• The Cardinals are -170 favorites vs the Giants
• Giants vs Cardinals Over / Under today: 8 Runs
• Giants / Cardinals TV Channel: NSBA | CATV

The San Francisco Giants (+140) visit Busch Stadium to take on the St. Louis Cardinals (-170) on September 15, 2026. First pitch is scheduled for 7:45 pm in St. Louis, MO.

This season, the Giants are 62-89 against the spread (ATS), while the Cardinals are 83-65 ATS.

Giants vs Cardinals Starting Pitchers Today:

• Giants starting pitcher: Blade Tidwell 0-2, 4.86 ERA
• Cardinals starting pitcher: Andre Pallante 12-6, 3.47 ERA

Giants vs. Cardinals Odds, Run Line, Over/Under & Moneyline

Giants vs Cardinals Prediction for Today’s Game

Based on recent trends the model predicts the Cardinals will win Tuesday‘s MLB game with 55.6% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

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We’ve highlighted some favorite MLB player prop bets for Giants players for Tuesday‘s game, looking at profitable historical betting trends:

Best Giants Player Prop Bets Today:

• Jung Hoo Lee has hit the Total Bases Under in 21 of his last 25 games (+14.60 Units / 34% ROI)
• Bryce Eldridge has hit the Hits Over in 21 of his last 25 games (+14.10 Units / 32% ROI)
• Jonah Cox has hit the Home Runs Over in 2 of his last 7 away games (+14.00 Units / 200% ROI)
• Jung Hoo Lee has hit the Runs Under in 21 of his last 25 games (+13.05 Units / 24% ROI)
• Bryce Eldridge has hit the Hits Runs and RBIs Over in 18 of his last 25 games (+11.95 Units / 45% ROI)

And here are some favorite MLB player prop bets for Cardinals players for Tuesday‘s game, looking at profitable historical betting trends:

Best Cardinals Player Prop Best Bets Today:

• Nathan Church has hit the Hits Over in 17 of his last 20 games (+12.45 Units / 37% ROI)
• Leonardo Bernal has hit the Home Runs Over in 2 of his last 5 games (+12.00 Units / 240% ROI)
• Nathan Church has hit the Singles Over in 18 of his last 25 games (+12.00 Units / 45% ROI)
• Thomas Saggese has hit the Total Bases Over in 13 of his last 15 games (+10.75 Units / 55% ROI)
• Alec Burleson has hit the RBIs Over in 12 of his last 20 games (+10.60 Units / 53% ROI)

Giants Best Bets Today:

• The San Francisco Giants have hit the 1st Five Innings (F5) Team Total Over in 21 of their last 25 games (+16.60 Units / 53% ROI)
• The San Francisco Giants have hit the Team Total Over in 16 of their last 22 games (+9.35 Units / 37% ROI)
• The San Francisco Giants have hit the Game Total Over in 10 of their last 15 games (+5.45 Units / 33% ROI)
• The San Francisco Giants have hit the 1st Five Innings (F5) Moneyline in 24 of their last 50 games (+5.25 Units / 9% ROI)
• The San Francisco Giants have covered the 1st Five Innings (F5) Run Line in 20 of their last 35 games (+3.50 Units / 9% ROI)

Cardinals Best Bets Today:

• The St. Louis Cardinals have hit the Game Total Over in 24 of their last 35 games (+14.05 Units / 36% ROI)
• The St. Louis Cardinals have hit the 1st Five Innings (F5) Moneyline in 23 of their last 40 games (+13.40 Units / 29% ROI)
• The St. Louis Cardinals have hit the Team Total Over in 24 of their last 35 games (+10.85 Units / 25% ROI)
• The St. Louis Cardinals have covered the 1st Five Innings (F5) Run Line in 26 of their last 40 games (+9.95 Units / 21% ROI)
• The St. Louis Cardinals have hit the 1st Five Innings (F5) Team Total Over in 16 of their last 24 games (+8.80 Units / 31% ROI)

Giants Against the Spread (ATS) Record

Against the spread this season, the Giants are 74-75 against the Run Line (-20.1 Units / -9.64% ROI).

• 62-89 when betting on the Moneyline for -22.35 Units / -13.45% ROI
• 71-67 when betting on the total runs Over for -2.85 Units / -1.71% ROI
• 67-71 when betting on the total runs Under for -10.85 Units / -6.55% ROI

Cardinals Against the Spread (ATS) Record

Against the spread this season, the Cardinals are 83-65 against the Run Line (+3.35 Units / 1.6% ROI).

• 75-76 when betting on the Moneyline for +5.65 Units / 3.43% ROI
• 69-75 when betting on the total runs Over for -14.05 Units / -8.43% ROI
• 75-69 when betting on the total runs Under for -0.95 Units / -0.57% ROI

Giants Keys to the Game vs. the Cardinals

The Giants are just 2-66 (.029) when trailing entering the 7th inning this season — tied for lowest in MLB.

The Giants are just 19-31 (.380) vs bottom 10 scoring offenses this season Today, they face the Cardinals (11th in runs scored).

The Giants are just 6-28 (.176) when allowing 2 or more home runs this season — 2nd lowest in MLB.

The Giants are just 26-50 (.342) on the road this season — 2nd lowest in MLB.

Cardinals Keys to the Game vs. the Giants

The Cardinals are just 28-17 (.622) when they’ve had 10 or more hits this season — 2nd lowest in MLB.

The Cardinals are just 6-14 (.300) when tied entering the 8th inning this season — 3rd lowest in MLB.

The Cardinals are just 66-33 (.667) when they’ve had 10 or more hits since the 2025 season — tied for 2nd lowest in MLB.

The Cardinals are 57-168 (.253) when allowing 5 or more runs since the 2024 season — 3rd best in MLB.

Giants Hitting Stats & Trends

The Giants are batting .256 with two outs this season — 2nd best in MLB.

Giants hitters have an OBP of just .291 (1,655 PA’s) against LHP this season — lowest in MLB.

Giants hitters have drawn walks in 7% of their PA’s against LHP this season — lowest in MLB.

The Giants are batting just .233 against LHP this season — tied for 5th lowest in MLB.

Cardinals Hitting Stats & Trends

Cardinals hitters have struck out in just 19% of their PA’s against LHP this season — 3rd best in MLB.

Cardinals hitters have an OBP of .359 (669 PA’s) when facing the starting pitcher for the 3rd time in a game this season — 3rd best in MLB.

Cardinals hitters have an OPS of just .667 (2,775 PA’s) at home this season — 2nd lowest in MLB.

The Cardinals have scored 5.25 runs per game (394/75) on the road this season — 3rd best in MLB.

Giants Pitching Stats & Trends

Opponents have a groundball rate of 46% against Giants pitchers this season — highest in MLB.

The Giants have won just 5% of road games in which their opponents scored first this season — lowest in MLB.

Giants pitchers have thrown at least two strikes in their first three pitches to 59% of opposing batters this season — lowest in MLB.

Opponents have a miss rate of just 23% against Giants pitchers this season — 5th lowest in MLB.

Cardinals Pitching Stats & Trends

Opponents have a groundball rate of 45% against Cardinals pitchers this season — tied for 4th highest in MLB.

The Cardinals pitchers have allowed their opponents to score first in just 36% of their games on the road this season — lowest in MLB.

The Cardinals pitchers have allowed their opponents to score first in just 45% of their games this season — tied for 3rd lowest in MLB.

Cardinals pitchers have 182 three-pitch strikeouts this season — 4th fewest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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