• The Cubs are -110 favorites vs the Padres
• Cubs vs Padres Over / Under today: 8 Runs
• Cubs / Padres TV Channel: MARQ | PDTV

The Chicago Cubs (-110) visit Petco Park to take on the San Diego Padres (-110) on April 27, 2026. First pitch is scheduled for 9:40 pm in San Diego, CA.

This season, the Cubs are 17-11 against the spread (ATS), while the Padres are 16-10 ATS.

Cubs vs Padres Starting Pitchers Today:

• Cubs starting pitcher: Matthew Boyd 1-1, 5.93 ERA
• Padres starting pitcher: Randy Vasquez 2-0, 1.91 ERA

Cubs vs. Padres Odds, Run Line, Over/Under & Moneyline

Cubs vs Padres Prediction for Today’s Game

Based on recent trends the model predicts the Padres will win Monday‘s MLB game with 52.4% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Cubs vs Padres and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Cubs players for Monday‘s game, looking at profitable historical betting trends:

Best Cubs Player Prop Bets Today:

• Dansby Swanson has hit the Home Runs Over in 4 of his last 10 away games (+19.00 Units / 190% ROI)
• Moises Ballesteros has hit the Hits Runs and RBIs Over in 18 of his last 25 games (+11.65 Units / 40% ROI)
• Alex Bregman has hit the Walks Over in 15 of his last 25 away games (+11.18 Units / 45% ROI)
• Seiya Suzuki has hit the Total Bases Over in 17 of his last 25 games (+10.80 Units / 36% ROI)
• Alex Bregman has hit the Runs Under in 19 of his last 25 games (+10.80 Units / 28% ROI)

And here are some favorite MLB player prop bets for Padres players for Monday‘s game, looking at profitable historical betting trends:

Best Padres Player Prop Best Bets Today:

• Xander Bogaerts has hit the Home Runs Over in 2 of his last 6 games at home (+11.50 Units / 192% ROI)
• Jake Cronenworth has hit the Total Bases Under in 18 of his last 25 games (+10.90 Units / 33% ROI)
• Jackson Merrill has hit the Runs Over in 14 of his last 20 games at home (+10.60 Units / 52% ROI)
• Jackson Merrill has hit the Hits Runs and RBIs Over in 18 of his last 25 games at home (+9.40 Units / 30% ROI)
• Jake Cronenworth has hit the Hits Under in 15 of his last 25 games (+8.75 Units / 33% ROI)

Cubs Best Bets Today:

• The Chicago Cubs have hit the Team Total Over in 15 of their last 20 games (+10.15 Units / 44% ROI)
• The Chicago Cubs have hit the Moneyline in 10 of their last 12 games (+8.75 Units / 61% ROI)
• The Chicago Cubs have hit the Game Total Over in 14 of their last 20 games (+8.40 Units / 38% ROI)
• The Chicago Cubs have covered the Run Line in 9 of their last 12 games (+5.75 Units / 34% ROI)
• The Chicago Cubs have hit the 1st Five Innings (F5) Team Total Over in 7 of their last 9 away games (+4.70 Units / 41% ROI)

Padres Best Bets Today:

• The San Diego Padres have covered the Run Line in 31 of their last 50 games at home (+15.05 Units / 24% ROI)
• The San Diego Padres have hit the Moneyline in 16 of their last 20 games (+11.85 Units / 45% ROI)
• The San Diego Padres have covered the 1st Five Innings (F5) Run Line in 29 of their last 45 games at home (+11.05 Units / 21% ROI)
• The San Diego Padres have hit the 1st Five Innings (F5) Moneyline in 28 of their last 45 games at home (+10.10 Units / 15% ROI)
• The San Diego Padres have hit the Team Total Over in 31 of their last 50 games at home (+9.10 Units / 15% ROI)

Cubs Against the Spread (ATS) Record

Against the spread this season, the Cubs are 14-14 against the Run Line (-0.3 Units / -0.87% ROI).

• 17-11 when betting on the Moneyline for +2.4 Units / 6.25% ROI
• 17-10 when betting on the total runs Over for +6.15 Units / 19.94% ROI
• 10-17 when betting on the total runs Under for -8.75 Units / -28.36% ROI

Padres Against the Spread (ATS) Record

Against the spread this season, the Padres are 16-10 against the Run Line (+4.3 Units / 11.83% ROI).

• 18-9 when betting on the Moneyline for +8.35 Units / 24.27% ROI
• 11-14 when betting on the total runs Over for -4.15 Units / -14.07% ROI
• 14-11 when betting on the total runs Under for +1.9 Units / 6.34% ROI

Padres vs Cubs Home Run Prop Bets Today

Padres vs Cubs Total Hits Prop Bets Today

Padres vs Cubs Strikeout Prop Bets Today

Cubs Keys to the Game vs. the Padres

The Cubs are 3-10 (.231) when trailing entering the 8th inning this season — tied for 2nd best in MLB; League Avg: .104.

The Cubs are 53-27 (.662) after a loss since the 2025 season — best in MLB; League Avg: .481.

The Cubs are 44-9 (.830) when they’ve scored in the first inning since the 2025 season — best in MLB; League Avg: .637.

The Cubs are 59-7 (.894) when they’ve had 10 or more hits since the 2025 season — best in MLB; League Avg: .747.

Padres Keys to the Game vs. the Cubs

The Padres are 2-9 (.182) when trailing entering the 9th inning this season — 3rd best in MLB; League Avg: .050.

The Padres are 3-7 (.300) when trailing entering the 7th inning this season — tied for 3rd best in MLB; League Avg: .142.

The Padres are 9-4 (.692) at home this season — 3rd best in MLB; League Avg: .537.

The Padres are 12-1 (.923) when scoring 5 or more runs this season — tied for 3rd best in MLB; League Avg: .773.

Cubs Hitting Stats & Trends

Cubs hitters have an OBP of .376 (543 PA’s) with bases empty this season — best in MLB.

Cubs hitters have an OBP of .289 (564 PA’s) with two-strikes this season — best in MLB.

Cubs hitters have an OBP of .354 (1,116 PA’s) this season — 2nd best in MLB.

The Cubs are batting .286 against LHP this season — 2nd best in MLB.

Padres Hitting Stats & Trends

Padres hitters have struck out in just 19% of their PA’s against LHP since the 2025 season — 2nd best in MLB.

The Padres are batting .189 with two-strikes since the 2025 season — 2nd best in MLB.

Padres hitters have struck out in just 20% of their PA’s since the 2025 season — 3rd best in MLB.

Padres hitters have chased 30% of pitches out of the zone against RHP since the 2025 season — 5th highest in MLB.

Cubs Pitching Stats & Trends

Cubs pitchers have walked 7% of batters since the 2025 season — best in MLB.

Cubs pitchers have a strikeout rate of just 16% when facing the leadoff batter in the inning this season — 2nd lowest in MLB.

Opponents have a groundball rate of just 40% against Cubs pitchers since the 2025 season — 5th lowest in MLB.

Opponents have a groundball batting average of just .181 against Cubs pitchers with runners on base this season — best in MLB.

Padres Pitching Stats & Trends

Padres pitchers have a strikeout rate of 29% when facing the leadoff batter in the inning this season — best in MLB.

Opponents have a groundball rate of 47% against Padres pitchers this season — 3rd highest in MLB.

Opponents have a groundball rate of 50% against Padres pitchers over the past seven days (5 games) — tied for 2nd highest in MLB.

Opponents have a groundball rate of 47% against Padres pitchers this month (22 games) — 2nd highest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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