• The Cubs are -140 favorites vs the Diamondbacks
• Diamondbacks vs Cubs Over / Under today: 7 Runs
• Diamondbacks / Cubs TV Channel: MARQ | DBTV

The Arizona Diamondbacks (+115) visit Wrigley Field to take on the Chicago Cubs (-140) on May 1, 2026. First pitch is scheduled for 2:20 pm in Chicago, IL.

This season, the Diamondbacks are 16-14 against the spread (ATS), while the Cubs are 15-16 ATS.

Diamondbacks vs Cubs Starting Pitchers Today:

• Diamondbacks starting pitcher: Zac Gallen 1-1, 3.22 ERA
• Cubs starting pitcher: Colin Rea 3-1, 4.61 ERA

Diamondbacks vs. Cubs Odds, Run Line, Over/Under & Moneyline

Diamondbacks vs Cubs Prediction for Today’s Game

Based on recent trends the model predicts the Cubs will win Friday‘s MLB game with 53.4% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Diamondbacks vs Cubs and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Diamondbacks players for Friday‘s game, looking at profitable historical betting trends:

Best Diamondbacks Player Prop Bets Today:

• Ildemaro Vargas has hit the Home Runs Over in 3 of his last 8 games (+19.60 Units / 245% ROI)
• Ildemaro Vargas has hit the Hits Over in 18 of his last 20 games (+16.25 Units / 44% ROI)
• Alek Thomas has hit the Singles Under in 20 of his last 25 games (+13.10 Units / 34% ROI)
• Ildemaro Vargas has hit the Total Bases Over in 14 of his last 20 games (+11.20 Units / 45% ROI)
• Ildemaro Vargas has hit the Runs Over in 8 of his last 10 away games (+10.80 Units / 108% ROI)

And here are some favorite MLB player prop bets for Cubs players for Friday‘s game, looking at profitable historical betting trends:

Best Cubs Player Prop Best Bets Today:

• Nico Hoerner has hit the Home Runs Over in 2 of his last 7 games at home (+12.00 Units / 171% ROI)
• Moises Ballesteros has hit the Hits Runs and RBIs Over in 15 of his last 20 games at home (+11.00 Units / 48% ROI)
• Carson Kelly has hit the Singles Over in 12 of his last 15 games (+10.30 Units / 67% ROI)
• Carson Kelly has hit the Hits Over in 13 of his last 15 games (+10.05 Units / 38% ROI)
• Alex Bregman has hit the RBIs Under in 13 of his last 15 games (+8.65 Units / 25% ROI)

Diamondbacks Best Bets Today:

• The Arizona Diamondbacks have hit the Team Total Over in 28 of their last 40 away games (+14.85 Units / 32% ROI)
• The Arizona Diamondbacks have hit the 1st Five Innings (F5) Team Total Over in 28 of their last 40 away games (+14.55 Units / 30% ROI)
• The Arizona Diamondbacks have hit the Game Total Over in 29 of their last 50 games (+9.35 Units / 17% ROI)
• The Arizona Diamondbacks have covered the Run Line in 27 of their last 40 away games (+6.90 Units / 11% ROI)
• The Arizona Diamondbacks have hit the 1st Five Innings (F5) Moneyline in 15 of their last 30 games (+5.20 Units / 15% ROI)

Cubs Best Bets Today:

• The Chicago Cubs have hit the Team Total Over in 24 of their last 35 games (+12.60 Units / 31% ROI)
• The Chicago Cubs have covered the 1st Five Innings (F5) Run Line in 26 of their last 40 games at home (+11.45 Units / 24% ROI)
• The Chicago Cubs have hit the Game Total Over in 17 of their last 23 games (+11.40 Units / 44% ROI)
• The Chicago Cubs have hit the 1st Five Innings (F5) Moneyline in 30 of their last 50 games at home (+11.30 Units / 15% ROI)
• The Chicago Cubs have covered the Run Line in 16 of their last 24 games at home (+10.25 Units / 36% ROI)

Diamondbacks Against the Spread (ATS) Record

Against the spread this season, the Diamondbacks are 20-10 against the Run Line (+6.35 Units / 14.53% ROI).

• 16-14 when betting on the Moneyline for +3.25 Units / 9.77% ROI
• 18-11 when betting on the total runs Over for +6.15 Units / 18.64% ROI
• 11-18 when betting on the total runs Under for -8.65 Units / -26.17% ROI

Cubs Against the Spread (ATS) Record

Against the spread this season, the Cubs are 15-16 against the Run Line (-0.9 Units / -2.4% ROI).

• 19-12 when betting on the Moneyline for +3.4 Units / 8.17% ROI
• 20-10 when betting on the total runs Over for +9.15 Units / 26.72% ROI
• 10-20 when betting on the total runs Under for -11.95 Units / -35.1% ROI

Cubs vs Diamondbacks Home Run Prop Bets Today

Cubs vs Diamondbacks Total Hits Prop Bets Today

Cubs vs Diamondbacks Strikeout Prop Bets Today

Diamondbacks Keys to the Game vs. the Cubs

The Diamondbacks are just 71-21 (.772) when leading entering the 7th inning since the 2025 season — 2nd lowest in MLB; League Avg: .871.

The Diamondbacks are just 79-15 (.840) when leading entering the 8th inning since the 2025 season — 2nd lowest in MLB; League Avg: .906.

The Diamondbacks are 4-7 (.364) when trailing entering the 7th inning this season — best in MLB; League Avg: .150.

The Diamondbacks are just 10-4 (.714) when leading entering the 7th inning this season — 4th lowest in MLB; League Avg: .850.

Cubs Keys to the Game vs. the Diamondbacks

The Cubs are 44-9 (.830) when they’ve scored in the first inning since the 2025 season — best in MLB; League Avg: .637.

The Cubs are 59-7 (.894) when they’ve had 10 or more hits since the 2025 season — best in MLB; League Avg: .745.

The Cubs are 53-23 (.697) vs the bottom 10 runs allowed teams since the 2025 season Today, they face the Diamondbacks (27th runs allowed).

The Cubs are 15-0 (1.000) when leading entering the 7th inning this season — tied for best in MLB; League Avg: .850.

Diamondbacks Hitting Stats & Trends

The Diamondbacks are batting .292 against LHP this season — best in MLB.

Diamondbacks hitters have a swing rate of just 23% on the first pitch of at-bats this season — lowest in MLB.

Diamondbacks hitters have an OBP of just .292 (773 PA’s) against RHP this season — tied for 2nd lowest in MLB.

The Diamondbacks are batting .365 in lefty-lefty matchups this season — best in MLB.

Cubs Hitting Stats & Trends

Cubs hitters have an OPS of .846 (432 PA’s) against LHP this season — best in MLB.

Cubs hitters have an OBP of .380 (432 PA’s) against LHP this season — best in MLB.

Cubs hitters have an OBP of .375 (605 PA’s) with bases empty this season — best in MLB.

Cubs hitters have an OPS of .846 (605 PA’s) with bases empty this season — best in MLB.

Diamondbacks Pitching Stats & Trends

Diamondbacks pitchers have a strikeout rate of just 19% with runners in scoring position this season — 2nd lowest in MLB.

Diamondbacks pitchers have a strikeout rate of just 19% this season — tied for 2nd lowest in MLB.

Opponents have a miss rate of just 23% against Diamondbacks pitchers this season — 5th lowest in MLB.

Opponents have a miss rate of just 24% against Diamondbacks pitchers since the 2025 season — tied for 4th lowest in MLB.

Cubs Pitching Stats & Trends

Cubs pitchers have walked 7% of batters since the 2025 season — best in MLB.

Opponents have a miss rate of just 24% against Cubs pitchers since the 2025 season — tied for 4th lowest in MLB.

Cubs pitchers have walked 8% of batters this season — 4th best in MLB.

Opponents have a groundball rate of just 41% against Cubs pitchers since the 2025 season — tied for 5th lowest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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