• The Guardians are -105 favorites vs the Cardinals
• Guardians vs Cardinals Over / Under today: 8.5 Runs
• Guardians / Cardinals TV Channel: GDTV | CATV

The Cleveland Guardians (-105) visit Busch Stadium to take on the St. Louis Cardinals (-115) on April 15, 2026. First pitch is scheduled for 1:15 pm in St. Louis, MO.

This season, the Guardians are 10-8 against the spread (ATS), while the Cardinals are 8-8 ATS.

Guardians vs Cardinals Starting Pitchers Today:

• Guardians starting pitcher: Slade Cecconi 0-2, 5.75 ERA
• Cardinals starting pitcher: Dustin May 1-2, 9.70 ERA

Guardians vs. Cardinals Odds, Run Line, Over/Under & Moneyline

Guardians vs Cardinals Prediction for Today’s Game

Based on recent trends the model predicts the Cardinals will win Wednesday‘s MLB game with 53.1% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

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We’ve highlighted some favorite MLB player prop bets for Guardians players for Wednesday‘s game, looking at profitable historical betting trends:

Best Guardians Player Prop Bets Today:

• Brayan Rocchio has hit the Home Runs Over in 2 of his last 8 games (+16.00 Units / 200% ROI)
• Jose Ramirez has hit the Runs Over in 15 of his last 25 away games (+7.65 Units / 30% ROI)
• George Valera has hit the Hits Runs and RBIs Over in 8 of his last 10 games (+6.95 Units / 57% ROI)
• Steven Kwan has hit the Singles Under in 15 of his last 25 games (+6.90 Units / 27% ROI)
• Angel Martinez has hit the Total Bases Over in 6 of his last 7 games (+6.75 Units / 81% ROI)

And here are some favorite MLB player prop bets for Cardinals players for Wednesday‘s game, looking at profitable historical betting trends:

Best Cardinals Player Prop Best Bets Today:

• Jordan Walker has hit the Home Runs Over in 7 of his last 10 games (+36.10 Units / 361% ROI)
• Jordan Walker has hit the Runs Over in 15 of his last 25 games (+12.65 Units / 50% ROI)
• Ivan Herrera has hit the Walks Over in 11 of his last 15 games (+12.10 Units / 80% ROI)
• Jordan Walker has hit the Hits Over in his last 10 games (+10.00 Units / 50% ROI)
• Jordan Walker has hit the Hits Runs and RBIs Over in 17 of his last 25 games (+9.75 Units / 34% ROI)

Guardians Best Bets Today:

• The Cleveland Guardians have hit the Moneyline in 30 of their last 45 games (+18.75 Units / 36% ROI)
• The Cleveland Guardians have covered the Run Line in 28 of their last 45 games (+11.95 Units / 20% ROI)
• The Cleveland Guardians have covered the 1st Five Innings (F5) Run Line in 32 of their last 50 away games (+11.90 Units / 20% ROI)
• The Cleveland Guardians have hit the 1st Five Innings (F5) Moneyline in 14 of their last 24 away games (+9.35 Units / 37% ROI)
• The Cleveland Guardians have hit the Game Total Under in 27 of their last 45 games (+9.20 Units / 18% ROI)

Cardinals Best Bets Today:

• The St. Louis Cardinals have hit the 1st Five Innings (F5) Team Total Under in 25 of their last 40 games at home (+10.70 Units / 23% ROI)
• The St. Louis Cardinals have hit the Team Total Under in 24 of their last 40 games at home (+6.40 Units / 14% ROI)
• The St. Louis Cardinals have hit the Game Total Over in 14 of their last 23 games (+5.30 Units / 21% ROI)
• The St. Louis Cardinals have hit the Moneyline in 13 of their last 22 games at home (+4.95 Units / 22% ROI)
• The St. Louis Cardinals have covered the 1st Five Innings (F5) Run Line in 9 of their last 14 games at home (+2.55 Units / 14% ROI)

Guardians Against the Spread (ATS) Record

Against the spread this season, the Guardians are 10-8 against the Run Line (+0.55 Units / 2.28% ROI).

• 10-8 when betting on the Moneyline for +4.9 Units / 25.79% ROI
• 9-9 when betting on the total runs Over for -0.8 Units / -4.05% ROI
• 9-9 when betting on the total runs Under for -1.05 Units / -5.26% ROI

Cardinals Against the Spread (ATS) Record

Against the spread this season, the Cardinals are 8-8 against the Run Line (-3.3 Units / -13.61% ROI).

• 9-8 when betting on the Moneyline for +2.15 Units / 12.29% ROI
• 10-6 when betting on the total runs Over for +3.5 Units / 19.02% ROI
• 6-10 when betting on the total runs Under for -5.3 Units / -27.75% ROI

Guardians Keys to the Game vs. the Cardinals

The Guardians are just 0-6 (.000) when trailing entering the 8th inning this season — tied for lowest in MLB; League Avg: .101.

The Guardians were 33-4 (.868) when they had 10 or more hits in the 2025 season — 2nd best in MLB; League Avg: .743.

The Guardians are just 0-6 (.000) when trailing entering the 7th inning this season — tied for lowest in MLB; League Avg: .124.

The Guardians are 142-7 (.953) when leading entering the 7th inning since the 2024 season — best in MLB; League Avg: .866.

Cardinals Keys to the Game vs. the Guardians

The Cardinals are 69-4 (.945) when leading entering the 8th inning since the 2025 season — 5th best in MLB; League Avg: .908.

The Cardinals were just 7-11 (.389) when tied entering the 8th inning in the 2025 season — tied for 5th lowest in MLB; League Avg: .500.

The Cardinals are 1-8 (.111) when trailing entering the 9th inning this season — tied for 5th best in MLB; League Avg: .034.

The Cardinals are 29-18 (.617) when tied entering the 7th inning since the 2024 season — 3rd best in MLB; League Avg: .499.

Guardians Hitting Stats & Trends

Guardians hitters had an OPS of just .545 (690 PA’s) in righty-righty matchups in the 2025 season — lowest in MLB.

The Guardians batted just .223 against LHP in the 2025 season — 3rd lowest in MLB.

Guardians hitters had a Hard-Hit Rate of just 36% in the 2025 season — lowest in MLB.

Guardians hitters slugged just .295 in righty-righty matchups in the 2025 season — lowest in MLB.

Cardinals Hitting Stats & Trends

Cardinals hitters are slugging just .377 against RHP since the 2025 season — 3rd lowest in MLB.

Cardinals hitters are slugging just .485 with the pitcher behind in the count since the 2025 season — lowest in MLB.

Cardinals hitters had an OPS of just .692 (4,388 PA’s) against RHP in the 2025 season — 5th lowest in MLB.

Cardinals hitters slugged just .378 in the 2025 season — 4th lowest in MLB.

Guardians Pitching Stats & Trends

Opponents had a chase percentage of just 26% against the Guardians pitchers in the 2025 season — lowest in MLB.

Guardians pitchers have a strikeout rate of 38% in close and late situations this season — best in MLB.

Opponents had a groundball batting average of just .207 against Guardians pitchers with runners on base in the 2024 season — best in MLB; League Avg: .262.

Guardians pitchers have a strikeout rate of 26% this season — 4th best in MLB.

Cardinals Pitching Stats & Trends

Cardinals pitchers have a strikeout rate of just 31% with two-strikes this season — lowest in MLB.

Cardinals pitchers have a strikeout rate of just 15% this season — lowest in MLB.

Opponents have a miss rate of just 19% against Cardinals pitchers this season — lowest in MLB.

Cardinals pitchers have a strikeout rate of just 19% since the 2025 season — 2nd lowest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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