• The Dodgers are -220 favorites vs the Giants
• Dodgers vs Giants Over / Under today: 7.5 Runs
• Dodgers / Giants TV Channel: NSBA | SNLA

The Los Angeles Dodgers (-220) visit Oracle Park to take on the San Francisco Giants (+180) on April 22, 2026. First pitch is scheduled for 9:45 pm in San Francisco, CA.

This season, the Dodgers are 16-7 against the spread (ATS), while the Giants are 8-14 ATS.

Dodgers vs Giants Starting Pitchers Today:

• Dodgers starting pitcher: Shohei Ohtani 2-0, 0.50 ERA
• Giants starting pitcher: Tyler Mahle 0-3, 7.37 ERA

Dodgers vs. Giants Odds, Run Line, Over/Under & Moneyline

Dodgers vs Giants Prediction for Today’s Game

Based on recent trends the model predicts the Dodgers will win Wednesday‘s MLB game with 61.7% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Dodgers vs Giants and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Dodgers players for Wednesday‘s game, looking at profitable historical betting trends:

Best Dodgers Player Prop Bets Today:

• Freddie Freeman has hit the Hits Over in 18 of his last 25 away games (+10.45 Units / 24% ROI)
• Hye Seong Kim has hit the Home Runs Over in 1 of his last 4 games (+9.00 Units / 225% ROI)
• Shohei Ohtani has hit the Walks Under in 14 of his last 20 away games (+8.65 Units / 35% ROI)
• Shohei Ohtani has hit the Singles Over in 13 of his last 20 away games (+8.45 Units / 39% ROI)
• Alex Freeland has hit the Runs Under in 9 of his last 10 games (+7.85 Units / 41% ROI)

And here are some favorite MLB player prop bets for Giants players for Wednesday‘s game, looking at profitable historical betting trends:

Best Giants Player Prop Best Bets Today:

• Matt Chapman has hit the Walks Under in 17 of his last 20 games (+12.10 Units / 34% ROI)
• Heliot Ramos has hit the Home Runs Over in 2 of his last 4 games (+11.10 Units / 278% ROI)
• Matt Chapman has hit the Singles Over in 14 of his last 20 games (+9.50 Units / 46% ROI)
• Heliot Ramos has hit the Total Bases Over in 7 of his last 8 games (+7.55 Units / 78% ROI)
• Patrick Bailey has hit the Hits Runs and RBIs Under in 14 of his last 20 games (+7.55 Units / 29% ROI)

Dodgers Best Bets Today:

• The Los Angeles Dodgers have hit the Moneyline in 34 of their last 45 games (+12.80 Units / 15% ROI)
• The Los Angeles Dodgers have hit the 1st Five Innings (F5) Moneyline in 18 of their last 30 away games (+9.65 Units / 20% ROI)
• The Los Angeles Dodgers have covered the Run Line in 15 of their last 23 away games (+7.35 Units / 25% ROI)
• The Los Angeles Dodgers have hit the Team Total Over in 15 of their last 24 away games (+6.05 Units / 22% ROI)
• The Los Angeles Dodgers have hit the Game Total Under in 20 of their last 35 games (+4.60 Units / 12% ROI)

Giants Best Bets Today:

• The San Francisco Giants have hit the 1st Five Innings (F5) Team Total Under in 29 of their last 50 games at home (+6.85 Units / 12% ROI)
• The San Francisco Giants have hit the Team Total Over in 19 of their last 30 games at home (+6.55 Units / 18% ROI)
• The San Francisco Giants have covered the 1st Five Innings (F5) Run Line in 11 of their last 16 games at home (+4.65 Units / 22% ROI)
• The San Francisco Giants have hit the 1st Five Innings (F5) Moneyline in 15 of their last 30 games at home (+4.35 Units / 11% ROI)
• The San Francisco Giants have hit the Game Total Over in 16 of their last 30 games at home (+3.90 Units / 12% ROI)

Dodgers Against the Spread (ATS) Record

Against the spread this season, the Dodgers are 12-11 against the Run Line (+0.1 Units / 0.35% ROI).

• 16-7 when betting on the Moneyline for +1.75 Units / 3.54% ROI
• 11-12 when betting on the total runs Over for -2.35 Units / -9.23% ROI
• 12-11 when betting on the total runs Under for -0.1 Units / -0.4% ROI

Giants Against the Spread (ATS) Record

Against the spread this season, the Giants are 8-14 against the Run Line (-10.95 Units / -34.22% ROI).

• 10-13 when betting on the Moneyline for -3.15 Units / -12.55% ROI
• 10-10 when betting on the total runs Over for -0.85 Units / -3.37% ROI
• 10-10 when betting on the total runs Under for -1.05 Units / -4.13% ROI

Giants vs Dodgers Home Run Prop Bets Today

Giants vs Dodgers Total Hits Prop Bets Today

Giants vs Dodgers Strikeout Prop Bets Today

Dodgers Keys to the Game vs. the Giants

The Dodgers are 2-6 (.250) when trailing entering the 8th inning this season — tied for 3rd best in MLB; League Avg: .105.

The Dodgers are 7-4 (.636) on the road this season — tied for 4th best in MLB; League Avg: .462.

The Dodgers were 93-69 (.574) in the 2025 season — 5th best in MLB; League Avg: .500.

The Dodgers are just 0-7 (.000) when trailing entering the 9th inning this season — tied for lowest in MLB; League Avg: .050.

Giants Keys to the Game vs. the Dodgers

The Giants were just 65-6 (.915) when leading entering the 9th inning in the 2025 season — 3rd lowest in MLB; League Avg: .956.

The Giants are just 0-11 (.000) when trailing entering the 7th inning this season — tied for lowest in MLB; League Avg: .134.

The Giants are just 0-12 (.000) when trailing entering the 8th inning this season — tied for lowest in MLB; League Avg: .105.

The Giants were 11-65 (.145) when trailing entering the 8th inning in the 2025 season — 2nd best in MLB; League Avg: .090.

Dodgers Hitting Stats & Trends

Dodgers hitters have an OPS of .915 (472 PA’s) on the road this season — best in MLB.

Dodgers hitters are slugging .533 on the road this season — best in MLB.

Dodgers hitters have an OPS of .856 (899 PA’s) this season — best in MLB.

Dodgers hitters have an OPS of .858 (661 PA’s) against RHP this season — best in MLB.

Giants Hitting Stats & Trends

Giants hitters had an OPS of just .631 (1,623 PA’s) against LHP in the 2025 season — lowest in MLB.

The Giants batted just .214 against LHP in the 2025 season — lowest in MLB.

Giants hitters have drawn walks in 6% of their PA’s against LHP this season — tied for lowest in MLB.

Giants hitters have an OBP of just .284 (1,876 PA’s) against LHP since the 2025 season — lowest in MLB.

Dodgers Pitching Stats & Trends

Dodgers pitchers had a strikeout rate of 25% in the 2025 season — 2nd best in MLB.

Dodgers pitchers had a strikeout rate of 46% with two-strikes in the 2025 season — 3rd best in MLB.

Dodgers pitchers have walked 9% of batters since the 2025 season — tied for 4th highest in MLB.

Dodgers pitchers have a strikeout rate of 25% since the 2025 season — 2nd best in MLB.

Giants Pitching Stats & Trends

Opponents have a groundball rate of 48% against Giants pitchers this season — highest in MLB.

Opponents had a groundball rate of 49% against Giants pitchers in the 2024 season — highest in MLB.

Giants pitchers had a strikeout rate of just 19% with runners in scoring position in the 2025 season — 3rd lowest in MLB.

Opponents had a groundball rate of 46% against Giants pitchers in the 2025 season — 3rd highest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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