• The Cubs are -115 favorites vs the Cardinals
• Cubs vs Cardinals Over / Under today: 9 Runs
• Cubs / Cardinals TV Channel: MARQ | CATV | TBS

The Chicago Cubs (-115) visit Busch Stadium to take on the St. Louis Cardinals (-105) on July 28, 2026. First pitch is scheduled for 7:45 pm in St. Louis, MO.

This season, the Cubs are 60-46 against the spread (ATS), while the Cardinals are 58-45 ATS.

Cubs vs Cardinals Starting Pitchers Today:

• Cubs starting pitcher: Colin Rea 7-7, 4.84 ERA
• Cardinals starting pitcher: Michael McGreevy 4-8, 3.11 ERA

Cubs vs. Cardinals Odds, Run Line, Over/Under & Moneyline

Cubs vs Cardinals Prediction for Today’s Game

Based on recent trends the model predicts the Cardinals will win Tuesday‘s MLB game with 53.4% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Cubs vs Cardinals and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Cubs players for Tuesday‘s game, looking at profitable historical betting trends:

Best Cubs Player Prop Bets Today:

• Alex Bregman has hit the Home Runs Over in 3 of his last 5 away games (+12.80 Units / 256% ROI)
• Seiya Suzuki has hit the Hits Runs and RBIs Over in 19 of his last 25 games (+12.20 Units / 40% ROI)
• Carson Kelly has hit the Singles Under in 19 of his last 25 away games (+11.35 Units / 34% ROI)
• Seiya Suzuki has hit the Runs Over in 17 of his last 25 games (+10.80 Units / 39% ROI)
• Seiya Suzuki has hit the Walks Under in 20 of his last 25 away games (+10.75 Units / 23% ROI)

And here are some favorite MLB player prop bets for Cardinals players for Tuesday‘s game, looking at profitable historical betting trends:

Best Cardinals Player Prop Best Bets Today:

• Bryan Torres has hit the Home Runs Over in 2 of his last 7 games at home (+18.00 Units / 257% ROI)
• Blaze Jordan has hit the Runs Under in 22 of his last 25 games (+16.15 Units / 29% ROI)
• Jimmy Crooks III has hit the Hits Runs and RBIs Under in 12 of his last 15 games (+9.40 Units / 48% ROI)
• JJ Wetherholt has hit the Hits Under in 14 of his last 25 games at home (+9.35 Units / 32% ROI)
• Blaze Jordan has hit the Total Bases Under in 16 of his last 25 games (+9.30 Units / 30% ROI)

Cubs Best Bets Today:

• The Chicago Cubs have covered the Run Line in 16 of their last 21 away games (+13.40 Units / 49% ROI)
• The Chicago Cubs have hit the Moneyline in 16 of their last 21 away games (+11.80 Units / 51% ROI)
• The Chicago Cubs have hit the Team Total Over in 31 of their last 50 away games (+10.20 Units / 18% ROI)
• The Chicago Cubs have hit the 1st Five Innings (F5) Team Total Over in 14 of their last 21 away games (+6.35 Units / 25% ROI)
• The Chicago Cubs have hit the Game Total Over in 18 of their last 30 games (+4.85 Units / 15% ROI)

Cardinals Best Bets Today:

• The St. Louis Cardinals have hit the Game Total Under in 18 of their last 23 games at home (+12.40 Units / 49% ROI)
• The St. Louis Cardinals have hit the Team Total Under in 16 of their last 22 games at home (+10.30 Units / 41% ROI)
• The St. Louis Cardinals have hit the 1st Five Innings (F5) Team Total Under in 13 of their last 18 games at home (+7.35 Units / 33% ROI)
• The St. Louis Cardinals have covered the 1st Five Innings (F5) Run Line in 26 of their last 45 games at home (+4.75 Units / 9% ROI)
• The St. Louis Cardinals have hit the 1st Five Innings (F5) Moneyline in 24 of their last 50 games (+3.90 Units / 7% ROI)

Cubs Against the Spread (ATS) Record

Against the spread this season, the Cubs are 48-57 against the Run Line (-6.65 Units / -5.35% ROI).

• 60-46 when betting on the Moneyline for +2.2 Units / 1.56% ROI
• 57-48 when betting on the total runs Over for +4.8 Units / 4.11% ROI
• 48-57 when betting on the total runs Under for -14.25 Units / -12.22% ROI

Cardinals Against the Spread (ATS) Record

Against the spread this season, the Cardinals are 58-45 against the Run Line (+0.5 Units / 0.33% ROI).

• 53-53 when betting on the Moneyline for +3.35 Units / 2.93% ROI
• 43-58 when betting on the total runs Over for -21.1 Units / -18.07% ROI
• 58-43 when betting on the total runs Under for +10.45 Units / 8.97% ROI

Cardinals vs Cubs Home Run Prop Bets Today

Cardinals vs Cubs Total Hits Prop Bets Today

Cardinals vs Cubs Strikeout Prop Bets Today

Cubs Keys to the Game vs. the Cardinals

The Cubs are 25-12 (.676) vs bottom 10 scoring offenses this season Today, they face the Cardinals (16th in runs scored).

The Cubs are 32-4 (.889) when they’ve had 10 or more hits this season — 3rd best in MLB; League Avg: .755.

The Cubs are just 6-16 (.273) when their opponents score in the first inning this season — 4th lowest in MLB; League Avg: .371.

The Cubs are 25-1 (.962) when they’ve had 5 or more XBH this season — 2nd best in MLB; League Avg: .792.

Cardinals Keys to the Game vs. the Cubs

The Cardinals are just 4-37 (.098) when trailing entering the 7th inning this season — tied for 4th lowest in MLB; League Avg: .137.

The Cardinals are just 4-37 (.098) when trailing entering the 7th inning since the 2025 season — tied for 4th lowest in MLB; League Avg: .137.

The Cardinals were 18-9 (.667) when tied entering the 7th inning in the 2024 season — tied for 3rd best in MLB; League Avg: .498.

The Cardinals are just 4-37 (.098) when trailing entering the 7th inning since the 2024 season — tied for 4th lowest in MLB; League Avg: .137.

Cubs Hitting Stats & Trends

The Cubs have scored first in just 33% of their games against division opponents this season — 2nd lowest in MLB.

The Cubs have answered-back in 37% of innings after an opponent scores in late innings this season — 2nd highest in MLB.

The Cubs have answered-back in 37% of innings after an opponent scores this season — 2nd highest in MLB.

The Cubs have won 73% of games in which they have scored first this season — 5th highest in MLB.

Cardinals Hitting Stats & Trends

The Cardinals have scored first in 67% of their road games this season — 2nd highest in MLB.

The Cardinals have hit 1,135 balls in play with an exit velocity of 95 MPH or greater this season — 2nd most in MLB.

The Cardinals have answered-back in just 20% of innings after an opponent scores in late innings this season — lowest in MLB.

The Cardinals have answered-back in just 24% of innings after an opponent scores this season — lowest in MLB.

Cubs Pitching Stats & Trends

In games when their opponents have scored three or more runs in an inning, the Cubs have still managed to win 37% of the time this season — highest in MLB.

Cubs pitchers have picked-off 16 runners this season — most in MLB.

Cubs pitchers have picked-off 16 runners from first base this season — most in MLB.

Cubs pitchers have allowed a run just 25% of the time after their offense scores this season — 5th lowest in MLB.

Cardinals Pitching Stats & Trends

The Cardinals pitchers have allowed their opponents to score first in just 33% of their games on the road this season — 2nd lowest in MLB.

Opponents have a groundball rate of 46% against Cardinals pitchers this season — 4th highest in MLB.

The Cardinals pitchers have allowed an average Exit Velocity of 89.8 MPH this season (2,771 balls in play) — tied for highest in MLB

Cardinals pitchers have allowed an average Exit Velocity of 89.8 MPH (2,771 batted balls) this season — tied for highest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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