• The Cubs are -170 favorites vs the Diamondbacks
• Diamondbacks vs Cubs Over / Under today: 7.5 Runs
• Diamondbacks / Cubs TV Channel: MARQ | DBTV

The Arizona Diamondbacks (+140) visit Wrigley Field to take on the Chicago Cubs (-170) on May 2, 2026. First pitch is scheduled for 2:20 pm in Chicago, IL.

This season, the Diamondbacks are 16-15 against the spread (ATS), while the Cubs are 15-17 ATS.

Diamondbacks vs Cubs Starting Pitchers Today:

• Diamondbacks starting pitcher: Ryne Nelson 1-2, 7.62 ERA
• Cubs starting pitcher: Shota Imanaga 2-2, 3.15 ERA

Diamondbacks vs. Cubs Odds, Run Line, Over/Under & Moneyline

Diamondbacks vs Cubs Prediction for Today’s Game

Based on recent trends the model predicts the Cubs will win Saturday‘s MLB game with 57.8% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Diamondbacks vs Cubs and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Diamondbacks players for Saturday‘s game, looking at profitable historical betting trends:

Best Diamondbacks Player Prop Bets Today:

• Ildemaro Vargas has hit the Hits Over in 23 of his last 25 games (+21.25 Units / 47% ROI)
• Ildemaro Vargas has hit the Home Runs Over in 3 of his last 9 games (+18.60 Units / 207% ROI)
• Ildemaro Vargas has hit the Total Bases Over in 18 of his last 25 games (+14.85 Units / 47% ROI)
• Jose Fernandez has hit the Singles Over in 17 of his last 20 games (+14.73 Units / 68% ROI)
• Ildemaro Vargas has hit the Hits Runs and RBIs Over in 12 of his last 15 away games (+9.70 Units / 60% ROI)

And here are some favorite MLB player prop bets for Cubs players for Saturday‘s game, looking at profitable historical betting trends:

Best Cubs Player Prop Best Bets Today:

• Seiya Suzuki has hit the Home Runs Over in 5 of his last 9 games (+19.50 Units / 217% ROI)
• Moises Ballesteros has hit the Hits Runs and RBIs Over in 15 of his last 20 games at home (+11.00 Units / 48% ROI)
• Seiya Suzuki has hit the Total Bases Over in 15 of his last 20 games at home (+10.75 Units / 41% ROI)
• Carson Kelly has hit the Singles Over in 12 of his last 15 games (+10.35 Units / 67% ROI)
• Ian Happ has hit the Walks Over in 12 of his last 15 games at home (+10.20 Units / 65% ROI)

Diamondbacks Best Bets Today:

• The Arizona Diamondbacks have hit the Team Total Over in 28 of their last 40 away games (+15.00 Units / 33% ROI)
• The Arizona Diamondbacks have hit the 1st Five Innings (F5) Team Total Over in 19 of their last 25 away games (+13.00 Units / 44% ROI)
• The Arizona Diamondbacks have hit the Game Total Over in 30 of their last 50 games (+11.45 Units / 21% ROI)
• The Arizona Diamondbacks have covered the Run Line in 21 of their last 30 games (+8.35 Units / 19% ROI)
• The Arizona Diamondbacks have hit the 1st Five Innings (F5) Moneyline in 15 of their last 30 games (+5.20 Units / 15% ROI)

Cubs Best Bets Today:

• The Chicago Cubs have hit the Team Total Over in 25 of their last 35 games (+14.75 Units / 37% ROI)
• The Chicago Cubs have hit the Game Total Over in 18 of their last 24 games (+12.40 Units / 46% ROI)
• The Chicago Cubs have covered the 1st Five Innings (F5) Run Line in 26 of their last 40 games at home (+11.45 Units / 24% ROI)
• The Chicago Cubs have hit the 1st Five Innings (F5) Moneyline in 30 of their last 50 games at home (+11.30 Units / 14% ROI)
• The Chicago Cubs have hit the Moneyline in 13 of their last 16 games (+10.75 Units / 57% ROI)

Diamondbacks Against the Spread (ATS) Record

Against the spread this season, the Diamondbacks are 21-10 against the Run Line (+7.35 Units / 16.14% ROI).

• 16-15 when betting on the Moneyline for +2.25 Units / 6.57% ROI
• 19-11 when betting on the total runs Over for +7.15 Units / 20.97% ROI
• 11-19 when betting on the total runs Under for -9.75 Units / -28.55% ROI

Cubs Against the Spread (ATS) Record

Against the spread this season, the Cubs are 15-17 against the Run Line (-1.9 Units / -4.94% ROI).

• 20-12 when betting on the Moneyline for +4.4 Units / 10.22% ROI
• 21-10 when betting on the total runs Over for +10.15 Units / 28.71% ROI
• 10-21 when betting on the total runs Under for -13.05 Units / -37.13% ROI

Cubs vs Diamondbacks Home Run Prop Bets Today

Cubs vs Diamondbacks Total Hits Prop Bets Today

Cubs vs Diamondbacks Strikeout Prop Bets Today

Diamondbacks Keys to the Game vs. the Cubs

The Diamondbacks are just 71-21 (.772) when leading entering the 7th inning since the 2025 season — 2nd lowest in MLB; League Avg: .871.

The Diamondbacks are just 79-15 (.840) when leading entering the 8th inning since the 2025 season — tied for 2nd lowest in MLB; League Avg: .906.

The Diamondbacks are just 0-12 (.000) when trailing entering the 9th inning this season — tied for lowest in MLB; League Avg: .057.

The Diamondbacks are 4-8 (.333) when trailing entering the 7th inning this season — best in MLB; League Avg: .148.

Cubs Keys to the Game vs. the Diamondbacks

The Cubs are 59-7 (.894) when they’ve had 10 or more hits since the 2025 season — best in MLB; League Avg: .745.

The Cubs are 54-23 (.701) vs the bottom 10 runs allowed teams since the 2025 season Today, they face the Diamondbacks (28th runs allowed).

The Cubs are 45-9 (.833) when they’ve scored in the first inning since the 2025 season — best in MLB; League Avg: .636.

The Cubs are 16-0 (1.000) when leading entering the 7th inning this season — tied for best in MLB; League Avg: .852.

Diamondbacks Hitting Stats & Trends

Diamondbacks hitters have an OBP of just .290 (808 PA’s) against RHP this season — 2nd lowest in MLB.

Diamondbacks hitters have a swing rate of just 23% on the first pitch of at-bats this season — lowest in MLB.

The Diamondbacks are batting .297 against LHP this season — best in MLB.

Diamondbacks hitters have struck out in just 19% of their PA’s against LHP since the 2025 season — 3rd best in MLB.

Cubs Hitting Stats & Trends

Cubs hitters have an OPS of .833 (438 PA’s) against LHP this season — best in MLB.

The Cubs are batting .280 against LHP this season — 2nd best in MLB.

Cubs hitters have an OPS of .836 (623 PA’s) with bases empty this season — best in MLB.

Cubs hitters have an OBP of .374 (438 PA’s) against LHP this season — best in MLB.

Diamondbacks Pitching Stats & Trends

Diamondbacks pitchers have a strikeout rate of just 19% this season — 2nd lowest in MLB.

Diamondbacks pitchers have walked 6% of batters when facing the leadoff batter in the inning this season — 3rd best in MLB.

Opponents have a miss rate of just 23% against Diamondbacks pitchers this season — 5th lowest in MLB.

Diamondbacks pitchers have a strikeout rate of just 19% versus the bottom of the order this season — 2nd lowest in MLB.

Cubs Pitching Stats & Trends

Cubs pitchers have walked 7% of batters since the 2025 season — best in MLB.

Opponents have a miss rate of just 24% against Cubs pitchers since the 2025 season — tied for 4th lowest in MLB.

Cubs pitchers have walked 8% of batters this season — 4th best in MLB.

Cubs pitchers have an ERA of 5.20 (128.0 IP) on the road this season — 5th highest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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