• The Guardians are -140 favorites vs the Reds
• Guardians vs Reds Over / Under today: 9 Runs
• Guardians / Reds TV Channel: GDTV | RDTV

The Cleveland Guardians (-140) visit Great American Ball Park to take on the Cincinnati Reds (+115) on July 29, 2026. First pitch is scheduled for 7:10 pm in Cincinnati, OH.

This season, the Guardians are 55-54 against the spread (ATS), while the Reds are 58-47 ATS.

Guardians vs Reds Starting Pitchers Today:

• Guardians starting pitcher: Joey Cantillo 8-6, 4.04 ERA
• Reds starting pitcher: Brady Singer 5-9, 4.53 ERA

Guardians vs. Reds Odds, Run Line, Over/Under & Moneyline

Guardians vs Reds Prediction for Today’s Game

Based on recent trends the model predicts the Guardians will win Wednesday‘s MLB game with 53.7% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Guardians vs Reds and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Guardians players for Wednesday‘s game, looking at profitable historical betting trends:

Best Guardians Player Prop Bets Today:

• Patrick Bailey has hit the Home Runs Over in 3 of his last 10 games (+15.60 Units / 156% ROI)
• Jose Ramirez has hit the Walks Under in 21 of his last 25 games (+13.05 Units / 26% ROI)
• Brayan Rocchio has hit the Hits Runs and RBIs Over in 18 of his last 25 games (+11.15 Units / 41% ROI)
• Gabriel Arias has hit the Singles Over in 15 of his last 25 games (+10.60 Units / 42% ROI)
• Gabriel Arias has hit the Total Bases Over in 19 of his last 25 games (+10.55 Units / 30% ROI)

And here are some favorite MLB player prop bets for Reds players for Wednesday‘s game, looking at profitable historical betting trends:

Best Reds Player Prop Best Bets Today:

• Tyler Stephenson has hit the Runs Under in 21 of his last 25 games at home (+14.60 Units / 33% ROI)
• Jose Trevino has hit the Home Runs Over in 2 of his last 8 games (+13.50 Units / 169% ROI)
• Noelvi Marte has hit the Singles Under in 17 of his last 20 games at home (+12.80 Units / 47% ROI)
• Noelvi Marte has hit the Hits Runs and RBIs Under in 19 of his last 25 games (+11.10 Units / 32% ROI)
• Brady Singer has hit the Strikeouts Over in his last 9 games (+9.75 Units / 92% ROI)

Guardians Best Bets Today:

• The Cleveland Guardians have hit the Game Total Under in 23 of their last 35 away games (+9.45 Units / 24% ROI)
• The Cleveland Guardians have hit the 1st Five Innings (F5) Team Total Under in 22 of their last 35 games (+9.10 Units / 22% ROI)
• The Cleveland Guardians have hit the Team Total Under in 27 of their last 45 away games (+6.95 Units / 13% ROI)
• The Cleveland Guardians have hit the 1st Five Innings (F5) Moneyline in 21 of their last 50 away games (+6.50 Units / 12% ROI)
• The Cleveland Guardians have hit the Moneyline in 19 of their last 35 away games (+5.35 Units / 14% ROI)

Reds Best Bets Today:

• The Cincinnati Reds have hit the Team Total Under in 32 of their last 50 games at home (+11.65 Units / 20% ROI)
• The Cincinnati Reds have hit the 1st Five Innings (F5) Team Total Under in 16 of their last 23 games at home (+7.70 Units / 27% ROI)
• The Cincinnati Reds have hit the Game Total Under in 15 of their last 22 games at home (+7.55 Units / 31% ROI)
• The Cincinnati Reds have covered the 1st Five Innings (F5) Run Line in 24 of their last 40 games (+6.40 Units / 14% ROI)
• The Cincinnati Reds have hit the 1st Five Innings (F5) Moneyline in 4 of their last 7 games at home (+4.25 Units / 47% ROI)

Guardians Against the Spread (ATS) Record

Against the spread this season, the Guardians are 52-56 against the Run Line (-7.9 Units / -5.56% ROI).

• 55-54 when betting on the Moneyline for -1.7 Units / -1.32% ROI
• 51-58 when betting on the total runs Over for -12.25 Units / -10.3% ROI
• 58-51 when betting on the total runs Under for +1.25 Units / 1.03% ROI

Reds Against the Spread (ATS) Record

Against the spread this season, the Reds are 58-47 against the Run Line (-1.9 Units / -1.27% ROI).

• 50-56 when betting on the Moneyline for -5.65 Units / -4.77% ROI
• 57-48 when betting on the total runs Over for +4.15 Units / 3.54% ROI
• 48-57 when betting on the total runs Under for -14.1 Units / -12.15% ROI

Reds vs Guardians Home Run Prop Bets Today

Reds vs Guardians Total Hits Prop Bets Today

Reds vs Guardians Strikeout Prop Bets Today

Guardians Keys to the Game vs. the Reds

The Guardians are 18-4 (.818) when they’ve hit 2 or more home runs this season — 4th best in MLB; League Avg: .697.

The Guardians are 11-1 (.917) when they’ve had 5 or more XBH this season — tied for 4th best in MLB; League Avg: .790.

The Guardians are 11-1 (.917) when they’ve had 5 or more XBH since the 2025 season — tied for 4th best in MLB; League Avg: .790.

The Guardians are 18-4 (.818) when they’ve hit 2 or more home runs since the 2025 season — 4th best in MLB; League Avg: .697.

Reds Keys to the Game vs. the Guardians

The Reds are 42-11 (.792) when allowing 4 or fewer runs this season — tied for 4th best in MLB; League Avg: .723.

The Reds are 5-49 (.093) when trailing entering the 9th inning this season — tied for 2nd best in MLB; League Avg: .052.

The Reds are just 5-29 (.147) when allowing 10 or more hits this season — 4th lowest in MLB; League Avg: .247.

The Reds are just 8-45 (.151) when allowing 5 or more runs this season — 4th lowest in MLB; League Avg: .211.

Guardians Hitting Stats & Trends

The Guardians are batting just .193 when facing the starting pitcher for the 3rd time in a game this season — lowest in MLB.

The Guardians are batting just .214 on the road this season — lowest in MLB.

Guardians hitters have an OBP of just .260 (452 PA’s) when facing the starting pitcher for the 3rd time in a game this season — lowest in MLB.

Guardians hitters have an OBP of just .290 (2,078 PA’s) on the road this season — 2nd lowest in MLB.

Reds Hitting Stats & Trends

The Reds are batting just .115 on pitches out of the zone this season — lowest in MLB.

Reds hitters have struck out in 25% of their PA’s against RHP this season — highest in MLB.

The Reds are batting just .214 with two outs this season — lowest in MLB.

The Reds are batting just .220 with runners on base this season — lowest in MLB.

Guardians Pitching Stats & Trends

Guardians pitchers have a strikeout rate of 25% this season — 4th best in MLB.

Opponents have a miss rate of 27% against Guardians pitchers this season — 5th best in MLB.

Guardians pitchers have a strikeout rate of 27% in late innings this season — best in MLB.

Guardians pitchers have a strikeout rate of 25% with runners in scoring position this season — 2nd best in MLB.

Reds Pitching Stats & Trends

Reds pitchers have walked 11% of batters this season — 2nd highest in MLB.

The Reds pitchers have allowed their opponents to score first in 58% of their games this season — 2nd highest in MLB.

Reds pitchers have walked 10% of batters when facing the leadoff batter in the inning this season — 4th highest in MLB.

Reds pitchers have a first-pitch strike rate of just 59% this season — lowest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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