Diamondbacks vs Giants Prediction, Odds & Player Prop Bets Today – MLB, May 25

San Francisco Giants designated hitter Rafael Devers rounds the bases after hitting a solo home run during the fourth inning of a baseball game against the Colorado Rockies, Sunday, Sept. 28, 2025, in San Francisco. (AP Photo/Thien-An Truong)
(AP Photo/Thien-An Truong)
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The Arizona Diamondbacks (+115) visit Oracle Park to take on the San Francisco Giants (-140) on May 25, 2026. First pitch is scheduled for 5:05 pm in San Francisco, CA.

This season, the Diamondbacks are 28-24 against the spread (ATS), while the Giants are 22-30 ATS.

Diamondbacks vs Giants Starting Pitchers Today:

  • Diamondbacks starting pitcher: Merrill Kelly 4-3, 5.67 ERA
  • Giants starting pitcher: Landen Roupp 5-4, 3.30 ERA

Diamondbacks vs. Giants Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Diamondbacks+1.5 -190O 7.5 -105+115
Giants -1.5 +155U 7.5 -115-140

Diamondbacks vs Giants Prediction for Today’s Game

Based on recent trends the model predicts the Giants will win Monday‘s MLB game with 58.9% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


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We’ve highlighted some favorite MLB player prop bets for Diamondbacks players for Monday‘s game, looking at profitable historical betting trends:

Best Diamondbacks Player Prop Bets Today:

  • Ildemaro Vargas has hit the Hits Runs and RBIs Over in 18 of his last 25 away games (+11.15 Units / 41% ROI)
  • Ildemaro Vargas has hit the Singles Over in 19 of his last 25 away games (+10.90 Units / 33% ROI)
  • Ildemaro Vargas has hit the Hits Over in 15 of his last 20 away games (+8.40 Units / 24% ROI)
  • Ketel Marte has hit the RBIs Under in his last 8 away games (+8.00 Units / 51% ROI)
  • Corbin Carroll has hit the Walks Over in 6 of his last 7 away games (+6.35 Units / 89% ROI)

And here are some favorite MLB player prop bets for Giants players for Monday‘s game, looking at profitable historical betting trends:

Best Giants Player Prop Best Bets Today:

  • Bryce Eldridge has hit the Singles Under in 16 of his last 20 games (+9.40 Units / 27% ROI)
  • Bryce Eldridge has hit the Hits Under in 13 of his last 20 games (+8.50 Units / 41% ROI)
  • Bryce Eldridge has hit the Hits Runs and RBIs Under in 14 of his last 20 games (+7.20 Units / 29% ROI)
  • Landen Roupp has hit the Walks Allowed Under in 11 of his last 15 games (+7.10 Units / 35% ROI)
  • Landen Roupp has hit the Strikeouts Over in 11 of his last 15 games (+6.80 Units / 37% ROI)
  • team high – away
  • team high – home

Diamondbacks Against the Spread (ATS) Record

Against the spread this season, the Diamondbacks are 31-20 against the Run Line (+5.25 Units / 7.41% ROI).

  • 28-24 when betting on the Moneyline for +2.4 Units / 4% ROI
  • 26-24 when betting on the total runs Over for -1.35 Units / -2.4% ROI
  • 24-26 when betting on the total runs Under for -3.3 Units / -5.9% ROI

Giants Against the Spread (ATS) Record

Against the spread this season, the Giants are 22-30 against the Run Line (-20.65 Units / -27.5% ROI).

  • 22-31 when betting on the Moneyline for -7.55 Units / -13.51% ROI
  • 25-25 when betting on the total runs Over for -3.45 Units / -6.02% ROI
  • 25-25 when betting on the total runs Under for -1.3 Units / -2.28% ROI

Giants vs Diamondbacks Home Run Prop Bets Today

Yes
Rafael Devers +390
Willy Adames +450
Matt Chapman +550
Corbin Carroll +550
Ketel Marte +550

Giants vs Diamondbacks Total Hits Prop Bets Today

Over Under
Willy Adames 0.5 -225 0.5 +165
Ketel Marte 0.5 -225 0.5 +165
Geraldo Perdomo 0.5 -210 0.5 +155
Gabriel Moreno 0.5 -200 0.5 +150
Corbin Carroll 0.5 -200 0.5 +150

Giants vs Diamondbacks Strikeout Prop Bets Today

Over Under
Bryce Eldridge 0.5 -275 0.5 +190
Ryan Waldschmidt 0.5 -275 0.5 +195
Corbin Carroll 0.5 -250 0.5 +180
Willy Adames 0.5 -235 0.5 +175
Gabriel Moreno 0.5 -220 0.5 +165

Diamondbacks Keys to the Game vs. the Giants

The Diamondbacks are 5-15 (.250) when trailing entering the 7th inning this season — 2nd best in MLB; League Avg: .137.

The Diamondbacks are just 82-22 (.788) when leading entering the 7th inning since the 2025 season — 2nd lowest in MLB; League Avg: .872.

The Diamondbacks are just 90-16 (.849) when leading entering the 8th inning since the 2025 season — 2nd lowest in MLB; League Avg: .906.

The Diamondbacks are 7-84 (.077) when trailing entering the 9th inning since the 2025 season — 3rd best in MLB; League Avg: .046.

Giants Keys to the Game vs. the Diamondbacks

The Giants are just 5-29 (.147) when scoring 4 or fewer runs this season — lowest in MLB; League Avg: .283.

The Giants are 10-0 (1.000) when they’ve had 5 or more XBH this season — tied for best in MLB; League Avg: .791.

The Giants are just 0-27 (.000) when trailing entering the 9th inning this season — tied for lowest in MLB; League Avg: .053.

The Giants are just 16-5 (.762) when leading entering the 7th inning this season — 2nd lowest in MLB; League Avg: .863.

Diamondbacks hitters have struck out in just 17% of their PA’s against LHP this season — best in MLB.

The Diamondbacks are batting .351 in lefty-lefty matchups this season — best in MLB.

The Diamondbacks are batting .282 against LHP this season — best in MLB.

Diamondbacks hitters are slugging .452 against LHP this season — 2nd best in MLB.

Giants hitters have drawn walks in 6% of their PA’s against RHP this season — lowest in MLB.

The Giants have an average HR distance of 379.3 feet this season — lowest in MLB.

Giants hitter’ K:BB ratio is 3.8 against RHP this season — highest in MLB.

Giants hitters have drawn walks in 6% of their PA’s this season — lowest in MLB.

Diamondbacks pitchers have walked 6% of batters when facing the leadoff batter in the inning this season — 2nd best in MLB.

Opponents have a miss rate of just 23% against Diamondbacks pitchers this season — tied for 2nd lowest in MLB.

Diamondbacks pitchers have walked 8% of batters this season — 4th best in MLB.

Diamondbacks pitchers have struck out just 18% of left-handed batters they faced this season — lowest in MLB.

Opponents have a groundball rate of 48% against Giants pitchers this season — 2nd highest in MLB.

Giants pitchers have thrown at least two strikes in their first three pitches to 56% of opposing batters this season — lowest in MLB.

Giants pitchers have induced opposing hitters to ground into 49 double plays in 391 opportunities (12%) this season — best in MLB.

Opponents have a groundball batting average of just .214 against Giants pitchers this season — 2nd best in MLB.

More MLB Reading:


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Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.