- Get betting predictions and analysis for Giants vs. Reds on Opening Day.
- First pitch is scheduled for 4:10 p.m. ET at Great American Ball Park.
- My Giants vs. Reds prediction is to back Cincinnati at home.
One of the more underrated matchups for MLB’s 14-game slate on Opening Day is a battle between the San Francisco Giants and Cincinnati Reds at Great American Ball Park. First pitch is 4:10 p.m. ET on Thursday.
Both teams made leadership changes in the offseason, with the Reds bringing Terry Francona out of retirement to be their manager and the Giants hiring Buster Posey as president of baseball operations.
While things won’t change overnight, a win in the opener could be a positive sign for either team’s new outlook.
Here’s a look at the latest MLB betting lines and my Giants vs. Reds prediction for Opening Day.
Giants vs. Reds Odds: Thursday, March 27
- Giants moneyline: -110
- Reds moneyline: -110
- Game total: 7.5
Giants vs. Reds Opening Day Starting Pitchers
The Giants vs. Reds opener marked the first matchup with both starting pitchers confirmed on Opening Day, illustrating how much these teams believe in their aces.
San Francisco right-hander Logan Webb led the NL in innings for the second year in a row, logging 204 2/3 frames with a 3.47 ERA in 2024. Cincinnati righty Hunter Greene leveled up last season, tossing a 2.75 ERA and 169 strikeouts in 150 1/3 innings.
- Giants starting pitcher: Logan Webb
- Reds starting pitcher: Hunter Greene
Giants vs. Reds Prediction for Opening Day
Based on the latest MLB betting lines, I’m backing Cincinnati’s moneyline price (-110) as my Giants vs. Reds prediction for Opening Day.
The Reds are an intriguing dark horse in the NL Central, especially when Greene is on the mound. The hard-throwing righty led the NL with a 6.3 WAR last year, which tied AL Cy Young winner Tarik Skubal for the best mark in baseball.
Greene has touched triple digits with his fastball 472 times in his three MLB seasons, which marks the most by a starting pitcher in the pitch-tracking era.
The Giants should have an improved lineup after signing shortstop Willy Adames, but they ranked 19th with a wRC+ of 97 last year.
Greene looks ready to go this spring, and I think he will set the tone in Game 1.
Giants vs. Reds Prediction: Reds Moneyline (-110)
How to Watch Giants vs. Reds on Opening Day
- Date: Thursday, March 27
- Time: 4:10 p.m. ET
- Location: Great American Ball Park
- TV info: NBCSBA, FDSNOH (MLB TV)
Giants 2025 Schedule
Reds 2025 Schedule
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