Cubs vs Pirates Prediction, Odds & Player Prop Bets Today – MLB, May 25

Pittsburgh Pirates' Jack Suwinski hits a home run off Chicago Cubs starting pitcher Jameson Taillon during the first inning of a baseball game Tuesday, June 13, 2023, in Chicago.
(AP Photo/Charles Rex Arbogast)
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The Chicago Cubs (-130) visit PNC Park to take on the Pittsburgh Pirates (+105) on May 25, 2026. First pitch is scheduled for 1:35 pm in Pittsburgh, PA.

This season, the Cubs are 29-24 against the spread (ATS), while the Pirates are 27-25 ATS.

Cubs vs Pirates Starting Pitchers Today:

  • Cubs starting pitcher: Ben Brown 1-2, 2.12 ERA
  • Pirates starting pitcher: Carmen Mlodzinski 4-3, 3.99 ERA

Cubs vs. Pirates Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Cubs-1.5 +135O 8 -105-130
Pirates +1.5 -165U 8 -115+105

Cubs vs Pirates Prediction for Today’s Game

Based on recent trends the model predicts the Pirates will win Monday‘s MLB game with 53.2% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


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We’ve highlighted some favorite MLB player prop bets for Cubs players for Monday‘s game, looking at profitable historical betting trends:

Best Cubs Player Prop Bets Today:

  • Michael Conforto has hit the Runs Over in 13 of his last 20 away games (+13.25 Units / 66% ROI)
  • Dansby Swanson has hit the Singles Under in 20 of his last 25 away games (+12.25 Units / 31% ROI)
  • Nico Hoerner has hit the Hits Under in 13 of his last 15 away games (+8.25 Units / 24% ROI)
  • Dansby Swanson has hit the Hits Runs and RBIs Under in 14 of his last 20 games (+8.00 Units / 31% ROI)
  • Alex Bregman has hit the Total Bases Over in his last 6 away games (+7.65 Units / 112% ROI)

And here are some favorite MLB player prop bets for Pirates players for Monday‘s game, looking at profitable historical betting trends:

Best Pirates Player Prop Best Bets Today:

  • Konnor Griffin has hit the Total Bases Over in 17 of his last 20 games at home (+15.15 Units / 54% ROI)
  • Konnor Griffin has hit the Hits Over in 18 of his last 20 games at home (+14.15 Units / 38% ROI)
  • Konnor Griffin has hit the Runs Over in 15 of his last 25 games (+12.90 Units / 52% ROI)
  • Konnor Griffin has hit the Singles Over in 16 of his last 20 games at home (+12.15 Units / 56% ROI)
  • Spencer Horwitz has hit the Walks Over in 14 of his last 25 games at home (+11.90 Units / 48% ROI)
  • team high – away
  • team high – home

Cubs Against the Spread (ATS) Record

Against the spread this season, the Cubs are 21-32 against the Run Line (-10.85 Units / -17.83% ROI).

  • 29-24 when betting on the Moneyline for +0.35 Units / 0.49% ROI
  • 29-23 when betting on the total runs Over for +3.3 Units / 5.8% ROI
  • 23-29 when betting on the total runs Under for -7.75 Units / -13.43% ROI

Pirates Against the Spread (ATS) Record

Against the spread this season, the Pirates are 27-25 against the Run Line (+1.35 Units / 2.09% ROI).

  • 27-26 when betting on the Moneyline for -5.55 Units / -8.28% ROI
  • 27-24 when betting on the total runs Over for +1.5 Units / 2.6% ROI
  • 24-27 when betting on the total runs Under for -6.45 Units / -11.37% ROI

Pirates vs Cubs Home Run Prop Bets Today

Yes
Brandon Lowe +360
Oneil Cruz +475
Mike Busch +500
Ian Happ +525
Seiya Suzuki +525

Pirates vs Cubs Total Hits Prop Bets Today

Over Under
Nick Gonzales 0.5 -250 0.5 +180
Pete Crow-Armstrong 0.5 -235 0.5 +175
Bryan Reynolds 0.5 -225 0.5 +165
Spencer Horwitz 0.5 -220 0.5 +165
Seiya Suzuki 0.5 -200 0.5 +145

Pirates vs Cubs Strikeout Prop Bets Today

Over Under
Konnor Griffin 0.5 -275 0.5 +190
Mike Busch 0.5 -225 0.5 +165
Marcell Ozuna 0.5 -225 0.5 +165
Dansby Swanson 0.5 -185 0.5 +135
Michael Conforto 0.5 -185 0.5 +135

Cubs Keys to the Game vs. the Pirates

The Cubs are 8-1 (.889) when they’ve scored in the first inning this season — best in MLB; League Avg: .636.

The Cubs are 22-0 (1.000) when leading entering the 7th inning this season — tied for best in MLB; League Avg: .863.

The Cubs are 23-0 (1.000) when leading entering the 8th inning this season — tied for best in MLB; League Avg: .895.

The Cubs are 9-0 (1.000) when they’ve had 5 or more XBH this season — tied for best in MLB; League Avg: .791.

Pirates Keys to the Game vs. the Cubs

The Pirates are just 1-13 (.071) when allowing 10 or more hits this season — 2nd lowest in MLB; League Avg: .246.

The Pirates are 25-3 (.893) when allowing 4 or fewer runs this season — 2nd best in MLB; League Avg: .717.

The Pirates are just 2-23 (.080) when allowing 5 or more runs this season — lowest in MLB; League Avg: .207.

The Pirates are just 1-19 (.050) when trailing entering the 7th inning this season — 5th lowest in MLB; League Avg: .137.

Cubs hitters have drawn walks in 15% of their PA’s when leading off an inning this season — best in MLB.

Cubs hitters have drawn walks in 12% of their PA’s against RHP this season — best in MLB.

Cubs hitters have drawn walks in 13% of their PA’s when facing the starting pitcher for the 3rd time in a game this season — 3rd best in MLB.

Cubs hitters have put 40% of their swings in play on pitches 95 mph or greater this season — highest in MLB.

The Pirates are batting .316 when facing the starting pitcher for the 3rd time in a game this season — best in MLB.

The Pirates are batting .274 at home this season — best in MLB.

Pirates hitters have struck out in 28% of their PA’s against LHP this season — tied for 2nd highest in MLB.

Pirates hitters have 32 extra-base hits out of 131 total hits (just 24%) against LHP this season — lowest in MLB.

The Cubs pitchers have allowed an average Exit Velocity of 90.0 MPH this season (1,315 balls in play) — tied for 2nd highest in MLB

Cubs pitchers have allowed 73 home runs this season — 2nd most in MLB.

Opponents have a groundball batting average of just .204 against Cubs pitchers with runners on base this season — best in MLB.

Cubs pitchers have allowed an exit velocity of 95 MPH or greater 562 times this season — 4th most in MLB.

Opponents have a groundball batting average of just .211 against Pirates pitchers this season — best in MLB.

Pirates pitchers have walked 11% of batters when facing the leadoff batter in the inning this season — 4th highest in MLB.

Pirates pitchers have allowed 46 home runs this season — tied for 5th fewest in MLB.

Pirates pitchers have allowed a slugging percentage of just .365 this season — tied for 5th best in MLB.

More MLB Reading:


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Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.