• The Cubs are -160 favorites vs the Diamondbacks
• Diamondbacks vs Cubs Over / Under today: 11.5 Runs
• Diamondbacks / Cubs TV Channel: MARQ | DBTV

The Arizona Diamondbacks (+135) visit Wrigley Field to take on the Chicago Cubs (-160) on May 3, 2026. First pitch is scheduled for 2:20 pm in Chicago, IL.

This season, the Diamondbacks are 16-16 against the spread (ATS), while the Cubs are 16-17 ATS.

Diamondbacks vs Cubs Starting Pitchers Today:

• Diamondbacks starting pitcher: Merrill Kelly 1-2, 9.21 ERA
• Cubs starting pitcher: Matthew Boyd 1-1, 7.14 ERA

Diamondbacks vs. Cubs Odds, Run Line, Over/Under & Moneyline

Diamondbacks vs Cubs Prediction for Today’s Game

Based on recent trends the model predicts the Cubs will win Sunday‘s MLB game with 56.5% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Diamondbacks vs Cubs and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Diamondbacks players for Sunday‘s game, looking at profitable historical betting trends:

Best Diamondbacks Player Prop Bets Today:

• Ildemaro Vargas has hit the Hits Over in 22 of his last 25 games (+18.30 Units / 40% ROI)
• Ildemaro Vargas has hit the Home Runs Over in 3 of his last 10 games (+17.60 Units / 176% ROI)
• Ildemaro Vargas has hit the Hits Runs and RBIs Over in 16 of his last 20 away games (+13.00 Units / 58% ROI)
• Jose Fernandez has hit the Singles Over in 16 of his last 20 games (+12.70 Units / 59% ROI)
• Ildemaro Vargas has hit the Runs Over in 13 of his last 20 games (+12.25 Units / 59% ROI)

And here are some favorite MLB player prop bets for Cubs players for Sunday‘s game, looking at profitable historical betting trends:

Best Cubs Player Prop Best Bets Today:

• Seiya Suzuki has hit the Home Runs Over in 5 of his last 10 games (+18.50 Units / 185% ROI)
• Ian Happ has hit the Runs Over in 14 of his last 20 games at home (+11.45 Units / 53% ROI)
• Seiya Suzuki has hit the Total Bases Over in 15 of his last 20 games at home (+10.75 Units / 41% ROI)
• Carson Kelly has hit the Singles Over in 12 of his last 15 games (+10.35 Units / 67% ROI)
• Ian Happ has hit the Walks Over in 12 of his last 15 games at home (+10.35 Units / 66% ROI)

Diamondbacks Best Bets Today:

• The Arizona Diamondbacks have hit the Team Total Over in 32 of their last 50 games (+13.45 Units / 24% ROI)
• The Arizona Diamondbacks have hit the 1st Five Innings (F5) Team Total Over in 21 of their last 30 away games (+11.70 Units / 33% ROI)
• The Arizona Diamondbacks have hit the Game Total Over in 29 of their last 50 games (+9.45 Units / 17% ROI)
• The Arizona Diamondbacks have covered the Run Line in 20 of their last 30 games (+5.80 Units / 13% ROI)
• The Arizona Diamondbacks have hit the 1st Five Innings (F5) Moneyline in 15 of their last 30 games (+4.20 Units / 12% ROI)

Cubs Best Bets Today:

• The Chicago Cubs have hit the Team Total Over in 19 of their last 25 games (+12.75 Units / 44% ROI)
• The Chicago Cubs have covered the 1st Five Innings (F5) Run Line in 29 of their last 45 games at home (+11.95 Units / 22% ROI)
• The Chicago Cubs have hit the Moneyline in 14 of their last 17 games (+11.75 Units / 57% ROI)
• The Chicago Cubs have hit the Game Total Over in 18 of their last 25 games (+11.40 Units / 41% ROI)
• The Chicago Cubs have hit the 1st Five Innings (F5) Moneyline in 30 of their last 50 games at home (+11.30 Units / 15% ROI)

Diamondbacks Against the Spread (ATS) Record

Against the spread this season, the Diamondbacks are 21-11 against the Run Line (+5.8 Units / 12.31% ROI).

• 16-16 when betting on the Moneyline for +1.25 Units / 3.55% ROI
• 19-12 when betting on the total runs Over for +6.15 Units / 17.52% ROI
• 12-19 when betting on the total runs Under for -8.75 Units / -24.72% ROI

Cubs Against the Spread (ATS) Record

Against the spread this season, the Cubs are 16-17 against the Run Line (-0.55 Units / -1.39% ROI).

• 21-12 when betting on the Moneyline for +5.4 Units / 12.08% ROI
• 21-11 when betting on the total runs Over for +9.15 Units / 25.17% ROI
• 11-21 when betting on the total runs Under for -12.05 Units / -33.1% ROI

Cubs vs Diamondbacks Home Run Prop Bets Today

Cubs vs Diamondbacks Total Hits Prop Bets Today

Cubs vs Diamondbacks Strikeout Prop Bets Today

Diamondbacks Keys to the Game vs. the Cubs

The Diamondbacks are just 71-21 (.772) when leading entering the 7th inning since the 2025 season — 2nd lowest in MLB; League Avg: .871.

The Diamondbacks are just 79-15 (.840) when leading entering the 8th inning since the 2025 season — 2nd lowest in MLB; League Avg: .906.

The Diamondbacks are just 0-13 (.000) when trailing entering the 9th inning this season — tied for lowest in MLB; League Avg: .058.

The Diamondbacks are just 10-4 (.714) when leading entering the 7th inning this season — 3rd lowest in MLB; League Avg: .853.

Cubs Keys to the Game vs. the Diamondbacks

The Cubs are 45-9 (.833) when they’ve scored in the first inning since the 2025 season — best in MLB; League Avg: .636.

The Cubs are 59-7 (.894) when they’ve had 10 or more hits since the 2025 season — best in MLB; League Avg: .745.

The Cubs are 17-0 (1.000) when leading entering the 7th inning this season — tied for best in MLB; League Avg: .853.

The Cubs are 13-7 (.650) after a win this season — 5th best in MLB; League Avg: .528.

Diamondbacks Hitting Stats & Trends

Diamondbacks hitters have a swing rate of just 23% on the first pitch of at-bats this season — lowest in MLB.

Diamondbacks hitters have an OBP of just .288 (814 PA’s) against RHP this season — 2nd lowest in MLB.

Diamondbacks hitters have chased 47% of pitches out of the zone with two-strikes this season — highest in MLB.

Diamondbacks hitters are slugging .560 with runners in scoring position this season — best in MLB.

Cubs Hitting Stats & Trends

Cubs hitters have an OBP of .374 (438 PA’s) against LHP this season — best in MLB.

Cubs hitters are slugging .459 against LHP this season — best in MLB.

Cubs hitters have an OPS of .833 (438 PA’s) against LHP this season — best in MLB.

Cubs hitters have an OPS of .762 (3,764 PA’s) on the road since the 2025 season — 2nd best in MLB.

Diamondbacks Pitching Stats & Trends

Diamondbacks pitchers have a strikeout rate of just 19% this season — 3rd lowest in MLB.

Diamondbacks pitchers have a strikeout rate of just 20% since the 2025 season — 4th lowest in MLB.

Diamondbacks pitchers have struck out just 18% of left-handed batters they faced this season — 2nd lowest in MLB.

Diamondbacks pitchers have walked 6% of batters when facing the leadoff batter in the inning this season — tied for 2nd best in MLB.

Cubs Pitching Stats & Trends

Cubs pitchers have walked 7% of batters since the 2025 season — best in MLB.

Cubs pitchers have a strikeout rate of just 16% when facing the leadoff batter in the inning this season — 2nd lowest in MLB.

Cubs pitchers have walked 8% of batters this season — 3rd best in MLB.

Cubs pitchers have an ERA of 2.93 (166.0 IP) at home this season — 5th best in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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