — lowest in MLB among starting pitchers with at least 9 total IP; League Avg: 48% — 0 Percentile.

Opponents have a chase percentage of just 16% (15/95) against Lance McCullers this month (2 games) — lowest in MLB among starting pitchers with at least 9 total IP; League Avg: 29% — 0 Percentile.

Opponents are hitting just .154 (6-for-39) against Lance McCullers this month (2 games) — tied for 5th best in MLB among starting pitchers with at least 9 total IP; League Avg: .246 — 97th Percentile.

Cubs Keys to the Game vs. the Astros

The Cubs are 24-5 (.828) when they’ve had 10 or more hits this season — 5th best in MLB; League Avg: .745.

The Cubs are 48-34 (.585) this season — tied for 4th best in MLB; League Avg: .500.

The Cubs are 69-42 (.622) after a loss since last season — 2nd best in MLB; League Avg: .499.

The Cubs are 24-9 (.727) after a loss this season — 2nd best in MLB; League Avg: .491.

Astros Keys to the Game vs. the Cubs

The Astros were just 0-56 (.000) when trailing entering the 9th inning in the 2024 season — tied for lowest in MLB; League Avg: .050.

The Astros are 37-2 (.949) when leading entering the 8th inning this season — 5th best in MLB; League Avg: .907.

The Astros are 10-6 (.625) vs top 10 scoring offenses this season They play the Cubs (Ranks second runs scored) today.

The Astros were just 5-13 (.278) when tied entering the 8th inning in the 2024 season — 3rd lowest in MLB; League Avg: .500.

Cubs hitters are slugging .393 with two-strikes over the last 14 days — 2nd best in MLB; League Avg: .272.

Cubs hitters have drawn walks in 4% of their PA’s against pitchers who have thrown at least 80 pitches in a game this season — lowest in MLB; League Avg: 9%.

Cubs hitters have an OBP of just .206 (190 PA’s) against pitchers who have thrown at least 80 pitches in a game this season — lowest in MLB; League Avg: .319.

The Cubs are batting just .216 when facing the starting pitcher for the 3rd time in a game this season — lowest in MLB; League Avg: .255.

Astros hitters have put just 29% of balls in play to the right side of the field this season — lowest in MLB; League Avg: 38%.

Astros hitters averaged just 3.65 pitches per plate appearance against RHP in the 2024 season — lowest in MLB; League Avg: 3.89.

Astros hitters have put 47% of balls in play to the left side of the field this season — highest in MLB; League Avg: 38%.

Astros hitters averaged just 3.66 pitches per plate appearance in the 2024 season — lowest in MLB; League Avg: 3.89.

Cubs pitchers have a strikeout rate of just 32% with two-strikes over the last 14 days — 2nd lowest in MLB; League Avg: 42%.

Opponents have a miss rate of just 23% against Cubs pitchers this season — 2nd lowest in MLB; League Avg: 25%.

Cubs pitchers have a strikeout rate of just 38% with two-strikes this season — 2nd lowest in MLB; League Avg: 42%.

Cubs pitchers have walked 7% of batters this season — tied for 3rd best in MLB; League Avg: 9%.

Astros pitchers have a strikeout rate of 27% this season — best in MLB; League Avg: 22%.

Astros pitchers have a strikeout rate of 53% with two-strikes over the last 14 days — best in MLB; League Avg: 42%.

Astros pitchers have a strikeout rate of 53% with two-strikes this month (24 games) — best in MLB; League Avg: 42%.

Opponents have a miss rate of 28% against Astros pitchers since last season — 2nd best in MLB; League Avg: 25%.

More MLB Reading:


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Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.