• The Cubs are -120 favorites vs the Red Sox
• Cubs vs Red Sox Over / Under today: 7.5 Runs
• Cubs / Red Sox TV Channel: NESN | MARQ

The Chicago Cubs (-120) visit Tropicana Field to take on the Boston Red Sox (+100) on September 27, 2026. First pitch is scheduled for 3:05 pm in St. Petersburg, FL.

This season, the Cubs are 88-73 against the spread (ATS), while the Red Sox are 76-81 ATS.

Cubs vs Red Sox Starting Pitchers Today:

• Cubs starting pitcher: Undecided 0-0, 0.00 ERA
• Red Sox starting pitcher: Undecided 0-0, 0.00 ERA

Cubs vs. Red Sox Odds, Run Line, Over/Under & Moneyline

Cubs vs Red Sox Prediction for Today’s Game

Based on recent trends the model predicts the Cubs will win Sunday‘s MLB game with 51.6% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

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We’ve highlighted some favorite MLB player prop bets for Cubs players for Sunday‘s game, looking at profitable historical betting trends:

Best Cubs Player Prop Bets Today:

• Michael Conforto has hit the Home Runs Over in 4 of his last 10 away games (+15.30 Units / 153% ROI)
• Michael Conforto has hit the Runs Under in 21 of his last 25 games (+12.95 Units / 26% ROI)
• Ian Happ has hit the Hits Runs and RBIs Over in 17 of his last 25 games (+10.20 Units / 38% ROI)
• Michael Busch has hit the Walks Over in 10 of his last 15 away games (+9.75 Units / 65% ROI)
• Ian Happ has hit the Hits Over in 18 of his last 25 games (+8.95 Units / 24% ROI)

And here are some favorite MLB player prop bets for Red Sox players for Sunday‘s game, looking at profitable historical betting trends:

Best Red Sox Player Prop Best Bets Today:

• No trends found

Cubs Best Bets Today:

• The Chicago Cubs have covered the Run Line in 28 of their last 45 away games (+14.05 Units / 26% ROI)
• The Chicago Cubs have hit the Game Total Over in 28 of their last 45 games (+12.65 Units / 25% ROI)
• The Chicago Cubs have hit the Team Total Over in 29 of their last 45 away games (+10.85 Units / 20% ROI)
• The Chicago Cubs have hit the 1st Five Innings (F5) Moneyline in 17 of their last 30 games (+9.95 Units / 23% ROI)
• The Chicago Cubs have covered the 1st Five Innings (F5) Run Line in 19 of their last 30 games (+7.25 Units / 21% ROI)

Red Sox Best Bets Today:

• The Boston Red Sox have hit the 1st Five Innings (F5) Team Total Under in 25 of their last 35 games (+13.85 Units / 33% ROI)
• The Boston Red Sox have hit the Game Total Under in 17 of their last 20 games (+13.80 Units / 63% ROI)
• The Boston Red Sox have hit the Team Total Under in 13 of their last 16 games (+9.90 Units / 51% ROI)
• The Boston Red Sox have covered the 1st Five Innings (F5) Run Line in 26 of their last 45 games at home (+5.55 Units / 11% ROI)
• The Boston Red Sox have hit the Moneyline in 29 of their last 45 games at home (+3.90 Units / 6% ROI)

Cubs Against the Spread (ATS) Record

Against the spread this season, the Cubs are 75-84 against the Run Line (-5.1 Units / -2.73% ROI).

• 88-73 when betting on the Moneyline for -6.55 Units / -2.98% ROI
• 89-68 when betting on the total runs Over for +14.85 Units / 8.36% ROI
• 68-89 when betting on the total runs Under for -29.2 Units / -16.51% ROI

Red Sox Against the Spread (ATS) Record

Against the spread this season, the Red Sox are 76-81 against the Run Line (-3.55 Units / -1.79% ROI).

• 87-74 when betting on the Moneyline for -6.2 Units / -2.91% ROI
• 71-86 when betting on the total runs Over for -24.3 Units / -13.64% ROI
• 86-71 when betting on the total runs Under for +8.05 Units / 4.56% ROI

Cubs Keys to the Game vs. the Red Sox

The Cubs are 6-65 (.085) when trailing entering the 9th inning this season — 2nd best in MLB.

The Cubs are 30-35 (.462) when allowing 2 or more home runs this season — best in MLB.

The Cubs are 35-21 (.625) vs bottom 10 scoring offenses this season Today, they face the Red Sox (22nd in runs scored).

The Cubs are 48-6 (.889) when they’ve had 10 or more hits this season — 2nd best in MLB.

Red Sox Keys to the Game vs. the Cubs

The Red Sox are 63-5 (.926) when leading entering the 7th inning this season — 4th best in MLB.

The Red Sox are just 8-42 (.160) when allowing 5 or more runs this season — 4th lowest in MLB.

The Red Sox are 51-35 (.593) after a win this season — 4th best in MLB.

The Red Sox are 72-2 (.973) when leading entering the 8th inning this season — tied for 2nd best in MLB.

Cubs Hitting Stats & Trends

Cubs hitters are slugging .507 on breaking pitches against LHP this season — best in MLB.

Cubs hitters have an OPS of .547 (3,340 PA’s) with two-strikes this season — best in MLB.

Cubs hitters have an OBP of .368 (634 PA’s) when facing the starting pitcher for the 3rd time in a game this season — best in MLB.

Cubs hitters have an OBP of .348 (1,673 PA’s) against LHP this season — best in MLB.

Red Sox Hitting Stats & Trends

The Red Sox have a winning percentage of 57% on the road this season — 4th best in MLB.

The Red Sox are batting .173 on pitches out of the zone this season — 3rd best in MLB.

Red Sox hitters have a Hard-Hit Rate of just 36% against RHP this season — 3rd lowest in MLB.

Red Sox hitters are slugging .237 on pitches out of the zone this season — 4th best in MLB.

Cubs Pitching Stats & Trends

Opponents have a groundball batting average of just .214 against Cubs pitchers with runners on base this season — best in MLB.

Opponents have a groundball batting average of just .225 against Cubs pitchers this season — best in MLB.

In games when their opponents have scored three or more runs in an inning, the Cubs have still managed to win 33% of the time this season — tied for 2nd highest in MLB.

Cubs pitchers have picked-off 24 runners from first base this season — most in MLB.

Red Sox Pitching Stats & Trends

Red Sox pitchers have walked 8% of batters this season — 3rd best in MLB.

The Red Sox have allowed 0.96 runs per game (155/161) in late innings this season — best in MLB.

Red Sox pitchers have allowed a run just 24% of the time after their offense scores this season — lowest in MLB.

Red Sox pitchers have an ERA of 3.58 (729.0 IP) at home this season — 5th best in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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