Giants vs Diamondbacks Prediction, Odds & Player Prop Bets Today – MLB, Sep 25

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MLB betting odds, predictions and betting odds for today's games
(AP Photo)
BetMGM Betting @BETMGM Sep 25, 2022, 11:48 AM
  • The Diamondbacks (71-82) are -120 favorites vs the Giants (74-78)
  • Giants starting pitcher: Scott Alexander (0-0), 1.38 ERA
  • Diamondbacks starting pitcher: Drey Jameson (2-0), 1.38 ERA
  • Watch the game on BSAZ

The San Francisco Giants (+100) visit Chase Field to take on the Arizona Diamondbacks (-120) on Sunday, September 25, 2022. First pitch is scheduled for 3:40pm EDT in Phoenix.

The Diamondbacks are betting favorites in this MLB matchup, with the run line sitting at 1.5.

The Giants vs Diamondbacks Over/Under is 8.5 total runs for the game.

So far this season, the Giants are 74-78 against the spread (ATS), while the Diamondbacks are 89-64 ATS.

Giants vs. Diamondbacks Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Giants+1.5O 8.5 -110+100
Diamondbacks 1.5U 8.5 -110-120

Giants vs Diamondbacks Prediction for Today’s Game

Based on recent trends the model predicts the Giants will win Sunday‘s matchup with 51.3% confidence.

This prediction factors in starting pitchers, recent team and player hitting performances, the last 5 games for both the Giants and Diamondbacks and up-to-date player injuries.


Looking for a risk-free bet up to $1,000? Bet now on Diamondbacks vs Giants and all MLB games with BetMGM


Best Giants Player Prop Bets Today

We’ve highlighted some favorite MLB player prop bets for Giants players for Sunday‘s game, looking at profitable historical betting trends:

  • Wilmer Flores has hit the Hits Under in 15 of his last 20 away games (+11.95 Units / 36% ROI)
  • Jason Vosler has hit the Total Bases Over in 14 of his last 17 games (+11.75 Units / 53% ROI)
  • Wilmer Flores has hit the Runs Under in 17 of his last 21 away games (+11.70 Units / 39% ROI)
  • Jason Vosler has hit the Hits Over in 14 of his last 17 games (+11.25 Units / 46% ROI)
  • Wilmer Flores has hit the Total Bases Under in 15 of his last 18 away games (+11.20 Units / 42% ROI)

Best Diamondbacks Player Prop Best Bets Today

And here are some favorite MLB player prop bets for Diamondbacks players for Sunday‘s game, looking at profitable historical betting trends:

  • Christian Walker has hit the Hits Over in 34 of his last 47 games (+13.75 Units / 15% ROI)
  • Merrill Kelly has hit the Pitching Outs Over in 16 of his last 20 games (+12.75 Units / 52% ROI)
  • Christian Walker has hit the Total Bases Under in 38 of his last 55 games at home (+12.15 Units / 14% ROI)
  • Christian Walker has hit the Singles Over in 27 of his last 44 games (+11.70 Units / 25% ROI)
  • Alek Thomas has hit the Total Bases Under in 16 of his last 21 games at home (+11.10 Units / 39% ROI)
  • The San Francisco Giants have hit the Game Total Under in 12 of their last 15 games (+8.65 Units / 53% ROI)
  • The San Francisco Giants have hit the Moneyline in 7 of their last 8 away games (+6.00 Units / 62% ROI)
  • The San Francisco Giants have covered the Run Line in 6 of their last 8 away games (+4.45 Units / 46% ROI)
  • The San Francisco Giants have hit the Team Total Over in 4 of their last 6 games (+1.70 Units / 25% ROI)
  • The San Francisco Giants have covered the 1st Five Innings (F5) Run Line in 5 of their last 8 away games (+1.50 Units / 15% ROI)
  • The Arizona Diamondbacks have covered the 1st Five Innings (F5) Run Line in 28 of their last 39 games at home (+17.35 Units / 38% ROI)
  • The Arizona Diamondbacks have covered the Run Line in 43 of their last 76 games at home (+12.95 Units / 15% ROI)
  • The Arizona Diamondbacks have hit the Team Total Over in 27 of their last 42 games at home (+10.75 Units / 22% ROI)
  • The Arizona Diamondbacks have hit the Game Total Under in 10 of their last 13 games at home (+6.80 Units / 48% ROI)
  • The Arizona Diamondbacks have hit the Moneyline in 23 of their last 42 games at home (+4.75 Units / 9% ROI)

Giants Against the Spread (ATS) Record

Against the spread this MLB season, the Giants have gone 71-81 against the Run Line (-18.3 Units / -9.7% ROI).

  • 74-78 when betting on the Moneyline for -24.9 Units / -11.44% ROI
  • 69-74 when betting on the total runs Over for -12.4 Units / -7.45% ROI
  • 74-69 when betting on the total runs Under for -2.7 Units / -1.6% ROI

Diamondbacks Against the Spread (ATS) Record

Against the spread this MLB season, the Giants have gone 89-64 against the Run Line (+22.05 Units / 11.35% ROI).

  • 71-82 when betting on the Moneyline for +0.55 Units / 0.32% ROI
  • 68-80 when betting on the total runs Over for -19.75 Units / -11.77% ROI
  • 80-68 when betting on the total runs Under for +4.3 Units / 2.54% ROI

Right-handed hitters have a groundball rate of 78% (14/18) against Scott Alexander this month (9 games) — highest among qualified RPs in MLB; League Avg: 45% — 100th Percentile.

Scott Alexander has not allowed a walk in his last 61 PAs against a LHH dating back to April 1st, 2021 — Dylan Lee has the longest active streak at 70.

Opponents have a groundball rate of 71% (20/28) against Scott Alexander this month (10 games) — 9th highest among qualified RPs in MLB; League Avg: 45% — 96th Percentile.

Scott Alexander has allowed an OBP of just .133 (15 PA’s) vs left-handed batters this month (9 games) — tied for 5th best among qualified RPs in MLB; League Avg: .314 — 95th Percentile.

Drey Jameson: Diamondbacks Starting Pitcher Stats & Trends

Drey Jameson has allowed an OBP of just .038 (26 PA’s) with two-strikes — best in MLB over the last two weeks; League Avg: .220 — 100th Percentile.

Opponents are hitless in 25 AB’s against Drey Jameson with two-strikes — best in MLB over the last two weeks; League Avg: .153 — 100th Percentile.

Opponents have a groundball rate of 60% (21/35) against Drey Jameson — 5th highest in MLB over the last two weeks; League Avg: 44% — 94th Percentile.

Drey Jameson has allowed an OPS of just .038 (26 PA’s) with two-strikes — best in MLB over the last two weeks; League Avg: .455 — 100th Percentile.

Giants Keys to the Game vs. the Diamondbacks

The Giants are 49-9 (.845) when scoring 5 or more runs this season — 10th best in MLB; League Avg: .802.

The Giants are just 25-69 (.266) when scoring 4 or fewer runs this season — 10th lowest in MLB; League Avg: .294.

The Giants are 7-63 (.100) when trailing entering the 8th inning this season — 10th best in MLB; League Avg: .084.

The Giants are 23-4 (.852) when totaling 5 or more extra base hits this season — 10th best in MLB; League Avg: .804.

Diamondbacks Keys to the Game vs. the Giants

The Diamondbacks are just 110-34 (.764) when leading entering the 7th inning since the 2020 season — lowest in MLB; League Avg: .875.

The Diamondbacks are just 121-22 (.846) when leading entering the 8th inning since the 2020 season — lowest in MLB; League Avg: .915.

The Diamondbacks are just 8-15 (.348) when tied entering the 7th inning this season — 3rd lowest in MLB; League Avg: .500.

The Diamondbacks are just 56-10 (.848) when leading entering the 8th inning this season — 2nd lowest in MLB; League Avg: .916.

Giants hitters are slugging just .377 when facing the starting pitcher for the 3rd time in a game this season — 2nd lowest in MLB; League Avg: .447.

The Giants are batting just .222 when facing the starting pitcher for the 3rd time in a game this season — lowest in MLB; League Avg: .265.

The Giants are batting .360 on the first pitch of at-bats this season — 4th best in MLB; League Avg: .335.

Giants hitters have drawn 339 walks in 3,564 PA’s (10%) against LHP since the start of last season — tied for 3rd best in MLB; League Avg: 9%.

Diamondbacks hitters have put just 34% of balls in play to the left side of the field since the start of 2020 — lowest in MLB; League Avg: 38%.

The Diamondbacks are batting just .219 with two outs since the start of last season — 2nd lowest in MLB; League Avg: .233.

The Diamondbacks are batting just .232 when facing the starting pitcher for the 3rd time in a game this season — 2nd lowest in MLB; League Avg: .265.

Diamondbacks hitters have chased 26% of pitches out of the zone against LHP this season — 2nd lowest in MLB; League Avg: 29%.

Opponents have a groundball rate of 48% against Giants pitchers this season — highest in MLB; League Avg: 43%.

Giants pitchers have walked 827 of 11,664 batters (7%) since the start of last season — 2nd best in MLB; League Avg: 8%.

Giants pitchers have walked 173 of 2,803 batters (6%) when facing the leadoff batter in the inning since the start of last season — 3rd best in MLB; League Avg: 8%.

Opponents have a groundball rate of 47% against Giants pitchers since the start of last season — highest in MLB; League Avg: 43%.

Diamondbacks pitchers have a strikeout rate of just 18% in close and late situations this season — lowest in MLB; League Avg: 25%.

Opponents have a groundball rate of just 36% against Diamondbacks pitchers this month (23 games) — lowest in MLB; League Avg: 43%.

Diamondbacks pitchers have a strikeout rate of just 19% in close and late situations since the start of last season — lowest in MLB; League Avg: 25%.

Opponents have a groundball rate of just 34% against Diamondbacks pitchers over the last 14 days (15 games) — lowest in MLB; League Avg: 43%.

Diamondbacks vs. Giants Injuries Tonight That May Affect Prop Bets 

  • Tyler Gilbert (Diamondbacks): Elbow, D60
  • Yonny Hernandez (Diamondbacks): Calf, D60
  • Keynan Middleton (Diamondbacks): Toe, D15
  • Ryne Nelson (Diamondbacks): Arm, D15
  • Humberto Castellanos (Diamondbacks): Elbow, D60
  • Nicholas Ahmed (Diamondbacks): Shoulder, D60
  • Kyle Nelson (Diamondbacks): Elbow, D15
  • Gregory Santos (Giants): Groin, D60
  • Carlos Rodón (Giants): Hand, Day-to-Day
  • Thomas Szapucki (Giants): Hip, Day-to-Day
  • Brandon Belt (Giants): Knee, D60
  • Donovan Walton (Giants): Shoulder, D60
  • Robert Wood (Giants): Shoulder, D15
  • José Álvarez (Giants): Elbow, D60
  • Thomas La Stella (Giants): Neck, D10
  • Mauricio Llovera (Giants): Hip, D60
  • Colton Welker (Giants): Shoulder, D60
  • Samuel Long (Giants): Oblique, D60
  • Samuel Delaplane (Giants): Forearm, D60
  • Anthony DeSclafani (Giants): Ankle, D60
  • Luis González (Giants): Back, D10

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Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.