Dodgers vs Giants Prediction, Odds & Player Prop Bets Today – MLB, Apr 21

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  • The Dodgers are -190 favorites vs the Giants
  • Dodgers vs Giants Over / Under today: 7 Runs
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The Los Angeles Dodgers (-190) visit Oracle Park to take on the San Francisco Giants (+155) on April 21, 2026. First pitch is scheduled for 9:45 pm in San Francisco, CA.

This season, the Dodgers are 16-6 against the spread (ATS), while the Giants are 7-14 ATS.

Dodgers vs Giants Starting Pitchers Today:

  • Dodgers starting pitcher: Yoshinobu Yamamoto 2-1, 2.11 ERA
  • Giants starting pitcher: Landen Roupp 3-1, 2.38 ERA

Dodgers vs. Giants Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Dodgers-1.5 -110O 7 -105-190
Giants +1.5 -110U 7 -115+155

Dodgers vs Giants Prediction for Today’s Game

Based on recent trends the model predicts the Dodgers will win Tuesday‘s MLB game with 59.8% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


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We’ve highlighted some favorite MLB player prop bets for Dodgers players for Tuesday‘s game, looking at profitable historical betting trends:

Best Dodgers Player Prop Bets Today:

  • Shohei Ohtani has hit the Walks Under in 11 of his last 15 away games (+8.25 Units / 47% ROI)
  • Shohei Ohtani has hit the Hits Over in 11 of his last 15 away games (+8.10 Units / 36% ROI)
  • Kyle Tucker has hit the Home Runs Over in 2 of his last 4 games (+8.00 Units / 200% ROI)
  • Andy Pages has hit the Singles Over in 14 of his last 20 games (+7.70 Units / 32% ROI)
  • Alex Freeland has hit the Runs Under in 12 of his last 15 games (+7.05 Units / 25% ROI)

And here are some favorite MLB player prop bets for Giants players for Tuesday‘s game, looking at profitable historical betting trends:

Best Giants Player Prop Best Bets Today:

  • Matt Chapman has hit the Walks Under in 18 of his last 20 games (+15.00 Units / 42% ROI)
  • Matt Chapman has hit the Singles Over in 15 of his last 20 games (+11.80 Units / 57% ROI)
  • Heliot Ramos has hit the Home Runs Over in 2 of his last 4 games (+11.10 Units / 278% ROI)
  • Matt Chapman has hit the Hits Over in 16 of his last 20 games (+8.45 Units / 22% ROI)
  • Patrick Bailey has hit the Runs Under in his last 8 games (+8.00 Units / 44% ROI)
  • The Los Angeles Dodgers have hit the Moneyline in 38 of their last 50 games (+14.80 Units / 16% ROI)
  • The Los Angeles Dodgers have hit the 1st Five Innings (F5) Moneyline in 15 of their last 25 away games (+10.00 Units / 24% ROI)
  • The Los Angeles Dodgers have covered the Run Line in 15 of their last 22 away games (+8.40 Units / 30% ROI)
  • The Los Angeles Dodgers have hit the Team Total Over in 15 of their last 23 away games (+7.05 Units / 27% ROI)
  • The Los Angeles Dodgers have hit the 1st Five Innings (F5) Team Total Over in 18 of their last 30 away games (+3.85 Units / 10% ROI)
  • The San Francisco Giants have hit the Team Total Under in 16 of their last 24 games (+7.40 Units / 28% ROI)
  • The San Francisco Giants have hit the 1st Five Innings (F5) Team Total Under in 29 of their last 50 games at home (+6.70 Units / 12% ROI)
  • The San Francisco Giants have hit the Game Total Over in 14 of their last 25 games at home (+4.10 Units / 15% ROI)
  • The San Francisco Giants have covered the 1st Five Innings (F5) Run Line in 10 of their last 15 games at home (+3.65 Units / 18% ROI)
  • The San Francisco Giants have hit the 1st Five Innings (F5) Moneyline in 14 of their last 30 games at home (+3.00 Units / 7% ROI)

Dodgers Against the Spread (ATS) Record

Against the spread this season, the Dodgers are 12-10 against the Run Line (+1.15 Units / 4.21% ROI).

  • 16-6 when betting on the Moneyline for +3.5 Units / 7.35% ROI
  • 11-11 when betting on the total runs Over for -1.25 Units / -5.13% ROI
  • 11-11 when betting on the total runs Under for -1.1 Units / -4.57% ROI

Giants Against the Spread (ATS) Record

Against the spread this season, the Giants are 7-14 against the Run Line (-11.95 Units / -38.74% ROI).

  • 9-13 when betting on the Moneyline for -4.7 Units / -19.5% ROI
  • 10-9 when betting on the total runs Over for +0.25 Units / 1.04% ROI
  • 9-10 when betting on the total runs Under for -2.05 Units / -8.44% ROI

Giants vs Dodgers Home Run Prop Bets Today

Yes
Shohei Ohtani +375
Willy Adames +600
Max Muncy +625
Rafael Devers +650
Teoscar Hernandez +675

Giants vs Dodgers Total Hits Prop Bets Today

Over Under
Shohei Ohtani 0.5 -225 0.5 +165
Kyle Tucker 0.5 -200 0.5 +145
Will Smith 0.5 -200 0.5 +150
Teoscar Hernandez 0.5 -190 0.5 +140
Andy Pages 0.5 -190 0.5 +140

Giants vs Dodgers Strikeout Prop Bets Today

Over Under
Andy Pages 0.5 -275 0.5 +195
Hyeseong Kim 0.5 -250 0.5 +180
Heliot Ramos 0.5 -235 0.5 +175
Will Smith 0.5 -210 0.5 +155
Patrick Bailey 0.5 -200 0.5 +150

Dodgers Keys to the Game vs. the Giants

The Dodgers are 2-4 (.333) when trailing entering the 7th inning this season — tied for 2nd best in MLB; League Avg: .133.

The Dodgers are 2-5 (.286) when trailing entering the 8th inning this season — tied for best in MLB; League Avg: .107.

The Dodgers are 16-6 (.727) this season — best in MLB; League Avg: .500.

The Dodgers are 86-16 (.843) when scoring 5 or more runs since the 2025 season — 4th best in MLB; League Avg: .793.

Giants Keys to the Game vs. the Dodgers

The Giants were just 65-6 (.915) when leading entering the 9th inning in the 2025 season — 3rd lowest in MLB; League Avg: .956.

The Giants are just 3-7 (.300) at home this season — 2nd lowest in MLB; League Avg: .546.

The Giants are just 74-6 (.925) when leading entering the 9th inning since the 2025 season — 3rd lowest in MLB; League Avg: .955.

The Giants are just 0-13 (.000) when trailing entering the 9th inning this season — tied for lowest in MLB; League Avg: .052.

Dodgers hitters have an OPS of .873 (863 PA’s) this season — best in MLB.

The Dodgers are batting .293 this season — best in MLB.

Dodgers hitters have an OPS of .954 (436 PA’s) on the road this season — best in MLB.

Dodgers hitters have an OPS of .877 (637 PA’s) against RHP this season — best in MLB.

The Giants batted just .214 against LHP in the 2025 season — lowest in MLB.

Giants hitters have an OBP of just .284 (1,872 PA’s) against LHP since the 2025 season — lowest in MLB.

Giants hitters had an OPS of just .631 (1,623 PA’s) against LHP in the 2025 season — lowest in MLB.

Giants hitters have an OPS of just .641 (1,872 PA’s) against LHP since the 2025 season — lowest in MLB.

Dodgers pitchers had a strikeout rate of 25% in the 2025 season — 2nd best in MLB.

Dodgers pitchers had a strikeout rate of 46% with two-strikes in the 2025 season — 3rd best in MLB.

Dodgers pitchers have a strikeout rate of 25% since the 2025 season — 2nd best in MLB.

Dodgers pitchers walked 9% of batters in the 2025 season — 3rd highest in MLB.

Opponents had a groundball rate of 46% against Giants pitchers in the 2025 season — 3rd highest in MLB.

Opponents have a groundball rate of 47% against Giants pitchers this season — 3rd highest in MLB.

The Giants allowed 1.02 runs per game (165/161) in late innings in the 2025 season — best in MLB.

Giants pitchers have allowed an OBP of .359 (195 PA’s) when facing the leadoff batter in the inning this season — highest in MLB.

More MLB Reading:


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Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.