• The Cubs are -110 favorites vs the White Sox
• Cubs vs White Sox Over / Under today: 8.5 Runs
• Cubs / White Sox TV Channel: MARQ | CHSN | WCIU

The Chicago Cubs (-110) visit Rate Field to take on the Chicago White Sox (-110) on May 16, 2026. First pitch is scheduled for 7:10 pm in Chicago, IL.

This season, the Cubs are 29-16 against the spread (ATS), while the White Sox are 24-19 ATS.

Cubs vs White Sox Starting Pitchers Today:

• Cubs starting pitcher: Jameson Taillon 2-2, 3.92 ERA
• White Sox starting pitcher: Davis Martin 5-1, 1.63 ERA

Cubs vs. White Sox Odds, Run Line, Over/Under & Moneyline

Cubs vs White Sox Prediction for Today’s Game

Based on recent trends the model predicts the White Sox will win Saturday‘s MLB game with 51.9% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Cubs vs White Sox and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Cubs players for Saturday‘s game, looking at profitable historical betting trends:

Best Cubs Player Prop Bets Today:

• Ian Happ has hit the Walks Over in 19 of his last 25 games (+15.05 Units / 55% ROI)
• Nico Hoerner has hit the Hits Under in 21 of his last 25 games (+13.20 Units / 24% ROI)
• Dansby Swanson has hit the Singles Under in 20 of his last 25 away games (+12.35 Units / 32% ROI)
• Alex Bregman has hit the RBIs Under in 21 of his last 25 games (+11.30 Units / 20% ROI)
• Ian Happ has hit the Runs Over in 16 of his last 25 games (+9.95 Units / 38% ROI)

And here are some favorite MLB player prop bets for White Sox players for Saturday‘s game, looking at profitable historical betting trends:

Best White Sox Player Prop Best Bets Today:

• Drew Romo has hit the Home Runs Over in 3 of his last 10 games (+22.00 Units / 220% ROI)
• Chase Meidroth has hit the Runs Over in 17 of his last 25 games (+17.35 Units / 69% ROI)
• Chase Meidroth has hit the Hits Over in 22 of his last 25 games (+17.25 Units / 36% ROI)
• Chase Meidroth has hit the Total Bases Over in 19 of his last 25 games (+14.60 Units / 40% ROI)
• Miguel Vargas has hit the Hits Runs and RBIs Over in 19 of his last 25 games (+12.60 Units / 45% ROI)

Cubs Best Bets Today:

• The Chicago Cubs have hit the Moneyline in 22 of their last 30 games (+14.75 Units / 38% ROI)
• The Chicago Cubs have hit the Team Total Over in 28 of their last 45 games (+9.60 Units / 19% ROI)
• The Chicago Cubs have hit the Game Total Over in 23 of their last 40 games (+5.65 Units / 13% ROI)
• The Chicago Cubs have hit the 1st Five Innings (F5) Team Total Under in 5 of their last 6 games (+3.70 Units / 47% ROI)
• The Chicago Cubs have hit the 1st Five Innings (F5) Moneyline in 7 of their last 14 games (+1.90 Units / 9% ROI)

White Sox Best Bets Today:

• The Chicago White Sox have hit the Team Total Over in 18 of their last 25 games (+10.35 Units / 37% ROI)
• The Chicago White Sox have hit the Moneyline in 16 of their last 25 games (+8.95 Units / 34% ROI)
• The Chicago White Sox have covered the Run Line in 17 of their last 25 games (+8.40 Units / 23% ROI)
• The Chicago White Sox have covered the 1st Five Innings (F5) Run Line in 27 of their last 45 games at home (+5.20 Units / 9% ROI)
• The Chicago White Sox have hit the 1st Five Innings (F5) Team Total Over in 6 of their last 7 games (+4.90 Units / 58% ROI)

Cubs Against the Spread (ATS) Record

Against the spread this season, the Cubs are 21-24 against the Run Line (-3.2 Units / -6.02% ROI).

• 29-16 when betting on the Moneyline for +9.4 Units / 15.16% ROI
• 25-19 when betting on the total runs Over for +4.5 Units / 9.11% ROI
• 19-25 when betting on the total runs Under for -8.45 Units / -16.98% ROI

White Sox Against the Spread (ATS) Record

Against the spread this season, the White Sox are 24-19 against the Run Line (-2.55 Units / -3.97% ROI).

• 22-22 when betting on the Moneyline for +4.45 Units / 9.78% ROI
• 25-19 when betting on the total runs Over for +4.25 Units / 8.84% ROI
• 19-25 when betting on the total runs Under for -8.65 Units / -17.76% ROI

White Sox vs Cubs Home Run Prop Bets Today

White Sox vs Cubs Total Hits Prop Bets Today

White Sox vs Cubs Strikeout Prop Bets Today

Cubs Keys to the Game vs. the White Sox

The Cubs are 19-3 (.864) vs the bottom 10 runs allowed teams this season Today, they face the White Sox (20th runs allowed).

The Cubs are 8-0 (1.000) when they’ve scored in the first inning this season — best in MLB; League Avg: .628.

The Cubs are 23-0 (1.000) when leading entering the 8th inning this season — tied for best in MLB; League Avg: .894.

The Cubs are 20-8 (.714) after a win this season — 2nd best in MLB; League Avg: .521.

White Sox Keys to the Game vs. the Cubs

The White Sox are just 3-11 (.214) vs top 10 scoring offenses this season Today, they face the Cubs (fifth in runs scored).

The White Sox are just 17-44 (.279) vs top 10 scoring offenses since the 2025 season Today, they face the Cubs (fifth in runs scored).

The White Sox are just 62-18 (.775) when leading entering the 7th inning since the 2025 season — lowest in MLB; League Avg: .873.

The White Sox are just 46-77 (.374) after a loss since the 2025 season — 2nd lowest in MLB; League Avg: .482.

Cubs Hitting Stats & Trends

The Cubs are batting .266 against LHP this season — tied for 3rd best in MLB.

Cubs hitters have come to the plate with runners in scoring position in 532 of their 1,773 plate appearances (30%) this season — 3rd highest in MLB.

Cubs hitters have an OPS of .775 (538 PA’s) against LHP this season — 4th best in MLB.

Cubs hitters have an OBP of .343 (1,773 PA’s) this season — best in MLB.

White Sox Hitting Stats & Trends

White Sox hitters have an OPS of .786 (476 PA’s) against LHP this season — best in MLB.

White Sox hitters are slugging .447 against LHP this season — 2nd best in MLB.

White Sox hitters are slugging .408 on the road this season — 5th best in MLB.

White Sox hitters have struck out in 24% of their PA’s this season — 4th highest in MLB.

Cubs Pitching Stats & Trends

Cubs pitchers have walked 8% of batters this season — 4th best in MLB.

Opponents have a groundball batting average of just .187 against Cubs pitchers with runners on base this season — best in MLB.

Cubs pitchers have an ERA of 3.04 (213.0 IP) at home this season — 5th best in MLB.

Cubs pitchers have allowed 57 home runs this season — 4th most in MLB.

White Sox Pitching Stats & Trends

White Sox pitchers have walked 12% of batters when facing the leadoff batter in the inning this season — highest in MLB.

Opponents have a miss rate of just 23% against White Sox pitchers this season — 4th lowest in MLB.

White Sox pitchers have a strikeout rate of just 13% when going through the lineup the third time in a game this season — lowest in MLB.

White Sox pitchers have a strikeout rate of just 39% with two-strikes this season — 5th lowest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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