• The Cubs are -110 favorites vs the Padres
• Cubs vs Padres Over / Under today: 9 Runs
• Cubs / Padres TV Channel: MARQ | PDTV

The Chicago Cubs (-110) visit Petco Park to take on the San Diego Padres (-110) on April 29, 2026. First pitch is scheduled for 4:10 pm in San Diego, CA.

This season, the Cubs are 18-12 against the spread (ATS), while the Padres are 17-11 ATS.

Cubs vs Padres Starting Pitchers Today:

• Cubs starting pitcher: Jameson Taillon 1-1, 4.56 ERA
• Padres starting pitcher: Matt Waldron 0-1, 12.47 ERA

Cubs vs. Padres Odds, Run Line, Over/Under & Moneyline

Cubs vs Padres Prediction for Today’s Game

Based on recent trends the model predicts the Padres will win Wednesday‘s MLB game with 51.3% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Cubs vs Padres and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Cubs players for Wednesday‘s game, looking at profitable historical betting trends:

Best Cubs Player Prop Bets Today:

• Seiya Suzuki has hit the Home Runs Over in 5 of his last 8 games (+20.50 Units / 256% ROI)
• Seiya Suzuki has hit the Total Bases Over in 17 of his last 25 games (+11.35 Units / 37% ROI)
• Seiya Suzuki has hit the Runs Over in 16 of his last 25 games (+10.65 Units / 42% ROI)
• Carson Kelly has hit the Singles Over in 12 of his last 15 games (+10.30 Units / 67% ROI)
• Carson Kelly has hit the Hits Over in 13 of his last 15 games (+10.05 Units / 38% ROI)

And here are some favorite MLB player prop bets for Padres players for Wednesday‘s game, looking at profitable historical betting trends:

Best Padres Player Prop Best Bets Today:

• Xander Bogaerts has hit the Home Runs Over in 3 of his last 8 games at home (+17.50 Units / 219% ROI)
• Gavin Sheets has hit the Singles Under in 20 of his last 25 games at home (+12.15 Units / 32% ROI)
• Jake Cronenworth has hit the Total Bases Under in 18 of his last 25 games (+10.90 Units / 33% ROI)
• Jackson Merrill has hit the Runs Over in 16 of his last 25 games at home (+10.15 Units / 40% ROI)
• Jake Cronenworth has hit the Hits Under in 15 of his last 25 games (+8.75 Units / 33% ROI)

Cubs Best Bets Today:

• The Chicago Cubs have hit the Team Total Over in 21 of their last 30 games (+11.60 Units / 33% ROI)
• The Chicago Cubs have hit the Game Total Over in 16 of their last 23 games (+9.40 Units / 37% ROI)
• The Chicago Cubs have hit the Moneyline in 11 of their last 14 games (+8.75 Units / 53% ROI)
• The Chicago Cubs have covered the Run Line in 10 of their last 14 games (+6.15 Units / 33% ROI)
• The Chicago Cubs have hit the 1st Five Innings (F5) Team Total Over in 21 of their last 35 away games (+5.35 Units / 12% ROI)

Padres Best Bets Today:

• The San Diego Padres have covered the Run Line in 31 of their last 50 games at home (+14.40 Units / 23% ROI)
• The San Diego Padres have hit the Moneyline in 27 of their last 40 games (+12.95 Units / 25% ROI)
• The San Diego Padres have covered the 1st Five Innings (F5) Run Line in 32 of their last 50 games at home (+11.70 Units / 20% ROI)
• The San Diego Padres have hit the 1st Five Innings (F5) Moneyline in 30 of their last 50 games at home (+10.55 Units / 14% ROI)
• The San Diego Padres have hit the Team Total Over in 31 of their last 50 games at home (+8.80 Units / 15% ROI)

Cubs Against the Spread (ATS) Record

Against the spread this season, the Cubs are 15-15 against the Run Line (+0.1 Units / 0.27% ROI).

• 18-12 when betting on the Moneyline for +2.4 Units / 5.92% ROI
• 19-10 when betting on the total runs Over for +8.15 Units / 24.66% ROI
• 10-19 when betting on the total runs Under for -10.95 Units / -33.13% ROI

Padres Against the Spread (ATS) Record

Against the spread this season, the Padres are 17-11 against the Run Line (+3.65 Units / 9.22% ROI).

• 19-10 when betting on the Moneyline for +8.3 Units / 22.65% ROI
• 13-14 when betting on the total runs Over for -2.15 Units / -6.78% ROI
• 14-13 when betting on the total runs Under for -0.3 Units / -0.93% ROI

Padres vs Cubs Home Run Prop Bets Today

Padres vs Cubs Total Hits Prop Bets Today

Padres vs Cubs Strikeout Prop Bets Today

Cubs Keys to the Game vs. the Padres

The Cubs are 59-7 (.894) when they’ve had 10 or more hits since the 2025 season — best in MLB; League Avg: .746.

The Cubs are 14-0 (1.000) when leading entering the 8th inning this season — tied for best in MLB; League Avg: .894.

The Cubs are 14-0 (1.000) when leading entering the 7th inning this season — tied for best in MLB; League Avg: .855.

The Cubs are 44-9 (.830) when they’ve scored in the first inning since the 2025 season — best in MLB; League Avg: .637.

Padres Keys to the Game vs. the Cubs

The Padres are 2-10 (.167) when trailing entering the 9th inning this season — 3rd best in MLB; League Avg: .053.

The Padres are 14-1 (.933) when allowing 4 or fewer runs this season — 2nd best in MLB; League Avg: .727.

The Padres are 7-2 (.778) after a loss this season — tied for best in MLB; League Avg: .478.

The Padres are 3-8 (.273) when trailing entering the 7th inning this season — 5th best in MLB; League Avg: .145.

Cubs Hitting Stats & Trends

Cubs hitters have an OBP of .379 (428 PA’s) against LHP this season — best in MLB.

Cubs hitters have an OBP of .398 (266 PA’s) when leading off an inning this season — best in MLB.

Cubs hitters are slugging .440 against LHP since the 2025 season — 3rd best in MLB.

Cubs hitters have an OBP of .373 (585 PA’s) with bases empty this season — best in MLB.

Padres Hitting Stats & Trends

Padres hitters have struck out in just 19% of their PA’s against LHP since the 2025 season — tied for 2nd best in MLB.

Padres hitters have an OPS of just .628 (198 PA’s) against LHP this season — 5th lowest in MLB.

Padres hitters have a swing rate of 63% with two-strikes since the 2025 season — highest in MLB.

Padres hitters struck out just 278 times in 1,617 PA’s (17%) against LHP in the 2024 season — best in MLB; League Avg: 23%.

Cubs Pitching Stats & Trends

Cubs pitchers have walked 7% of batters since the 2025 season — best in MLB.

Cubs pitchers have walked 8% of batters this season — tied for 4th best in MLB.

Opponents have a miss rate of just 24% against Cubs pitchers since the 2025 season — tied for 4th lowest in MLB.

Opponents have a groundball rate of just 41% against Cubs pitchers since the 2025 season — 5th lowest in MLB.

Padres Pitching Stats & Trends

Opponents have a groundball rate of 47% against Padres pitchers this season — tied for highest in MLB.

Opponents have a miss rate of 27% against Padres pitchers this season — tied for 4th best in MLB.

Padres pitchers have an ERA of 8.13 (52.0 IP) over the past seven days (6 games) — highest in MLB.

Padres pitchers have a strikeout rate of just 15% over the past seven days (6 games) — lowest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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