• The Diamondbacks are -145 favorites vs the Padres
• Diamondbacks vs Padres Over / Under today: 8 Runs
• Diamondbacks / Padres TV Channel: DBTV | PDTV

The Arizona Diamondbacks (-145) visit Petco Park to take on the San Diego Padres (+120) on September 27, 2026. First pitch is scheduled for 3:10 pm in San Diego, CA.

This season, the Diamondbacks are 86-75 against the spread (ATS), while the Padres are 88-70 ATS.

Diamondbacks vs Padres Starting Pitchers Today:

• Diamondbacks starting pitcher: Mike Soroka 9-5, 3.34 ERA
• Padres starting pitcher: Randy Vasquez 10-6, 4.02 ERA

Diamondbacks vs. Padres Odds, Run Line, Over/Under & Moneyline

Diamondbacks vs Padres Prediction for Today’s Game

Based on recent trends the model predicts the Diamondbacks will win Sunday‘s MLB game with 51.0% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Diamondbacks vs Padres and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Diamondbacks players for Sunday‘s game, looking at profitable historical betting trends:

Best Diamondbacks Player Prop Bets Today:

• Nolan Arenado has hit the Home Runs Over in 5 of his last 9 games (+23.90 Units / 266% ROI)
• Gabriel Moreno has hit the RBIs Over in 11 of his last 15 away games (+14.20 Units / 95% ROI)
• Gabriel Moreno has hit the Total Bases Over in 15 of his last 20 away games (+13.65 Units / 65% ROI)
• Nolan Arenado has hit the Hits Over in 13 of his last 15 games (+11.75 Units / 49% ROI)
• Gabriel Moreno has hit the Hits Runs and RBIs Over in 19 of his last 25 away games (+11.55 Units / 37% ROI)

And here are some favorite MLB player prop bets for Padres players for Sunday‘s game, looking at profitable historical betting trends:

Best Padres Player Prop Best Bets Today:

• Gavin Sheets has hit the Total Bases Under in 18 of his last 25 games at home (+12.95 Units / 45% ROI)
• Jake Cronenworth has hit the Home Runs Over in 2 of his last 8 games at home (+12.00 Units / 150% ROI)
• Gavin Sheets has hit the Hits Under in 17 of his last 25 games at home (+11.90 Units / 47% ROI)
• Michael King has hit the Pitching Outs Over in 19 of his last 25 games (+11.85 Units / 38% ROI)
• Fernando Tatis Jr. has hit the Runs Over in 18 of his last 25 games (+10.75 Units / 33% ROI)

Diamondbacks Best Bets Today:

• The Arizona Diamondbacks have hit the Moneyline in 23 of their last 35 away games (+15.70 Units / 40% ROI)
• The Arizona Diamondbacks have hit the Game Total Under in 32 of their last 50 away games (+12.50 Units / 23% ROI)
• The Arizona Diamondbacks have hit the 1st Five Innings (F5) Team Total Over in their last 8 games (+8.35 Units / 81% ROI)
• The Arizona Diamondbacks have covered the Run Line in 6 of their last 7 games (+5.40 Units / 65% ROI)
• The Arizona Diamondbacks have hit the 1st Five Innings (F5) Moneyline in 6 of their last 7 games (+5.25 Units / 56% ROI)

Padres Best Bets Today:

• The San Diego Padres have hit the Moneyline in 33 of their last 45 games at home (+19.00 Units / 32% ROI)
• The San Diego Padres have hit the Team Total Over in 15 of their last 17 games (+12.85 Units / 65% ROI)
• The San Diego Padres have hit the 1st Five Innings (F5) Team Total Over in 15 of their last 19 games (+11.35 Units / 52% ROI)
• The San Diego Padres have covered the 1st Five Innings (F5) Run Line in 21 of their last 30 games (+11.20 Units / 32% ROI)
• The San Diego Padres have hit the 1st Five Innings (F5) Moneyline in 14 of their last 19 games (+10.90 Units / 40% ROI)

Diamondbacks Against the Spread (ATS) Record

Against the spread this season, the Diamondbacks are 84-72 against the Run Line (+0.65 Units / 0.31% ROI).

• 86-75 when betting on the Moneyline for +10.05 Units / 5.27% ROI
• 70-85 when betting on the total runs Over for -23.6 Units / -13.28% ROI
• 85-70 when betting on the total runs Under for +8.5 Units / 4.81% ROI

Padres Against the Spread (ATS) Record

Against the spread this season, the Padres are 88-70 against the Run Line (+12.95 Units / 6.15% ROI).

• 90-71 when betting on the Moneyline for +13.55 Units / 6.81% ROI
• 76-80 when betting on the total runs Over for -12.1 Units / -6.8% ROI
• 80-76 when betting on the total runs Under for -2.95 Units / -1.67% ROI

Diamondbacks Keys to the Game vs. the Padres

The Diamondbacks are 72-0 (1.000) when leading entering the 9th inning this season — tied for best in MLB.

The Diamondbacks were just 67-7 (.905) when leading entering the 9th inning in the 2025 season — 2nd lowest in MLB; League Avg: .956.

The Diamondbacks were just 67-13 (.838) when leading entering the 8th inning in the 2025 season — tied for 2nd lowest in MLB; League Avg: .909.

The Diamondbacks are 15-189 (.073) when trailing entering the 9th inning since the 2024 season — 2nd best in MLB.

Padres Keys to the Game vs. the Diamondbacks

The Padres are 50-30 (.625) at home this season — 5th best in MLB.

The Padres are 72-2 (.973) when leading entering the 8th inning this season — tied for 2nd best in MLB.

The Padres are 64-8 (.889) when scoring 5 or more runs this season — 2nd best in MLB.

The Padres are 26-21 (.553) vs the top 10 runs allowed teams this season Today, they face Diamondbacks (15th fewest runs allowed).

Diamondbacks Hitting Stats & Trends

The Diamondbacks are batting .276 against LHP this season — best in MLB.

Diamondbacks hitters have struck out in just 18% of their PA’s against LHP this season — 2nd best in MLB.

Diamondbacks hitters have an OPS of .783 (1,674 PA’s) against LHP this season — 2nd best in MLB.

Diamondbacks hitters have a swing rate of just 25% on the first pitch of at-bats this season — lowest in MLB.

Padres Hitting Stats & Trends

The Padres have answered-back in 37% of innings after an opponent scores in late innings this season — highest in MLB.

Padres hitters have grounded into 124 double plays in 1,067 opportunities (12%) this season — 2nd highest in MLB.

The Padres are batting .367 on the first pitch of at-bats this season — 2nd best in MLB.

The Padres have won 94% of home games in which they have scored three or more runs in an inning this season — 2nd highest in MLB.

Diamondbacks Pitching Stats & Trends

Diamondbacks pitchers have a strikeout rate of just 19% this season — 2nd lowest in MLB.

Diamondbacks pitchers have walked 7% of batters when facing the leadoff batter in the inning this season — 3rd best in MLB.

Diamondbacks pitchers have walked 8% of batters this season — tied for 4th best in MLB.

Opponents have a miss rate of just 23% against Diamondbacks pitchers this season — 2nd lowest in MLB.

Padres Pitching Stats & Trends

Padres pitchers have won 35% of games in which they have allowed their opponent to score in three different innings this season — 3rd highest in MLB.

The Padres have allowed 1.09 runs per game (176/161) in late innings this season — 2nd best in MLB.

The Padres have won 46% of home games in which their opponents scored first this season — 2nd highest in MLB.

Padres pitchers have a strikeout rate of just 14% when going through the lineup the third time in a game this season — lowest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

Bet now on Diamondbacks vs Padres and all games with BetMGM

Bet on MLB Odds at BetMGM

Sportsbook promos are always available at BetMGM. For new customers, check out the sportsbook welcome offer and BetMGM Refer a Friend. For existing customers, there are Odds Boosts, Parlay Boosts, contests and more.