• The Cardinals are -135 favorites vs the Diamondbacks
• Diamondbacks vs Cardinals Over / Under today: 9 Runs
• Diamondbacks / Cardinals TV Channel: CATV | DBTV

The Arizona Diamondbacks (+110) visit Busch Stadium to take on the St. Louis Cardinals (-135) on June 25, 2026. First pitch is scheduled for 7:45 pm in St. Louis, MO.

This season, the Diamondbacks are 41-39 against the spread (ATS), while the Cardinals are 46-30 ATS.

Diamondbacks vs Cardinals Starting Pitchers Today:

• Diamondbacks starting pitcher: Zac Gallen 3-6, 6.13 ERA
• Cardinals starting pitcher: Michael McGreevy 3-6, 3.39 ERA

Diamondbacks vs. Cardinals Odds, Run Line, Over/Under & Moneyline

Diamondbacks vs Cardinals Prediction for Today’s Game

Based on recent trends the model predicts the Cardinals will win Thursday‘s MLB game with 54.6% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

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We’ve highlighted some favorite MLB player prop bets for Diamondbacks players for Thursday‘s game, looking at profitable historical betting trends:

Best Diamondbacks Player Prop Bets Today:

• Tommy Troy has hit the Home Runs Over in 2 of his last 4 away games (+18.00 Units / 450% ROI)
• Corbin Carroll has hit the RBIs Under in 21 of his last 25 away games (+14.00 Units / 26% ROI)
• Zac Gallen has hit the Strikeouts Under in 13 of his last 15 away games (+11.65 Units / 63% ROI)
• Gabriel Moreno has hit the Hits Runs and RBIs Over in 13 of his last 15 away games (+11.20 Units / 60% ROI)
• Ketel Marte has hit the Runs Under in 18 of his last 25 away games (+11.20 Units / 37% ROI)

And here are some favorite MLB player prop bets for Cardinals players for Thursday‘s game, looking at profitable historical betting trends:

Best Cardinals Player Prop Best Bets Today:

• Alec Burleson has hit the RBIs Over in 16 of his last 25 games at home (+16.55 Units / 66% ROI)
• Alec Burleson has hit the Singles Over in 16 of his last 20 games at home (+10.85 Units / 41% ROI)
• Jordan Walker has hit the Runs Under in 16 of his last 20 games at home (+10.45 Units / 36% ROI)
• Ivan Herrera has hit the Total Bases Under in 16 of his last 20 games (+10.30 Units / 33% ROI)
• Ivan Herrera has hit the Walks Over in 10 of his last 15 games (+9.90 Units / 66% ROI)

Diamondbacks Best Bets Today:

• The Arizona Diamondbacks have hit the 1st Five Innings (F5) Team Total Under in 37 of their last 50 games (+23.25 Units / 39% ROI)
• The Arizona Diamondbacks have hit the Game Total Under in 29 of their last 45 games (+13.80 Units / 28% ROI)
• The Arizona Diamondbacks have hit the Team Total Over in 31 of their last 50 away games (+10.10 Units / 17% ROI)
• The Arizona Diamondbacks have covered the Run Line in 4 of their last 6 away games (+3.95 Units / 56% ROI)
• The Arizona Diamondbacks have covered the 1st Five Innings (F5) Run Line in 5 of their last 7 games (+2.80 Units / 32% ROI)

Cardinals Best Bets Today:

• The St. Louis Cardinals have hit the 1st Five Innings (F5) Team Total Over in 16 of their last 22 games (+10.30 Units / 40% ROI)
• The St. Louis Cardinals have covered the 1st Five Innings (F5) Run Line in 31 of their last 50 games (+9.90 Units / 17% ROI)
• The St. Louis Cardinals have covered the Run Line in 30 of their last 50 games (+7.85 Units / 11% ROI)
• The St. Louis Cardinals have hit the 1st Five Innings (F5) Moneyline in 25 of their last 50 games (+7.80 Units / 14% ROI)
• The St. Louis Cardinals have hit the Game Total Under in 25 of their last 45 games (+6.30 Units / 13% ROI)

Diamondbacks Against the Spread (ATS) Record

Against the spread this season, the Diamondbacks are 45-33 against the Run Line (+6.75 Units / 6.29% ROI).

• 41-39 when betting on the Moneyline for -0.05 Units / -0.05% ROI
• 34-42 when betting on the total runs Over for -11.95 Units / -13.54% ROI
• 42-34 when betting on the total runs Under for +5 Units / 5.69% ROI

Cardinals Against the Spread (ATS) Record

Against the spread this season, the Cardinals are 46-30 against the Run Line (+8 Units / 7.22% ROI).

• 42-36 when betting on the Moneyline for +9.8 Units / 11.73% ROI
• 35-39 when betting on the total runs Over for -7.6 Units / -8.9% ROI
• 39-35 when betting on the total runs Under for +0.25 Units / 0.29% ROI

Cardinals vs Diamondbacks Home Run Prop Bets Today

Cardinals vs Diamondbacks Total Hits Prop Bets Today

Cardinals vs Diamondbacks Strikeout Prop Bets Today

Diamondbacks Keys to the Game vs. the Cardinals

The Diamondbacks are 35-0 (1.000) when leading entering the 9th inning this season — tied for best in MLB; League Avg: .942.

The Diamondbacks are just 88-23 (.793) when leading entering the 7th inning since the 2025 season — 2nd lowest in MLB; League Avg: .870.

The Diamondbacks are just 99-16 (.861) when leading entering the 8th inning since the 2025 season — 2nd lowest in MLB; League Avg: .904.

The Diamondbacks were just 67-7 (.905) when leading entering the 9th inning in the 2025 season — 2nd lowest in MLB; League Avg: .956.

Cardinals Keys to the Game vs. the Diamondbacks

The Cardinals are just 10-96 (.094) when trailing entering the 7th inning since the 2025 season — 5th lowest in MLB; League Avg: .130.

The Cardinals were 18-9 (.667) when tied entering the 7th inning in the 2024 season — tied for 3rd best in MLB; League Avg: .498.

The Cardinals were 69-1 (.986) when leading entering the 9th inning in the 2024 season — tied for 2nd best in MLB; League Avg: .949.

The Cardinals were just 7-11 (.389) when tied entering the 8th inning in the 2025 season — tied for 5th lowest in MLB; League Avg: .500.

Diamondbacks Hitting Stats & Trends

Diamondbacks hitters have struck out in just 16% of their PA’s against LHP this season — best in MLB.

Diamondbacks hitters have put 42% of their swings in play against LHP this season — highest in MLB.

The Diamondbacks are batting .270 against LHP this season — 3rd best in MLB.

Diamondbacks hitters have a swing rate of just 26% on the first pitch of at-bats this season — lowest in MLB.

Cardinals Hitting Stats & Trends

Cardinals hitters have struck out in just 17% of their PA’s against LHP this season — 2nd best in MLB.

Cardinals hitters have 112 extra-base hits out of 375 total hits (just 30%) against starting pitchers this season — lowest in MLB.

The Cardinals are batting .181 with two-strikes this season — 3rd best in MLB.

The Cardinals are batting .177 on pitches out of the zone this season — 5th best in MLB.

Diamondbacks Pitching Stats & Trends

Diamondbacks pitchers have a strikeout rate of just 18% this season — 2nd lowest in MLB.

Opponents have a miss rate of just 23% against Diamondbacks pitchers this season — 3rd lowest in MLB.

Diamondbacks pitchers have a strikeout rate of just 39% with two-strikes this season — 4th lowest in MLB.

Diamondbacks pitchers have a strikeout rate of just 17% in the first 5 innings this season — 2nd lowest in MLB.

Cardinals Pitching Stats & Trends

Cardinals pitchers have allowed an average Exit Velocity of 90.1 MPH (2,059 batted balls) this season — highest in MLB.

Opponents have a miss rate of just 22% against Cardinals pitchers this season — 2nd lowest in MLB.

Cardinals pitchers have a strikeout rate of just 20% this season — tied for 3rd lowest in MLB.

Opponents have a groundball rate of 46% against Cardinals pitchers this season — tied for highest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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