• The Cardinals are -170 favorites vs the Giants
• Giants vs Cardinals Over / Under today: 8 Runs
• Giants / Cardinals TV Channel: NSBA | CATV

The San Francisco Giants (+140) visit Busch Stadium to take on the St. Louis Cardinals (-170) on September 16, 2026. First pitch is scheduled for 1:15 pm in St. Louis, MO.

This season, the Giants are 63-89 against the spread (ATS), while the Cardinals are 83-66 ATS.

Giants vs Cardinals Starting Pitchers Today:

• Giants starting pitcher: Anthony Molina 3-1, 5.24 ERA
• Cardinals starting pitcher: Matthew Liberatore 5-14, 5.54 ERA

Giants vs. Cardinals Odds, Run Line, Over/Under & Moneyline

Giants vs Cardinals Prediction for Today’s Game

Based on recent trends the model predicts the Cardinals will win Wednesday‘s MLB game with 56.9% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

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We’ve highlighted some favorite MLB player prop bets for Giants players for Wednesday‘s game, looking at profitable historical betting trends:

Best Giants Player Prop Bets Today:

• Bryce Eldridge has hit the Total Bases Over in 19 of his last 25 games (+16.50 Units / 55% ROI)
• Bryce Eldridge has hit the Hits Over in 21 of his last 25 games (+14.10 Units / 32% ROI)
• Jonah Cox has hit the Home Runs Over in 2 of his last 8 away games (+13.00 Units / 162% ROI)
• Bryce Eldridge has hit the Hits Runs and RBIs Over in 18 of his last 25 games (+11.95 Units / 45% ROI)
• Jonah Cox has hit the Singles Over in 15 of his last 20 games (+11.30 Units / 54% ROI)

And here are some favorite MLB player prop bets for Cardinals players for Wednesday‘s game, looking at profitable historical betting trends:

Best Cardinals Player Prop Best Bets Today:

• Thomas Saggese has hit the Hits Over in 17 of his last 20 games (+12.90 Units / 40% ROI)
• Bryan Torres has hit the Singles Over in 18 of his last 25 games (+12.05 Units / 43% ROI)
• Leonardo Bernal has hit the Home Runs Over in 2 of his last 6 games (+11.00 Units / 183% ROI)
• Alec Burleson has hit the RBIs Over in 12 of his last 20 games (+10.45 Units / 52% ROI)
• Thomas Saggese has hit the Total Bases Over in 15 of his last 20 games (+9.25 Units / 35% ROI)

Giants Best Bets Today:

• The San Francisco Giants have hit the 1st Five Innings (F5) Team Total Over in 24 of their last 30 games (+17.70 Units / 48% ROI)
• The San Francisco Giants have hit the Team Total Over in 17 of their last 23 games (+10.35 Units / 39% ROI)
• The San Francisco Giants have hit the Game Total Over in 18 of their last 30 games (+7.00 Units / 21% ROI)
• The San Francisco Giants have hit the 1st Five Innings (F5) Moneyline in 25 of their last 50 games (+6.60 Units / 12% ROI)
• The San Francisco Giants have covered the 1st Five Innings (F5) Run Line in 23 of their last 40 games (+4.45 Units / 10% ROI)

Cardinals Best Bets Today:

• The St. Louis Cardinals have hit the Game Total Over in 22 of their last 30 games (+14.25 Units / 43% ROI)
• The St. Louis Cardinals have hit the 1st Five Innings (F5) Moneyline in 24 of their last 45 games (+12.10 Units / 23% ROI)
• The St. Louis Cardinals have hit the Team Total Over in 23 of their last 35 games (+8.85 Units / 21% ROI)
• The St. Louis Cardinals have hit the 1st Five Innings (F5) Team Total Over in 24 of their last 40 games (+8.55 Units / 18% ROI)
• The St. Louis Cardinals have covered the 1st Five Innings (F5) Run Line in 25 of their last 40 games (+7.75 Units / 17% ROI)

Giants Against the Spread (ATS) Record

Against the spread this season, the Giants are 75-75 against the Run Line (-19.1 Units / -9.1% ROI).

• 63-89 when betting on the Moneyline for -20.8 Units / -12.44% ROI
• 72-67 when betting on the total runs Over for -1.85 Units / -1.1% ROI
• 67-72 when betting on the total runs Under for -11.95 Units / -7.17% ROI

Cardinals Against the Spread (ATS) Record

Against the spread this season, the Cardinals are 83-66 against the Run Line (+2.35 Units / 1.12% ROI).

• 75-77 when betting on the Moneyline for +3.9 Units / 2.34% ROI
• 70-75 when betting on the total runs Over for -13.05 Units / -7.78% ROI
• 75-70 when betting on the total runs Under for -2.05 Units / -1.23% ROI

Giants Keys to the Game vs. the Cardinals

The Giants are just 2-66 (.029) when trailing entering the 7th inning this season — tied for lowest in MLB.

The Giants are just 11-64 (.147) when allowing 5 or more runs this season — 3rd lowest in MLB.

The Giants are just 19-31 (.380) vs bottom 10 scoring offenses this season Today, they face the Cardinals (12th in runs scored).

The Giants are just 57-9 (.864) when leading entering the 9th inning this season — 2nd lowest in MLB.

Cardinals Keys to the Game vs. the Giants

The Cardinals are just 28-17 (.622) when they’ve had 10 or more hits this season — 2nd lowest in MLB.

The Cardinals are just 6-14 (.300) when tied entering the 8th inning this season — 3rd lowest in MLB.

The Cardinals are just 66-33 (.667) when they’ve had 10 or more hits since the 2025 season — tied for 2nd lowest in MLB.

The Cardinals are just 13-25 (.342) when tied entering the 8th inning since the 2025 season — lowest in MLB.

Giants Hitting Stats & Trends

Giants hitters have drawn walks in 7% of their PA’s this season — lowest in MLB.

30% of Giants hitters strikeouts have come on 95+ MPH fastballs this season — highest in MLB.

The Giants are batting .257 with two outs this season — 2nd best in MLB.

Giants hitters have an OBP of just .235 (3,009 PA’s) with two-strikes this season — 2nd lowest in MLB.

Cardinals Hitting Stats & Trends

Cardinals hitters have struck out in just 19% of their PA’s against LHP this season — 3rd best in MLB.

Cardinals hitters have an OBP of .357 (676 PA’s) when facing the starting pitcher for the 3rd time in a game this season — 3rd best in MLB.

Cardinals hitters have an OBP of just .305 (2,810 PA’s) at home this season — 2nd lowest in MLB.

The Cardinals have scored 5.25 runs per game (394/75) on the road this season — 3rd best in MLB.

Giants Pitching Stats & Trends

Opponents have a groundball rate of 46% against Giants pitchers this season — highest in MLB.

Giants pitchers have a strikeout rate of just 39% with two-strikes this season — 5th lowest in MLB.

Giants pitchers have a strikeout rate of just 20% this season — 4th lowest in MLB.

The Giants have won just 21% of games in which their opponents scored first this season — 2nd lowest in MLB.

Cardinals Pitching Stats & Trends

The Cardinals pitchers have allowed an average Exit Velocity of 89.4 MPH this season (3,950 balls in play) — 3rd highest in MLB

The Cardinals pitchers have allowed their opponents to score first in just 36% of their games on the road this season — lowest in MLB.

Opponents have a groundball rate of 45% against Cardinals pitchers this season — tied for 3rd highest in MLB.

Cardinals pitchers have 182 three-pitch strikeouts this season — 4th fewest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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