• The Diamondbacks are -140 favorites vs the Giants
• Diamondbacks vs Giants Over / Under today: 7.5 Runs
• Diamondbacks / Giants TV Channel: NSBA | DBTV

The Arizona Diamondbacks (-140) visit Oracle Park to take on the San Francisco Giants (+115) on May 27, 2026. First pitch is scheduled for 3:45 pm in San Francisco, CA.

This season, the Diamondbacks are 30-24 against the spread (ATS), while the Giants are 22-32 ATS.

Diamondbacks vs Giants Starting Pitchers Today:

• Diamondbacks starting pitcher: Mike Soroka 6-2, 3.30 ERA
• Giants starting pitcher: Trevor McDonald 2-1, 4.70 ERA

Diamondbacks vs. Giants Odds, Run Line, Over/Under & Moneyline

Diamondbacks vs Giants Prediction for Today’s Game

Based on recent trends the model predicts the Diamondbacks will win Wednesday‘s MLB game with 56.4% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Diamondbacks vs Giants and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Diamondbacks players for Wednesday‘s game, looking at profitable historical betting trends:

Best Diamondbacks Player Prop Bets Today:

• Gabriel Moreno has hit the Home Runs Over in 2 of his last 7 games (+14.00 Units / 200% ROI)
• Ildemaro Vargas has hit the Hits Over in 20 of his last 25 away games (+13.40 Units / 30% ROI)
• Adrian Del Castillo has hit the Runs Under in 21 of his last 25 games (+12.60 Units / 26% ROI)
• Ketel Marte has hit the Total Bases Over in 13 of his last 15 games (+11.90 Units / 72% ROI)
• Ildemaro Vargas has hit the Hits Runs and RBIs Over in 18 of his last 25 away games (+11.15 Units / 41% ROI)

And here are some favorite MLB player prop bets for Giants players for Wednesday‘s game, looking at profitable historical betting trends:

Best Giants Player Prop Best Bets Today:

• Casey Schmitt has hit the Home Runs Over in 5 of his last 10 games at home (+25.20 Units / 252% ROI)
• Rafael Devers has hit the Hits Over in 21 of his last 25 games (+13.20 Units / 29% ROI)
• Rafael Devers has hit the Walks Under in 17 of his last 20 games (+12.60 Units / 36% ROI)
• Rafael Devers has hit the Total Bases Over in 18 of his last 25 games (+12.40 Units / 39% ROI)
• Willy Adames has hit the Hits Runs and RBIs Over in 16 of his last 20 games (+11.85 Units / 50% ROI)

Diamondbacks Best Bets Today:

• The Arizona Diamondbacks have hit the Team Total Over in 34 of their last 50 away games (+16.40 Units / 28% ROI)
• The Arizona Diamondbacks have hit the 1st Five Innings (F5) Team Total Under in 23 of their last 35 games (+10.55 Units / 26% ROI)
• The Arizona Diamondbacks have hit the Game Total Over in 21 of their last 35 away games (+8.00 Units / 21% ROI)
• The Arizona Diamondbacks have hit the Moneyline in 29 of their last 50 games (+7.55 Units / 13% ROI)
• The Arizona Diamondbacks have hit the 1st Five Innings (F5) Moneyline in 12 of their last 17 games (+7.20 Units / 30% ROI)

Giants Best Bets Today:

• The San Francisco Giants have hit the Team Total Over in 29 of their last 45 games at home (+10.55 Units / 19% ROI)
• The San Francisco Giants have hit the 1st Five Innings (F5) Team Total Over in 9 of their last 10 games (+8.20 Units / 61% ROI)
• The San Francisco Giants have hit the Game Total Over in 28 of their last 50 games at home (+8.10 Units / 15% ROI)
• The San Francisco Giants have hit the Moneyline in 11 of their last 19 games at home (+3.70 Units / 17% ROI)

Diamondbacks Against the Spread (ATS) Record

Against the spread this season, the Diamondbacks are 33-20 against the Run Line (+8.6 Units / 11.51% ROI).

• 30-24 when betting on the Moneyline for +5.55 Units / 8.66% ROI
• 27-24 when betting on the total runs Over for +0.65 Units / 1.09% ROI
• 24-27 when betting on the total runs Under for -5.5 Units / -9.28% ROI

Giants Against the Spread (ATS) Record

Against the spread this season, the Giants are 22-32 against the Run Line (-21.5 Units / -27.35% ROI).

• 22-33 when betting on the Moneyline for -9 Units / -15.1% ROI
• 26-25 when betting on the total runs Over for -1.45 Units / -2.39% ROI
• 25-26 when betting on the total runs Under for -3.5 Units / -5.8% ROI

Giants vs Diamondbacks Home Run Prop Bets Today

Giants vs Diamondbacks Total Hits Prop Bets Today

Giants vs Diamondbacks Strikeout Prop Bets Today

Diamondbacks Keys to the Game vs. the Giants

The Diamondbacks are 5-15 (.250) when trailing entering the 7th inning this season — 2nd best in MLB; League Avg: .136.

The Diamondbacks are 17-6 (.739) vs bottom 10 scoring offenses this season Today, they face the Giants (30th in runs scored).

The Diamondbacks are just 84-22 (.792) when leading entering the 7th inning since the 2025 season — 3rd lowest in MLB; League Avg: .872.

The Diamondbacks are 7-84 (.077) when trailing entering the 9th inning since the 2025 season — 3rd best in MLB; League Avg: .046.

Giants Keys to the Game vs. the Diamondbacks

The Giants are just 0-28 (.000) when trailing entering the 8th inning this season — tied for lowest in MLB; League Avg: .102.

The Giants are just 5-30 (.143) when scoring 4 or fewer runs this season — lowest in MLB; League Avg: .281.

The Giants are just 0-29 (.000) when trailing entering the 9th inning this season — tied for lowest in MLB; League Avg: .053.

The Giants are just 0-26 (.000) when trailing entering the 7th inning this season — tied for lowest in MLB; League Avg: .136.

Diamondbacks Hitting Stats & Trends

Diamondbacks hitters have put 42% of their swings in play against LHP this season — highest in MLB.

Diamondbacks hitters are slugging .455 against LHP this season — 2nd best in MLB.

Diamondbacks hitters have an OPS of .798 (586 PA’s) against LHP this season — 2nd best in MLB.

Diamondbacks hitters have struck out in just 17% of their PA’s against LHP this season — best in MLB.

Giants Hitting Stats & Trends

Giants hitters have drawn walks in 6% of their PA’s against LHP this season — 2nd lowest in MLB.

Giants hitters have drawn walks in 6% of their PA’s against RHP this season — lowest in MLB.

Giants hitters have an OBP of just .224 (1,075 PA’s) with two-strikes this season — 3rd lowest in MLB.

Giants hitter’ K:BB ratio is 3.6 this season — highest in MLB.

Diamondbacks Pitching Stats & Trends

Diamondbacks pitchers have a strikeout rate of just 19% this season — 2nd lowest in MLB.

Opponents have a miss rate of just 23% against Diamondbacks pitchers this season — 2nd lowest in MLB.

Diamondbacks pitchers have walked 6% of batters when facing the leadoff batter in the inning this season — 2nd best in MLB.

Diamondbacks pitchers have a strikeout rate of just 40% with two-strikes this season — tied for 5th lowest in MLB.

Giants Pitching Stats & Trends

Giants pitchers have thrown at least two strikes in their first three pitches to 57% of opposing batters this season — lowest in MLB.

Opponents have a groundball rate of 47% against Giants pitchers this season — 2nd highest in MLB.

Giants pitchers have a strikeout rate of just 19% with runners in scoring position this season — 4th lowest in MLB.

Giants pitchers have induced opposing hitters to ground into 51 double plays in 412 opportunities (12%) this season — best in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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