• The Guardians are -130 favorites vs the Tigers
• Guardians vs Tigers Over / Under today: 7.5 Runs
• Guardians / Tigers TV Channel: GDTV | DSN

The Cleveland Guardians (-130) visit Comerica Park to take on the Detroit Tigers (+105) on May 20, 2026. First pitch is scheduled for 6:40 pm in Detroit, MI.

This season, the Guardians are 28-22 against the spread (ATS), while the Tigers are 20-26 ATS.

Guardians vs Tigers Starting Pitchers Today:

• Guardians starting pitcher: Tanner Bibee 0-6, 4.16 ERA
• Tigers starting pitcher: Brenan Hanifee 0-0, 1.93 ERA

Guardians vs. Tigers Odds, Run Line, Over/Under & Moneyline

Guardians vs Tigers Prediction for Today’s Game

Based on recent trends the model predicts the Guardians will win Wednesday‘s MLB game with 56.3% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

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We’ve highlighted some favorite MLB player prop bets for Guardians players for Wednesday‘s game, looking at profitable historical betting trends:

Best Guardians Player Prop Bets Today:

• Angel Martinez has hit the Home Runs Over in 4 of his last 7 games (+25.90 Units / 370% ROI)
• Patrick Bailey has hit the Runs Under in 14 of his last 15 away games (+11.85 Units / 33% ROI)
• Patrick Bailey has hit the Hits Runs and RBIs Under in 15 of his last 20 games (+11.35 Units / 47% ROI)
• Steven Kwan has hit the Hits Under in 11 of his last 15 games (+11.00 Units / 50% ROI)
• Steven Kwan has hit the Total Bases Under in 20 of his last 25 games (+10.85 Units / 24% ROI)

And here are some favorite MLB player prop bets for Tigers players for Wednesday‘s game, looking at profitable historical betting trends:

Best Tigers Player Prop Best Bets Today:

• Matt Vierling has hit the Home Runs Over in 3 of his last 7 games at home (+21.00 Units / 300% ROI)
• Zach McKinstry has hit the Runs Under in 22 of his last 25 games (+15.60 Units / 28% ROI)
• Riley Greene has hit the Total Bases Over in 18 of his last 25 games (+15.00 Units / 53% ROI)
• Riley Greene has hit the Hits Over in 21 of his last 25 games (+12.90 Units / 26% ROI)
• Riley Greene has hit the Singles Over in 17 of his last 25 games (+11.05 Units / 44% ROI)

Guardians Best Bets Today:

• The Cleveland Guardians have covered the 1st Five Innings (F5) Run Line in 34 of their last 50 away games (+16.20 Units / 27% ROI)
• The Cleveland Guardians have hit the Moneyline in 22 of their last 35 away games (+13.95 Units / 37% ROI)
• The Cleveland Guardians have hit the 1st Five Innings (F5) Moneyline in 25 of their last 50 away games (+12.60 Units / 23% ROI)
• The Cleveland Guardians have hit the 1st Five Innings (F5) Team Total Over in 10 of their last 12 away games (+8.20 Units / 58% ROI)
• The Cleveland Guardians have hit the Team Total Over in 9 of their last 12 games (+5.75 Units / 40% ROI)

Tigers Best Bets Today:

• The Detroit Tigers have hit the Team Total Under in 11 of their last 13 games (+8.80 Units / 57% ROI)
• The Detroit Tigers have hit the Game Total Over in 28 of their last 50 games at home (+7.25 Units / 13% ROI)
• The Detroit Tigers have covered the Run Line in 12 of their last 24 games at home (+4.75 Units / 17% ROI)
• The Detroit Tigers have hit the 1st Five Innings (F5) Team Total Under in 5 of their last 6 games at home (+4.00 Units / 52% ROI)
• The Detroit Tigers have hit the Moneyline in 14 of their last 24 games at home (+2.30 Units / 7% ROI)

Guardians Against the Spread (ATS) Record

Against the spread this season, the Guardians are 26-24 against the Run Line (+3.2 Units / 5.19% ROI).

• 28-22 when betting on the Moneyline for +5.75 Units / 9.5% ROI
• 26-24 when betting on the total runs Over for -0.2 Units / -0.36% ROI
• 24-26 when betting on the total runs Under for -4.7 Units / -8.51% ROI

Tigers Against the Spread (ATS) Record

Against the spread this season, the Tigers are 20-26 against the Run Line (-8.25 Units / -13.12% ROI).

• 20-29 when betting on the Moneyline for -13.1 Units / -21.87% ROI
• 22-25 when betting on the total runs Over for -5.55 Units / -10.26% ROI
• 25-22 when betting on the total runs Under for +0.95 Units / 1.77% ROI

Guardians Keys to the Game vs. the Tigers

The Guardians are 20-1 (.952) when leading entering the 7th inning this season — 4th best in MLB; League Avg: .866.

The Guardians are 9-2 (.818) when they’ve hit 2 or more home runs this season — 5th best in MLB; League Avg: .706.

The Guardians are 10-1 (.909) when they’ve had 10 or more hits this season — 5th best in MLB; League Avg: .752.

The Guardians are just 0-20 (.000) when trailing entering the 9th inning this season — tied for lowest in MLB; League Avg: .052.

Tigers Keys to the Game vs. the Guardians

The Tigers are just 14-7 (.667) when leading entering the 7th inning this season — lowest in MLB; League Avg: .866.

The Tigers are just 1-9 (.100) when their opponents score in the first inning this season — lowest in MLB; League Avg: .359.

The Tigers are just 6-24 (.200) when scoring 4 or fewer runs this season — 4th lowest in MLB; League Avg: .278.

The Tigers are just 13-3 (.812) when leading entering the 8th inning this season — 3rd lowest in MLB; League Avg: .896.

Guardians Hitting Stats & Trends

Guardians hitters have struck out in just 19% of their PA’s against LHP this season — 4th best in MLB.

Guardians hitters have chased 22% of pitches out of the zone in righty-righty matchups this season — lowest in MLB.

Guardians hitters have an OBP of .339 (574 PA’s) against LHP this season — 4th best in MLB.

9% of Guardians’ hitters plate appearances have lasted only one pitch (164/1,891 PA’s) this season — tied for lowest in MLB.

Tigers Hitting Stats & Trends

Tigers hitters have chased 24% of pitches out of the zone against LHP this season — lowest in MLB.

Tigers hitters are slugging just .347 against LHP this season — 5th lowest in MLB.

Tigers hitters have drawn walks in 14% of their PA’s against LHP this season — best in MLB.

Tigers hitters have chased 26% of pitches out of the zone this season — lowest in MLB.

Guardians Pitching Stats & Trends

Guardians pitchers have a strikeout rate of 35% in close and late situations this season — best in MLB.

Guardians pitchers have a strikeout rate of 25% this season — tied for 2nd best in MLB.

Guardians pitchers have struck out 27% of left-handed batters they faced this season — best in MLB.

Opponents have a miss rate of 28% against Guardians pitchers this season — best in MLB.

Tigers Pitching Stats & Trends

Tigers pitchers have a first-pitch strike rate of 63% this season — 4th highest in MLB.

Tigers pitchers have 57 three-pitch strikeouts this season — tied for 4th fewest in MLB.

Tigers pitchers have induced opposing hitters to ground into 39 double plays in 358 opportunities (11%) this season — 4th best in MLB.

Tigers pitchers have 57 three-pitch strikeouts this season — tied for 4th fewest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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