• The Cubs are -120 favorites vs the Cardinals
• Cubs vs Cardinals Over / Under today: 10 Runs
• Cubs / Cardinals TV Channel: MARQ | CATV

The Chicago Cubs (-120) visit Busch Stadium to take on the St. Louis Cardinals (+100) on July 27, 2026. First pitch is scheduled for 7:45 pm in St. Louis, MO.

This season, the Cubs are 59-46 against the spread (ATS), while the Cardinals are 58-44 ATS.

Cubs vs Cardinals Starting Pitchers Today:

• Cubs starting pitcher: David Peterson 5-7, 6.02 ERA
• Cardinals starting pitcher: Hunter Dobbins 2-1, 3.18 ERA

Cubs vs. Cardinals Odds, Run Line, Over/Under & Moneyline

Cubs vs Cardinals Prediction for Today’s Game

Based on recent trends the model predicts the Cardinals will win Monday‘s MLB game with 52.9% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

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We’ve highlighted some favorite MLB player prop bets for Cubs players for Monday‘s game, looking at profitable historical betting trends:

Best Cubs Player Prop Bets Today:

• Carson Kelly has hit the Singles Under in 14 of his last 15 away games (+12.90 Units / 66% ROI)
• Seiya Suzuki has hit the RBIs Over in his last 6 games (+10.90 Units / 182% ROI)
• Seiya Suzuki has hit the Walks Under in 20 of his last 25 away games (+10.75 Units / 23% ROI)
• Seiya Suzuki has hit the Hits Runs and RBIs Over in 18 of his last 25 away games (+10.65 Units / 36% ROI)
• Seiya Suzuki has hit the Home Runs Over in 3 of his last 6 games (+9.55 Units / 159% ROI)

And here are some favorite MLB player prop bets for Cardinals players for Monday‘s game, looking at profitable historical betting trends:

Best Cardinals Player Prop Best Bets Today:

• Ivan Herrera has hit the Total Bases Under in 21 of his last 25 games at home (+15.45 Units / 37% ROI)
• Blaze Jordan has hit the Runs Under in his last 15 games at home (+15.00 Units / 44% ROI)
• Ivan Herrera has hit the Hits Under in 15 of his last 25 games at home (+10.75 Units / 32% ROI)
• Ivan Herrera has hit the Hits Runs and RBIs Under in 18 of his last 25 games at home (+10.55 Units / 38% ROI)
• Nelson Velazquez has hit the Singles Under in 13 of his last 15 games (+9.75 Units / 38% ROI)

Cubs Best Bets Today:

• The Chicago Cubs have covered the Run Line in 19 of their last 30 games (+13.25 Units / 38% ROI)
• The Chicago Cubs have hit the Moneyline in 15 of their last 20 away games (+10.80 Units / 49% ROI)
• The Chicago Cubs have hit the Team Total Over in 31 of their last 50 away games (+10.20 Units / 18% ROI)
• The Chicago Cubs have hit the 1st Five Innings (F5) Team Total Over in 18 of their last 30 games (+5.45 Units / 16% ROI)
• The Chicago Cubs have hit the Game Total Over in 18 of their last 30 games (+4.85 Units / 15% ROI)

Cardinals Best Bets Today:

• The St. Louis Cardinals have hit the Game Total Under in 18 of their last 22 games at home (+13.60 Units / 56% ROI)
• The St. Louis Cardinals have hit the Team Total Under in 15 of their last 21 games at home (+9.30 Units / 39% ROI)
• The St. Louis Cardinals have hit the 1st Five Innings (F5) Team Total Under in 12 of their last 17 games at home (+6.35 Units / 30% ROI)
• The St. Louis Cardinals have covered the 1st Five Innings (F5) Run Line in 30 of their last 50 games (+6.15 Units / 10% ROI)
• The St. Louis Cardinals have hit the 1st Five Innings (F5) Moneyline in 24 of their last 50 games (+5.00 Units / 9% ROI)

Cubs Against the Spread (ATS) Record

Against the spread this season, the Cubs are 47-57 against the Run Line (-7.95 Units / -6.45% ROI).

• 59-46 when betting on the Moneyline for +1.2 Units / 0.86% ROI
• 56-48 when betting on the total runs Over for +3.8 Units / 3.28% ROI
• 48-56 when betting on the total runs Under for -13.05 Units / -11.3% ROI

Cardinals Against the Spread (ATS) Record

Against the spread this season, the Cardinals are 58-44 against the Run Line (+2 Units / 1.35% ROI).

• 53-52 when betting on the Moneyline for +4.35 Units / 3.84% ROI
• 42-58 when betting on the total runs Over for -22.1 Units / -19.09% ROI
• 58-42 when betting on the total runs Under for +11.65 Units / 10.1% ROI

Cubs Keys to the Game vs. the Cardinals

The Cubs are 25-12 (.676) vs bottom 10 scoring offenses this season Today, they face the Cardinals (15th in runs scored).

The Cubs are 24-1 (.960) when they’ve had 5 or more XBH this season — 2nd best in MLB; League Avg: .791.

The Cubs are 4-43 (.085) when trailing entering the 9th inning this season — 5th best in MLB; League Avg: .051.

The Cubs are 44-3 (.936) when leading entering the 7th inning this season — 3rd best in MLB; League Avg: .864.

Cardinals Keys to the Game vs. the Cubs

The Cardinals were just 7-11 (.389) when tied entering the 8th inning in the 2025 season — tied for 5th lowest in MLB; League Avg: .500.

The Cardinals were 18-9 (.667) when tied entering the 7th inning in the 2024 season — tied for 3rd best in MLB; League Avg: .498.

The Cardinals were 69-1 (.986) when leading entering the 9th inning in the 2024 season — tied for 2nd best in MLB; League Avg: .949.

Cubs Hitting Stats & Trends

Cubs hitters have an OBP of .355 (1,129 PA’s) against LHP this season — best in MLB.

Cubs hitters have an OBP of .355 (2,051 PA’s) at home this season — best in MLB.

Cubs hitters have come to the plate with runners in scoring position in 1,208 of their 4,149 plate appearances (29%) this season — 2nd highest in MLB.

Cubs hitters have drawn walks in 12% of their PA’s when leading off an inning this season — best in MLB.

Cardinals Hitting Stats & Trends

Cardinals hitters have 184 extra-base hits out of 588 total hits (just 31%) against RHP this season — 3rd lowest in MLB.

Cardinals hitters have struck out in just 18% of their PA’s against LHP this season — 2nd best in MLB.

Cardinals hitters are slugging just .381 against RHP this season — 3rd lowest in MLB.

Cardinals hitters are slugging just .362 at home this season — 3rd lowest in MLB.

Cubs Pitching Stats & Trends

Opponents have a groundball batting average of just .218 against Cubs pitchers with runners on base this season — 2nd best in MLB.

Cubs pitchers have picked-off 16 runners from first base this season — most in MLB.

In games when their opponents have scored three or more runs in an inning, the Cubs have still managed to win 37% of the time this season — highest in MLB.

The Cubs pitchers have allowed division opponents to score first in 69% of their games this season — highest in MLB.

Cardinals Pitching Stats & Trends

The Cardinals pitchers have allowed their opponents to score first in just 33% of their games on the road this season — 2nd lowest in MLB.

Opponents have a miss rate of just 22% against Cardinals pitchers this season — 2nd lowest in MLB.

Cardinals pitchers have allowed an average Exit Velocity of 89.8 MPH (2,740 batted balls) this season — tied for highest in MLB.

Cardinals pitchers have a strikeout rate of just 39% with two-strikes this season — 5th lowest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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