• The Giants are -145 favorites vs the Padres
• Giants vs Padres Over / Under today: 7.5 Runs
• Giants / Padres TV Channel: NSBA | PDTV

The San Francisco Giants (-145) visit Petco Park to take on the San Diego Padres (+120) on March 31, 2026. First pitch is scheduled for 9:40 pm in San Diego, CA.

This season, the Giants are 1-3 against the spread (ATS), while the Padres are 1-2 ATS.

Giants vs Padres Starting Pitchers Today:

• Giants starting pitcher: Logan Webb 0-1, 10.81 ERA
• Padres starting pitcher: German Marquez 0-0, 0.00 ERA

Giants vs. Padres Odds, Run Line, Over/Under & Moneyline

Giants vs Padres Prediction for Today’s Game

Based on recent trends the model predicts the Giants will win Tuesday‘s MLB game with 51.0% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Giants vs Padres and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Giants players for Tuesday‘s game, looking at profitable historical betting trends:

Best Giants Player Prop Bets Today:

• Heliot Ramos has hit the Home Runs Over in 3 of his last 10 games (+14.30 Units / 143% ROI)
• Willy Adames has hit the Walks Over in 12 of his last 20 away games (+11.30 Units / 56% ROI)
• Matt Chapman has hit the Total Bases Under in 15 of his last 20 games (+8.80 Units / 32% ROI)
• Harrison Bader has hit the Runs Over in 10 of his last 15 away games (+8.75 Units / 58% ROI)
• Luis Arraez has hit the Singles Over in 16 of his last 20 games (+8.30 Units / 21% ROI)

And here are some favorite MLB player prop bets for Padres players for Tuesday‘s game, looking at profitable historical betting trends:

Best Padres Player Prop Best Bets Today:

• Gavin Sheets has hit the Singles Under in 17 of his last 20 games at home (+12.25 Units / 39% ROI)
• Jackson Merrill has hit the Total Bases Over in 16 of his last 25 games (+10.35 Units / 41% ROI)
• Gavin Sheets has hit the Hits Under in 13 of his last 20 games at home (+10.20 Units / 51% ROI)
• Gavin Sheets has hit the Hits Runs and RBIs Under in 18 of his last 25 games (+10.00 Units / 32% ROI)
• German Marquez has hit the Strikeouts Under in 17 of his last 25 games (+8.20 Units / 27% ROI)

Giants Best Bets Today:

• The San Francisco Giants have hit the Team Total Over in 24 of their last 35 games (+11.95 Units / 30% ROI)
• The San Francisco Giants have covered the Run Line in 23 of their last 34 games (+10.65 Units / 23% ROI)
• The San Francisco Giants have hit the 1st Five Innings (F5) Team Total Over in 23 of their last 35 games (+10.10 Units / 24% ROI)
• The San Francisco Giants have covered the 1st Five Innings (F5) Run Line in 20 of their last 31 games (+7.50 Units / 20% ROI)
• The San Francisco Giants have hit the Moneyline in 20 of their last 33 games (+6.45 Units / 14% ROI)

Padres Best Bets Today:

• The San Diego Padres have hit the Game Total Under in 86 of their last 151 games (+17.30 Units / 10% ROI)
• The San Diego Padres have covered the Run Line in 42 of their last 77 games at home (+11.95 Units / 13% ROI)
• The San Diego Padres have hit the 1st Five Innings (F5) Team Total Under in 70 of their last 123 games (+10.55 Units / 7% ROI)
• The San Diego Padres have covered the 1st Five Innings (F5) Run Line in 21 of their last 32 games at home (+9.50 Units / 26% ROI)
• The San Diego Padres have hit the Team Total Over in 23 of their last 36 games at home (+7.95 Units / 18% ROI)

Giants Against the Spread (ATS) Record

Against the spread this season, the Giants are 0-3 against the Run Line (-4.65 Units / -82.3% ROI).

• 1-3 when betting on the Moneyline for -2 Units / -49.38% ROI
• 0-3 when betting on the total runs Over for -3.3 Units / -75% ROI
• 3-0 when betting on the total runs Under for +3 Units / 68.18% ROI

Padres Against the Spread (ATS) Record

Against the spread this season, the Padres are 1-2 against the Run Line (-1.65 Units / -27.97% ROI).

• 1-3 when betting on the Moneyline for -2.5 Units / -54.35% ROI
• 1-3 when betting on the total runs Over for -2.3 Units / -52.27% ROI
• 3-1 when betting on the total runs Under for +1.9 Units / 43.18% ROI

Giants Keys to the Game vs. the Padres

The Giants were just 65-6 (.915) when leading entering the 9th inning in the 2025 season — 3rd lowest in MLB; League Avg: .956.

The Giants were 12-60 (.167) when trailing entering the 7th inning in the 2025 season — tied for 4th best in MLB; League Avg: .124.

The Giants were 11-65 (.145) when trailing entering the 8th inning in the 2025 season — 2nd best in MLB; League Avg: .090.

The Giants are just 132-9 (.936) when leading entering the 9th inning since the 2024 season — tied for 4th lowest in MLB; League Avg: .953.

Padres Keys to the Game vs. the Giants

The Padres were 25-14 (.641) vs the top 10 runs allowed teams in the 2025 season Today, they face Giants (16th in runs allowed).

The Padres were 11-55 (.167) when trailing entering the 7th inning in the 2025 season — tied for 4th best in MLB; League Avg: .124.

The Padres were 52-29 (.642) at home in the 2025 season — tied for 3rd best in MLB; League Avg: .542.

The Padres were 32-17 (.653) vs bottom 10 scoring offenses in the 2025 season Today, they face the Giants (30th in runs scored).

Giants Hitting Stats & Trends

The Giants batted just .214 against LHP in the 2025 season — lowest in MLB.

Giants hitters have an OPS of just .388 (99 PA’s) over the last 14 days — lowest in MLB.

Giants hitters have an OPS of just .388 (99 PA’s) over the past seven days (3 games) — lowest in MLB.

Giants hitters had an OBP of just .280 (1,623 PA’s) against LHP in the 2025 season — lowest in MLB.

Padres Hitting Stats & Trends

Padres hitters struck out in just 18% of their PA’s against LHP in the 2025 season — best in MLB.

Padres hitters struck out in just 19% of their PA’s in the 2025 season — 3rd best in MLB.

Padres hitters have struck out in just 18% of their PA’s against LHP since the 2024 season — best in MLB.

The Padres batted .192 with two-strikes in the 2025 season — 2nd best in MLB.

Giants Pitching Stats & Trends

Opponents have a groundball rate of 47% against Giants pitchers since the 2024 season — highest in MLB.

Opponents had a groundball rate of 46% against Giants pitchers in the 2025 season — 3rd highest in MLB.

Opponents have a groundball rate of 48% against Giants pitchers since the 2023 season — highest in MLB.

The Giants pitchers allowed their opponents to score first in just 38% of their games on the road in the 2025 season — 2nd lowest in MLB.

Padres Pitching Stats & Trends

Padres pitchers had a strikeout rate of 24% in the 2025 season — tied for 4th best in MLB.

The Padres pitchers allowed division opponents to score first in just 35% of their games in the 2025 season — tied for lowest in MLB.

Padres pitchers allowed innings of 3+ runs in 4% of innings played in the 2025 season — lowest in MLB.

The Padres pitchers have allowed an average Exit Velocity of just 88.4 MPH since the 2023 season (11,829 balls in play) — best in MLB

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

Bet now on Giants vs Padres and all games with BetMGM

Bet on MLB Odds at BetMGM

Sportsbook promos are always available at BetMGM. For new customers, check out the sportsbook welcome offer and BetMGM Refer a Friend. For existing customers, there are Odds Boosts, Parlay Boosts, contests and more.