• The Cubs are -110 favorites vs the Diamondbacks
• Cubs vs Diamondbacks Over / Under today: 8 Runs
• Cubs / Diamondbacks TV Channel: MARQ | DBTV

The Chicago Cubs (-110) visit Chase Field to take on the Arizona Diamondbacks (-110) on August 25, 2026. First pitch is scheduled for 9:40 pm in Phoenix, AZ.

This season, the Cubs are 76-56 against the spread (ATS), while the Diamondbacks are 70-58 ATS.

Cubs vs Diamondbacks Starting Pitchers Today:

• Cubs starting pitcher: Clay Holmes 5-6, 2.50 ERA
• Diamondbacks starting pitcher: Brandon Pfaadt 7-1, 3.39 ERA

Cubs vs. Diamondbacks Odds, Run Line, Over/Under & Moneyline

Cubs vs Diamondbacks Prediction for Today’s Game

Based on recent trends the model predicts the Diamondbacks will win Tuesday‘s MLB game with 54.1% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

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We’ve highlighted some favorite MLB player prop bets for Cubs players for Tuesday‘s game, looking at profitable historical betting trends:

Best Cubs Player Prop Bets Today:

• Alex Bregman has hit the Home Runs Over in 4 of his last 7 away games (+20.60 Units / 294% ROI)
• Pete Crow-Armstrong has hit the Singles Under in 20 of his last 25 away games (+13.10 Units / 39% ROI)
• Alex Bregman has hit the Runs Over in 11 of his last 15 away games (+9.60 Units / 63% ROI)
• Nico Hoerner has hit the Hits Over in 11 of his last 15 away games (+9.35 Units / 37% ROI)
• Pete Crow-Armstrong has hit the RBIs Over in 11 of his last 20 away games (+8.80 Units / 44% ROI)

And here are some favorite MLB player prop bets for Diamondbacks players for Tuesday‘s game, looking at profitable historical betting trends:

Best Diamondbacks Player Prop Best Bets Today:

• Corbin Carroll has hit the Singles Under in 20 of his last 25 games at home (+12.75 Units / 35% ROI)
• Nolan Arenado has hit the Home Runs Over in 3 of his last 10 games at home (+12.60 Units / 126% ROI)
• Lars Nootbaar has hit the Hits Runs and RBIs Under in 19 of his last 25 games (+12.30 Units / 38% ROI)
• Corbin Carroll has hit the Walks Over in 14 of his last 25 games (+10.55 Units / 42% ROI)
• Lars Nootbaar has hit the Total Bases Under in 17 of his last 25 games (+9.90 Units / 31% ROI)

Cubs Best Bets Today:

• The Chicago Cubs have covered the Run Line in 32 of their last 50 games (+19.90 Units / 34% ROI)
• The Chicago Cubs have hit the Team Total Over in 28 of their last 40 away games (+14.30 Units / 30% ROI)
• The Chicago Cubs have hit the Moneyline in 24 of their last 35 away games (+11.80 Units / 28% ROI)
• The Chicago Cubs have hit the Game Total Over in 11 of their last 16 away games (+6.60 Units / 37% ROI)
• The Chicago Cubs have hit the 1st Five Innings (F5) Moneyline in 16 of their last 35 away games (+5.35 Units / 12% ROI)

Diamondbacks Best Bets Today:

• The Arizona Diamondbacks have hit the Moneyline in 24 of their last 40 games (+11.00 Units / 23% ROI)
• The Arizona Diamondbacks have covered the 1st Five Innings (F5) Run Line in 19 of their last 30 games at home (+7.15 Units / 21% ROI)
• The Arizona Diamondbacks have hit the Game Total Under in 28 of their last 50 games at home (+7.15 Units / 13% ROI)
• The Arizona Diamondbacks have hit the 1st Five Innings (F5) Team Total Under in 30 of their last 50 games at home (+6.40 Units / 11% ROI)
• The Arizona Diamondbacks have hit the Team Total Over in 19 of their last 30 games at home (+5.50 Units / 15% ROI)

Cubs Against the Spread (ATS) Record

Against the spread this season, the Cubs are 64-66 against the Run Line (+2.1 Units / 1.36% ROI).

• 76-56 when betting on the Moneyline for +4.75 Units / 2.67% ROI
• 71-59 when betting on the total runs Over for +6.8 Units / 4.68% ROI
• 59-71 when betting on the total runs Under for -18.55 Units / -12.77% ROI

Diamondbacks Against the Spread (ATS) Record

Against the spread this season, the Diamondbacks are 70-58 against the Run Line (+1 Units / 0.57% ROI).

• 69-63 when betting on the Moneyline for +7.1 Units / 4.58% ROI
• 57-69 when betting on the total runs Over for -19.05 Units / -13.06% ROI
• 69-57 when betting on the total runs Under for +6.75 Units / 4.67% ROI

Diamondbacks vs Cubs Home Run Prop Bets Today

Diamondbacks vs Cubs Total Hits Prop Bets Today

Diamondbacks vs Cubs Strikeout Prop Bets Today

Cubs Keys to the Game vs. the Diamondbacks

The Cubs are 6-51 (.105) when trailing entering the 9th inning this season — best in MLB.

The Cubs are 18-22 (.450) when allowing 10 or more hits this season — best in MLB.

The Cubs are 41-5 (.891) when they’ve had 10 or more hits this season — tied for 2nd best in MLB.

The Cubs are 34-3 (.919) when they’ve had 5 or more XBH this season — 3rd best in MLB.

Diamondbacks Keys to the Game vs. the Cubs

The Diamondbacks are 60-0 (1.000) when leading entering the 9th inning this season — tied for best in MLB.

The Diamondbacks are just 110-25 (.815) when leading entering the 7th inning since the 2025 season — 3rd lowest in MLB.

The Diamondbacks are 8-119 (.063) when trailing entering the 9th inning since the 2025 season — 5th best in MLB.

The Diamondbacks were just 67-7 (.905) when leading entering the 9th inning in the 2025 season — 2nd lowest in MLB; League Avg: .956.

Cubs Hitting Stats & Trends

Cubs hitters are slugging .452 against LHP this season — tied for best in MLB.

Cubs hitters have an OBP of .356 (1,382 PA’s) against LHP this season — best in MLB.

Cubs hitters have an OPS of .809 (1,382 PA’s) against LHP this season — best in MLB.

Cubs hitters have drawn walks in 11% of their PA’s this season — best in MLB.

Diamondbacks Hitting Stats & Trends

The Diamondbacks are batting .281 against LHP this season — best in MLB.

Diamondbacks hitters have struck out in just 18% of their PA’s against LHP this season — best in MLB.

Diamondbacks hitters are slugging .452 against LHP this season — tied for best in MLB.

The Diamondbacks are batting .298 in lefty-lefty matchups this season — best in MLB.

Cubs Pitching Stats & Trends

Cubs pitchers have picked-off 21 runners from first base this season — most in MLB.

Opponents have a groundball batting average of just .206 against Cubs pitchers with runners on base this season — best in MLB.

Opponents have a groundball batting average of just .219 against Cubs pitchers this season — best in MLB.

In games when their opponents have scored three or more runs in an inning, the Cubs have still managed to win 37% of the time this season — highest in MLB.

Diamondbacks Pitching Stats & Trends

Diamondbacks pitchers have a strikeout rate of just 18% this season — 2nd lowest in MLB.

Opponents have a miss rate of just 22% against Diamondbacks pitchers this season — 2nd lowest in MLB.

Diamondbacks pitchers have a strikeout rate of just 38% with two-strikes this season — tied for 2nd lowest in MLB.

Diamondbacks pitchers have a strikeout rate of just 17% with runners in scoring position this season — 2nd lowest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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