• The Diamondbacks are -110 favorites vs the Astros
• Diamondbacks vs Astros Over / Under today: 8 Runs
• Diamondbacks / Astros TV Channel: DBTV | SCHN

The Arizona Diamondbacks (-110) visit Daikin Park to take on the Houston Astros (-110) on September 6, 2026. First pitch is scheduled for 2:10 pm in Houston, TX.

This season, the Diamondbacks are 75-68 against the spread (ATS), while the Astros are 73-70 ATS.

Diamondbacks vs Astros Starting Pitchers Today:

• Diamondbacks starting pitcher: Eduardo Rodriguez 14-5, 2.58 ERA
• Astros starting pitcher: Peter Lambert 8-7, 3.66 ERA

Diamondbacks vs. Astros Odds, Run Line, Over/Under & Moneyline

Diamondbacks vs Astros Prediction for Today’s Game

Based on recent trends the model predicts the Astros will win Sunday‘s MLB game with 52.1% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

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We’ve highlighted some favorite MLB player prop bets for Diamondbacks players for Sunday‘s game, looking at profitable historical betting trends:

Best Diamondbacks Player Prop Bets Today:

• Gabriel Moreno has hit the Home Runs Over in 4 of his last 9 away games (+26.10 Units / 290% ROI)
• Gabriel Moreno has hit the Total Bases Over in 18 of his last 25 games (+16.15 Units / 64% ROI)
• Corbin Carroll has hit the Walks Over in 15 of his last 25 away games (+13.05 Units / 52% ROI)
• Eduardo Rodriguez has hit the Earned Runs Under in 19 of his last 25 games (+12.80 Units / 45% ROI)
• Geraldo Perdomo has hit the Runs Under in 17 of his last 20 games (+12.10 Units / 35% ROI)

And here are some favorite MLB player prop bets for Astros players for Sunday‘s game, looking at profitable historical betting trends:

Best Astros Player Prop Best Bets Today:

• Jeremy Pena has hit the Hits Under in 13 of his last 15 games at home (+13.00 Units / 43% ROI)
• Nick Allen has hit the Home Runs Over in 1 of his last 4 games at home (+12.00 Units / 300% ROI)
• Daulton Varsho has hit the Hits Runs and RBIs Under in 19 of his last 25 games at home (+11.35 Units / 35% ROI)
• Christian Walker has hit the Runs Under in 17 of his last 20 games (+11.25 Units / 32% ROI)
• Daulton Varsho has hit the RBIs Under in 21 of his last 25 games at home (+10.60 Units / 18% ROI)

Diamondbacks Best Bets Today:

• The Arizona Diamondbacks have hit the 1st Five Innings (F5) Team Total Under in 30 of their last 45 away games (+13.70 Units / 25% ROI)
• The Arizona Diamondbacks have hit the Game Total Under in 29 of their last 45 away games (+11.65 Units / 24% ROI)
• The Arizona Diamondbacks have hit the Moneyline in 29 of their last 50 games (+10.40 Units / 18% ROI)
• The Arizona Diamondbacks have hit the Team Total Under in their last 6 games (+6.15 Units / 83% ROI)
• The Arizona Diamondbacks have covered the Run Line in 20 of their last 35 games (+2.20 Units / 5% ROI)

Astros Best Bets Today:

• The Houston Astros have covered the Run Line in 28 of their last 50 games (+9.25 Units / 15% ROI)
• The Houston Astros have hit the 1st Five Innings (F5) Team Total Over in 16 of their last 24 games at home (+7.80 Units / 29% ROI)
• The Houston Astros have hit the Team Total Under in 10 of their last 13 games at home (+6.80 Units / 45% ROI)
• The Houston Astros have hit the Game Total Under in 10 of their last 13 games at home (+6.75 Units / 47% ROI)
• The Houston Astros have hit the 1st Five Innings (F5) Moneyline in 14 of their last 24 games at home (+5.45 Units / 16% ROI)

Diamondbacks Against the Spread (ATS) Record

Against the spread this season, the Diamondbacks are 76-63 against the Run Line (+1.55 Units / 0.81% ROI).

• 75-68 when betting on the Moneyline for +7.6 Units / 4.55% ROI
• 61-76 when betting on the total runs Over for -22.7 Units / -14.38% ROI
• 76-61 when betting on the total runs Under for +9.35 Units / 5.96% ROI

Astros Against the Spread (ATS) Record

Against the spread this season, the Astros are 73-70 against the Run Line (-1.05 Units / -0.55% ROI).

• 73-70 when betting on the Moneyline for -6.65 Units / -3.87% ROI
• 71-63 when betting on the total runs Over for +0.7 Units / 0.44% ROI
• 63-71 when betting on the total runs Under for -15 Units / -9.6% ROI

Diamondbacks Keys to the Game vs. the Astros

The Diamondbacks are 64-0 (1.000) when leading entering the 9th inning this season — tied for best in MLB.

The Diamondbacks are 11-51 (.177) when trailing entering the 7th inning this season — 5th best in MLB.

The Diamondbacks were just 67-7 (.905) when leading entering the 9th inning in the 2025 season — 2nd lowest in MLB; League Avg: .956.

The Diamondbacks are 9-124 (.068) when trailing entering the 9th inning since the 2025 season — 3rd best in MLB.

Astros Keys to the Game vs. the Diamondbacks

The Astros are 12-5 (.706) when tied entering the 8th inning this season — 2nd best in MLB.

The Astros are 54-4 (.931) when leading entering the 7th inning this season — tied for 2nd best in MLB.

The Astros are 63-0 (1.000) when leading entering the 9th inning this season — tied for best in MLB.

The Astros are 23-14 (.622) when tied entering the 7th inning since the 2025 season — 3rd best in MLB.

Diamondbacks Hitting Stats & Trends

The Diamondbacks are batting .276 against LHP this season — best in MLB.

Diamondbacks hitters have struck out in just 18% of their PA’s against LHP this season — best in MLB.

Diamondbacks hitters have put 40% of their swings in play against LHP this season — tied for highest in MLB.

Diamondbacks hitters are slugging .438 against LHP this season — 3rd best in MLB.

Astros Hitting Stats & Trends

29% of Astros hitters strikeouts have come on 95+ MPH fastballs this season — tied for highest in MLB.

Astros hitters have drawn walks in 13% of their PA’s with runners in scoring position this season — best in MLB.

Astros hitters have an OBP of just .237 (2,826 PA’s) with two-strikes this season — tied for 3rd lowest in MLB.

Astros hitters have 42 extra-base hits out of 159 total hits (just 26%) when facing the starting pitcher for the 3rd time in a game this season — lowest in MLB.

Diamondbacks Pitching Stats & Trends

Diamondbacks pitchers have a strikeout rate of just 38% with two-strikes this season — 3rd lowest in MLB.

Diamondbacks pitchers have a strikeout rate of just 18% this season — 2nd lowest in MLB.

Diamondbacks pitchers have walked 8% of batters this season — 4th best in MLB.

The Diamondbacks pitchers have allowed their opponents to score first in 56% of their games on the road this season — 2nd highest in MLB.

Astros Pitching Stats & Trends

Astros pitchers have walked 11% of batters this season — highest in MLB.

Opponents have a groundball rate of just 39% against Astros pitchers this season — 2nd lowest in MLB.

Astros pitchers have walked 11% of batters when facing the leadoff batter in the inning this season — highest in MLB.

The Astros have allowed 3.08 runs per game (441/143) in the first 5 innings this season — 3rd highest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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