• The Cubs are -115 favorites vs the Cardinals
• Cubs vs Cardinals Over / Under today: 8.5 Runs
• Cubs / Cardinals TV Channel: NBC | PEAC

The Chicago Cubs (-115) visit Busch Stadium to take on the St. Louis Cardinals (-105) on May 31, 2026. First pitch is scheduled for 7:20 pm in St. Louis, MO.

This season, the Cubs are 32-27 against the spread (ATS), while the Cardinals are 33-22 ATS.

Cubs vs Cardinals Starting Pitchers Today:

• Cubs starting pitcher: Jordan Wicks 0-1, 16.63 ERA
• Cardinals starting pitcher: Matthew Liberatore 2-3, 4.77 ERA

Cubs vs. Cardinals Odds, Run Line, Over/Under & Moneyline

Cubs vs Cardinals Prediction for Today’s Game

Based on recent trends the model predicts the Cardinals will win Sunday‘s MLB game with 51.0% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Cubs vs Cardinals and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Cubs players for Sunday‘s game, looking at profitable historical betting trends:

Best Cubs Player Prop Bets Today:

• Ian Happ has hit the Home Runs Over in 4 of his last 10 away games (+16.50 Units / 165% ROI)
• Nico Hoerner has hit the Runs Under in 17 of his last 20 away games (+12.85 Units / 43% ROI)
• Alex Bregman has hit the Hits Over in 14 of his last 15 away games (+11.95 Units / 38% ROI)
• Alex Bregman has hit the Singles Over in 16 of his last 20 games (+11.60 Units / 52% ROI)
• Dansby Swanson has hit the Hits Runs and RBIs Under in 18 of his last 25 games (+10.20 Units / 31% ROI)

And here are some favorite MLB player prop bets for Cardinals players for Sunday‘s game, looking at profitable historical betting trends:

Best Cardinals Player Prop Best Bets Today:

• Alec Burleson has hit the Runs Under in 21 of his last 25 games at home (+14.30 Units / 33% ROI)
• Pedro Pages has hit the Home Runs Over in 2 of his last 9 games at home (+11.00 Units / 122% ROI)
• Thomas Saggese has hit the Hits Runs and RBIs Under in 18 of his last 25 games (+8.90 Units / 25% ROI)
• Victor Scott II has hit the Singles Under in 19 of his last 25 games (+8.75 Units / 19% ROI)
• Alec Burleson has hit the RBIs Over in 11 of his last 20 games at home (+8.70 Units / 44% ROI)

Cubs Best Bets Today:

• The Chicago Cubs have hit the 1st Five Innings (F5) Team Total Under in 15 of their last 20 games (+9.95 Units / 41% ROI)
• The Chicago Cubs have hit the Game Total Over in 29 of their last 50 games (+7.25 Units / 13% ROI)
• The Chicago Cubs have hit the Team Total Over in 29 of their last 50 games (+6.60 Units / 12% ROI)
• The Chicago Cubs have hit the Moneyline in 26 of their last 45 games (+4.95 Units / 9% ROI)
• The Chicago Cubs have covered the Run Line in 3 of their last 5 games (+0.60 Units / 8% ROI)

Cardinals Best Bets Today:

• The St. Louis Cardinals have hit the Game Total Under in 22 of their last 35 games (+9.95 Units / 26% ROI)
• The St. Louis Cardinals have covered the 1st Five Innings (F5) Run Line in 25 of their last 40 games (+7.65 Units / 16% ROI)
• The St. Louis Cardinals have hit the Moneyline in 22 of their last 40 games (+7.50 Units / 18% ROI)
• The St. Louis Cardinals have hit the Team Total Under in 17 of their last 25 games at home (+7.40 Units / 25% ROI)
• The St. Louis Cardinals have hit the 1st Five Innings (F5) Team Total Under in 29 of their last 50 games at home (+7.20 Units / 12% ROI)

Cubs Against the Spread (ATS) Record

Against the spread this season, the Cubs are 24-35 against the Run Line (-12.25 Units / -17.51% ROI).

• 32-27 when betting on the Moneyline for -1.4 Units / -1.76% ROI
• 33-25 when betting on the total runs Over for +6.1 Units / 9.41% ROI
• 25-33 when betting on the total runs Under for -11.05 Units / -16.95% ROI

Cardinals Against the Spread (ATS) Record

Against the spread this season, the Cardinals are 33-22 against the Run Line (+2.35 Units / 2.85% ROI).

• 30-26 when betting on the Moneyline for +8.55 Units / 14.86% ROI
• 24-29 when betting on the total runs Over for -7.9 Units / -12.85% ROI
• 29-24 when betting on the total runs Under for +2.4 Units / 3.88% ROI

Cardinals vs Cubs Home Run Prop Bets Today

Cardinals vs Cubs Total Hits Prop Bets Today

Cardinals vs Cubs Strikeout Prop Bets Today

Cubs Keys to the Game vs. the Cardinals

The Cubs are 26-0 (1.000) when leading entering the 8th inning this season — tied for best in MLB; League Avg: .893.

The Cubs are 24-0 (1.000) when leading entering the 7th inning this season — tied for best in MLB; League Avg: .859.

The Cubs are 9-2 (.818) when they’ve scored in the first inning this season — 2nd best in MLB; League Avg: .645.

The Cubs are 21-10 (.677) after a win this season — 2nd best in MLB; League Avg: .532.

Cardinals Keys to the Game vs. the Cubs

The Cardinals are 17-12 (.586) vs top 10 scoring offenses this season Today, they face the Cubs (seventh in runs scored).

The Cardinals are 3-23 (.115) when trailing entering the 9th inning this season — 4th best in MLB; League Avg: .056.

The Cardinals are 11-3 (.786) when they’ve scored in the first inning this season — 5th best in MLB; League Avg: .645.

The Cardinals are just 9-89 (.092) when trailing entering the 7th inning since the 2025 season — 5th lowest in MLB; League Avg: .129.

Cubs Hitting Stats & Trends

Cubs hitters have drawn walks in 12% of their PA’s against RHP this season — 2nd best in MLB.

Cubs hitters have put 41% of their swings in play on pitches 95 mph or greater this season — highest in MLB.

Cubs hitters have drawn walks in 14% of their PA’s when leading off an inning this season — best in MLB.

Cubs hitters have an OBP of .337 (2,325 PA’s) this season — 2nd best in MLB.

Cardinals Hitting Stats & Trends

Cardinals hitters have struck out in just 17% of their PA’s against LHP this season — best in MLB.

Cardinals hitters have an OBP of just .309 (566 PA’s) with runners in scoring position this season — 2nd lowest in MLB.

The Cardinals are batting just .209 with two outs this season — 4th lowest in MLB.

The Cardinals are batting just .223 with runners in scoring position this season — lowest in MLB.

Cubs Pitching Stats & Trends

Opponents have a groundball batting average of just .194 against Cubs pitchers with runners on base this season — best in MLB.

The Cubs pitchers have allowed an average Exit Velocity of 90.1 MPH this season (1,463 balls in play) — tied for highest in MLB

Cubs pitchers have walked 8% of batters this season — 5th best in MLB.

Cubs pitchers have allowed an average Exit Velocity of 90.1 MPH (1,463 batted balls) this season — tied for highest in MLB.

Cardinals Pitching Stats & Trends

Cardinals pitchers have a strikeout rate of just 16% with runners in scoring position this season — lowest in MLB.

Opponents have a miss rate of just 23% against Cardinals pitchers this season — 3rd lowest in MLB.

Cardinals pitchers have a strikeout rate of just 20% this season — tied for 3rd lowest in MLB.

Cardinals pitchers have a strikeout rate of just 38% with two-strikes this season — 3rd lowest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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