• The Guardians are -140 favorites vs the Royals
• Guardians vs Royals Over / Under today: 7 Runs
• Guardians / Royals TV Channel: GDTV | RYTV

The Cleveland Guardians (-140) visit Kauffman Stadium to take on the Kansas City Royals (+115) on September 25, 2026. First pitch is scheduled for 7:40 pm in Kansas City, MO.

This season, the Guardians are 83-76 against the spread (ATS), while the Royals are 74-79 ATS.

Guardians vs Royals Starting Pitchers Today:

• Guardians starting pitcher: Gavin Williams 14-8, 3.64 ERA
• Royals starting pitcher: Noah Cameron 9-8, 3.91 ERA

Guardians vs. Royals Odds, Run Line, Over/Under & Moneyline

Guardians vs Royals Prediction for Today’s Game

Based on recent trends the model predicts the Guardians will win Friday‘s MLB game with 57.7% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

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We’ve highlighted some favorite MLB player prop bets for Guardians players for Friday‘s game, looking at profitable historical betting trends:

Best Guardians Player Prop Bets Today:

• Angel Martinez has hit the Home Runs Over in 3 of his last 8 games (+18.10 Units / 226% ROI)
• Angel Martinez has hit the Hits Over in 14 of his last 15 away games (+12.85 Units / 46% ROI)
• Angel Martinez has hit the Total Bases Over in 12 of his last 15 away games (+11.80 Units / 63% ROI)
• Steven Kwan has hit the Singles Over in 19 of his last 25 away games (+9.60 Units / 24% ROI)
• Steven Kwan has hit the Walks Over in 7 of his last 10 games (+8.45 Units / 85% ROI)

And here are some favorite MLB player prop bets for Royals players for Friday‘s game, looking at profitable historical betting trends:

Best Royals Player Prop Best Bets Today:

• Nick Loftin has hit the Home Runs Over in 3 of his last 10 games at home (+22.00 Units / 220% ROI)
• Salvador Perez has hit the Runs Under in 22 of his last 25 games (+16.70 Units / 35% ROI)
• Salvador Perez has hit the RBIs Over in 16 of his last 25 games at home (+15.70 Units / 63% ROI)
• Salvador Perez has hit the Hits Over in 21 of his last 25 games at home (+12.25 Units / 23% ROI)
• Vinnie Pasquantino has hit the Total Bases Over in 14 of his last 20 games at home (+12.00 Units / 56% ROI)

Guardians Best Bets Today:

• The Cleveland Guardians have hit the Game Total Under in 31 of their last 50 away games (+9.80 Units / 18% ROI)
• The Cleveland Guardians have hit the Moneyline in 20 of their last 30 games (+7.50 Units / 17% ROI)
• The Cleveland Guardians have covered the Run Line in 6 of their last 7 games (+5.50 Units / 54% ROI)
• The Cleveland Guardians have hit the 1st Five Innings (F5) Moneyline in 7 of their last 10 games (+5.50 Units / 35% ROI)
• The Cleveland Guardians have hit the Team Total Over in 29 of their last 50 games (+4.45 Units / 7% ROI)

Royals Best Bets Today:

• The Kansas City Royals have hit the Moneyline in 21 of their last 35 games at home (+7.50 Units / 19% ROI)
• The Kansas City Royals have hit the 1st Five Innings (F5) Team Total Over in 11 of their last 16 games at home (+6.60 Units / 37% ROI)
• The Kansas City Royals have hit the Game Total Under in 12 of their last 17 games (+6.55 Units / 35% ROI)
• The Kansas City Royals have hit the Team Total Under in 11 of their last 18 games (+3.65 Units / 18% ROI)
• The Kansas City Royals have hit the 1st Five Innings (F5) Moneyline in 8 of their last 16 games at home (+3.40 Units / 18% ROI)

Guardians Against the Spread (ATS) Record

Against the spread this season, the Guardians are 75-83 against the Run Line (-13.35 Units / -6.57% ROI).

• 83-76 when betting on the Moneyline for -2.35 Units / -1.17% ROI
• 75-82 when betting on the total runs Over for -14.1 Units / -8.16% ROI
• 82-75 when betting on the total runs Under for -1.55 Units / -0.87% ROI

Royals Against the Spread (ATS) Record

Against the spread this season, the Royals are 74-79 against the Run Line (-25.45 Units / -11.6% ROI).

• 68-91 when betting on the Moneyline for -21.9 Units / -12.44% ROI
• 71-83 when betting on the total runs Over for -19.75 Units / -11.28% ROI
• 83-71 when betting on the total runs Under for +5.6 Units / 3.2% ROI

Guardians Keys to the Game vs. the Royals

The Guardians are 18-20 (.474) when their opponents score in the first inning this season — 3rd best in MLB.

The Guardians are 60-5 (.923) when leading entering the 7th inning this season — 5th best in MLB.

The Guardians are 32-18 (.640) when tied entering the 8th inning since the 2024 season — 2nd best in MLB.

The Guardians were 82-0 (1.000) when leading entering the 9th inning in the 2024 season — best in MLB; League Avg: .949.

Royals Keys to the Game vs. the Guardians

The Royals are just 8-37 (.178) when allowing 2 or more home runs this season — 2nd lowest in MLB.

The Royals are just 55-13 (.809) when leading entering the 8th inning this season — 3rd lowest in MLB.

The Royals are just 68-91 (.428) this season — 5th lowest in MLB.

The Royals are just 65-75 (.464) when allowing 5 or more extra base hits this season — 5th lowest in MLB.

Guardians Hitting Stats & Trends

Guardians hitters have an OPS of just .643 (1,861 PA’s) in innings 7-9 this season — lowest in MLB.

Guardians hitters are slugging just .353 against LHP this season — 2nd lowest in MLB.

Guardians hitters are slugging just .375 this season — 2nd lowest in MLB.

The Guardians are batting just .221 with two outs this season — 3rd lowest in MLB.

Royals Hitting Stats & Trends

Royals hitters have put 40% of their swings in play on the first pitch of at-bats this season — highest in MLB.

Royals hitters are slugging just .192 on pitches out of the zone this season — 4th lowest in MLB.

Royals hitters have an OPS of just .665 (3,064 PA’s) on the road this season — 3rd lowest in MLB.

Royals hitters are slugging just .363 with runners in scoring position this season — lowest in MLB.

Guardians Pitching Stats & Trends

Guardians pitchers have a strikeout rate of 46% with two-strikes this season — 3rd best in MLB.

Guardians pitchers have a strikeout rate of 31% in close and late situations this season — best in MLB.

Guardians pitchers have a strikeout rate of 26% with runners in scoring position this season — best in MLB.

Opponents have a miss rate of 27% against Guardians pitchers this season — 4th best in MLB.

Royals Pitching Stats & Trends

Royals pitchers have a strikeout rate of just 38% with two-strikes this season — 2nd lowest in MLB.

Opponents have a miss rate of just 23% against Royals pitchers this season — tied for 3rd lowest in MLB.

Royals pitchers have a strikeout rate of just 19% this season — 3rd lowest in MLB.

Royals pitchers have 197 three-pitch strikeouts this season — 4th fewest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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