• The Phillies are -185 favorites vs the Guardians
• Guardians vs Phillies Over / Under today: 7 Runs
• Guardians / Phillies TV Channel: GDTV | NSPA

The Cleveland Guardians (+150) visit Citizens Bank Park to take on the Philadelphia Phillies (-185) on May 22, 2026. First pitch is scheduled for 6:40 pm in Philadelphia, PA.

This season, the Guardians are 30-22 against the spread (ATS), while the Phillies are 15-35 ATS.

Guardians vs Phillies Starting Pitchers Today:

• Guardians starting pitcher: Gavin Williams 6-3, 3.63 ERA
• Phillies starting pitcher: Cristopher Sanchez 5-2, 1.81 ERA

Guardians vs. Phillies Odds, Run Line, Over/Under & Moneyline

Guardians vs Phillies Prediction for Today’s Game

Based on recent trends the model predicts the Phillies will win Friday‘s MLB game with 60.4% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Guardians vs Phillies and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Guardians players for Friday‘s game, looking at profitable historical betting trends:

Best Guardians Player Prop Bets Today:

• Angel Martinez has hit the Home Runs Over in 4 of his last 9 games (+23.90 Units / 266% ROI)
• Steven Kwan has hit the Hits Under in 10 of his last 15 games (+9.25 Units / 48% ROI)
• Rhys Hoskins has hit the Runs Over in 14 of his last 25 games (+9.25 Units / 37% ROI)
• Steven Kwan has hit the Total Bases Under in 19 of his last 25 games (+9.15 Units / 21% ROI)
• Steven Kwan has hit the Hits Runs and RBIs Under in 17 of his last 25 games (+8.65 Units / 31% ROI)

And here are some favorite MLB player prop bets for Phillies players for Friday‘s game, looking at profitable historical betting trends:

Best Phillies Player Prop Best Bets Today:

• Alec Bohm has hit the Home Runs Over in 3 of his last 5 games at home (+18.40 Units / 368% ROI)
• Brandon Marsh has hit the Hits Over in 22 of his last 25 games (+17.30 Units / 35% ROI)
• Brandon Marsh has hit the Singles Over in 19 of his last 25 games (+13.25 Units / 47% ROI)
• Brandon Marsh has hit the Runs Over in 13 of his last 20 games (+10.55 Units / 53% ROI)
• Alec Bohm has hit the Total Bases Under in 19 of his last 25 games at home (+9.90 Units / 24% ROI)

Guardians Best Bets Today:

• The Cleveland Guardians have hit the Moneyline in 25 of their last 40 away games (+15.35 Units / 36% ROI)
• The Cleveland Guardians have covered the 1st Five Innings (F5) Run Line in 33 of their last 50 away games (+14.20 Units / 24% ROI)
• The Cleveland Guardians have hit the 1st Five Innings (F5) Moneyline in 21 of their last 40 away games (+12.60 Units / 29% ROI)
• The Cleveland Guardians have hit the 1st Five Innings (F5) Team Total Over in 11 of their last 14 away games (+7.75 Units / 47% ROI)
• The Cleveland Guardians have covered the Run Line in 9 of their last 15 games (+4.95 Units / 27% ROI)

Phillies Best Bets Today:

• The Philadelphia Phillies have hit the Moneyline in 17 of their last 24 games (+7.95 Units / 23% ROI)
• The Philadelphia Phillies have hit the 1st Five Innings (F5) Team Total Under in 30 of their last 50 games (+7.65 Units / 13% ROI)
• The Philadelphia Phillies have hit the Game Total Under in 8 of their last 10 games (+5.80 Units / 52% ROI)
• The Philadelphia Phillies have hit the Team Total Under in 21 of their last 35 games at home (+4.05 Units / 10% ROI)
• The Philadelphia Phillies have covered the 1st Five Innings (F5) Run Line in 14 of their last 25 games (+1.65 Units / 6% ROI)

Guardians Against the Spread (ATS) Record

Against the spread this season, the Guardians are 27-25 against the Run Line (+3.2 Units / 4.95% ROI).

• 30-22 when betting on the Moneyline for +7.85 Units / 12.51% ROI
• 26-26 when betting on the total runs Over for -2.2 Units / -3.86% ROI
• 26-26 when betting on the total runs Under for -2.7 Units / -4.68% ROI

Phillies Against the Spread (ATS) Record

Against the spread this season, the Phillies are 15-35 against the Run Line (-23.1 Units / -39.19% ROI).

• 25-25 when betting on the Moneyline for -7.65 Units / -10.52% ROI
• 24-24 when betting on the total runs Over for -2.25 Units / -4.08% ROI
• 24-24 when betting on the total runs Under for -2.1 Units / -3.83% ROI

Phillies vs Guardians Home Run Prop Bets Today

Phillies vs Guardians Total Hits Prop Bets Today

Phillies vs Guardians Strikeout Prop Bets Today

Guardians Keys to the Game vs. the Phillies

The Guardians are 9-2 (.818) when they’ve hit 2 or more home runs this season — 5th best in MLB; League Avg: .702.

The Guardians are 21-1 (.955) when leading entering the 7th inning this season — 4th best in MLB; League Avg: .863.

The Guardians are 10-1 (.909) when they’ve had 10 or more hits this season — 5th best in MLB; League Avg: .755.

The Guardians are 43-5 (.878) when they’ve had 10 or more hits since the 2025 season — 2nd best in MLB; League Avg: .745.

Phillies Keys to the Game vs. the Guardians

The Phillies are just 1-12 (.077) when allowing 2 or more home runs this season — 2nd lowest in MLB; League Avg: .298.

The Phillies are 6-0 (1.000) when they’ve had 5 or more XBH this season — tied for best in MLB; League Avg: .802.

The Phillies are 21-69 (.233) when trailing entering the 7th inning since the 2025 season — best in MLB; League Avg: .127.

The Phillies are 100-28 (.781) when allowing 4 or fewer runs since the 2025 season — best in MLB; League Avg: .716.

Guardians Hitting Stats & Trends

9% of Guardians’ hitters plate appearances have lasted only one pitch (174/1,966 PA’s) this season — 2nd lowest in MLB.

Guardians hitters have drawn walks in 12% of their PA’s against RHP this season — 3rd best in MLB.

Guardians hitters have chased 22% of pitches out of the zone in righty-righty matchups this season — lowest in MLB.

Guardians hitters have struck out in just 20% of their PA’s this season — 3rd best in MLB.

Phillies Hitting Stats & Trends

Phillies hitters have an OBP of just .216 (997 PA’s) with two-strikes this season — lowest in MLB.

Phillies hitters are slugging just .350 on the road this season — tied for 2nd lowest in MLB.

Phillies hitters have an OPS of just .631 (880 PA’s) on the road this season — 2nd lowest in MLB.

Phillies hitters have an OBP of just .282 (880 PA’s) on the road this season — lowest in MLB.

Guardians Pitching Stats & Trends

Guardians pitchers have a strikeout rate of 35% in close and late situations this season — best in MLB.

Guardians pitchers have a strikeout rate of 29% in late innings this season — best in MLB.

Opponents have a miss rate of 28% against Guardians pitchers this season — 2nd best in MLB.

Guardians pitchers have struck out 27% of left-handed batters they faced this season — best in MLB.

Phillies Pitching Stats & Trends

Phillies pitchers have walked 7% of batters this season — 2nd best in MLB.

Phillies pitchers have a strikeout rate of 47% with two-strikes this season — 2nd best in MLB.

Opponents have a groundball batting average of .292 against Phillies pitchers this season — highest in MLB.

Phillies pitchers have a strikeout rate of 25% this season — 4th best in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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