• The Guardians are -102 favorites vs the Tigers
• Guardians vs Tigers Over / Under today: 7 Runs
• Guardians / Tigers TV Channel: GDTV | DSN | WJBK

The Cleveland Guardians (-102) visit Comerica Park to take on the Detroit Tigers (-118) on May 21, 2026. First pitch is scheduled for 1:10 pm in Detroit, MI.

This season, the Guardians are 29-22 against the spread (ATS), while the Tigers are 21-26 ATS.

Guardians vs Tigers Starting Pitchers Today:

• Guardians starting pitcher: Joey Cantillo 3-1, 3.42 ERA
• Tigers starting pitcher: Casey Mize 2-2, 2.43 ERA

Guardians vs. Tigers Odds, Run Line, Over/Under & Moneyline

Guardians vs Tigers Prediction for Today’s Game

Based on recent trends the model predicts the Tigers will win Thursday‘s MLB game with 51.0% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Guardians vs Tigers and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Guardians players for Thursday‘s game, looking at profitable historical betting trends:

Best Guardians Player Prop Bets Today:

• Angel Martinez has hit the Home Runs Over in 4 of his last 8 games (+24.90 Units / 311% ROI)
• Patrick Bailey has hit the Runs Under in 14 of his last 15 away games (+11.85 Units / 33% ROI)
• Angel Martinez has hit the Total Bases Over in 11 of his last 15 away games (+10.25 Units / 62% ROI)
• Patrick Bailey has hit the Hits Runs and RBIs Under in 14 of his last 20 games (+9.35 Units / 40% ROI)
• Steven Kwan has hit the Hits Under in 10 of his last 15 games (+9.00 Units / 44% ROI)

And here are some favorite MLB player prop bets for Tigers players for Thursday‘s game, looking at profitable historical betting trends:

Best Tigers Player Prop Best Bets Today:

• Matt Vierling has hit the Home Runs Over in 3 of his last 8 games at home (+20.00 Units / 250% ROI)
• Wenceel Perez has hit the Runs Under in 18 of his last 20 games at home (+13.55 Units / 34% ROI)
• Riley Greene has hit the Hits Over in 21 of his last 25 games (+12.90 Units / 26% ROI)
• Riley Greene has hit the Total Bases Over in 17 of his last 25 games (+12.60 Units / 44% ROI)
• Riley Greene has hit the Singles Over in 17 of his last 25 games (+11.30 Units / 45% ROI)

Guardians Best Bets Today:

• The Cleveland Guardians have covered the 1st Five Innings (F5) Run Line in 33 of their last 50 away games (+14.20 Units / 24% ROI)
• The Cleveland Guardians have hit the Moneyline in 22 of their last 35 away games (+13.65 Units / 36% ROI)
• The Cleveland Guardians have hit the 1st Five Innings (F5) Moneyline in 25 of their last 50 away games (+12.60 Units / 23% ROI)
• The Cleveland Guardians have hit the 1st Five Innings (F5) Team Total Over in 10 of their last 13 away games (+6.75 Units / 43% ROI)
• The Cleveland Guardians have hit the Team Total Over in 9 of their last 13 games (+4.45 Units / 29% ROI)

Tigers Best Bets Today:

• The Detroit Tigers have hit the Team Total Under in 12 of their last 14 games (+9.80 Units / 59% ROI)
• The Detroit Tigers have hit the Game Total Under in 14 of their last 21 games (+6.30 Units / 27% ROI)
• The Detroit Tigers have covered the Run Line in 13 of their last 25 games at home (+5.75 Units / 19% ROI)
• The Detroit Tigers have hit the 1st Five Innings (F5) Team Total Under in 6 of their last 7 games at home (+5.00 Units / 58% ROI)
• The Detroit Tigers have covered the 1st Five Innings (F5) Run Line in 13 of their last 24 games at home (+2.10 Units / 8% ROI)

Guardians Against the Spread (ATS) Record

Against the spread this season, the Guardians are 26-25 against the Run Line (+2.2 Units / 3.51% ROI).

• 29-22 when betting on the Moneyline for +6.75 Units / 10.93% ROI
• 26-25 when betting on the total runs Over for -1.2 Units / -2.14% ROI
• 25-26 when betting on the total runs Under for -3.7 Units / -6.55% ROI

Tigers Against the Spread (ATS) Record

Against the spread this season, the Tigers are 21-26 against the Run Line (-7.25 Units / -11.23% ROI).

• 20-30 when betting on the Moneyline for -14.1 Units / -23.15% ROI
• 22-26 when betting on the total runs Over for -6.55 Units / -11.89% ROI
• 26-22 when betting on the total runs Under for +1.95 Units / 3.55% ROI

Tigers vs Guardians Home Run Prop Bets Today

Tigers vs Guardians Total Hits Prop Bets Today

Tigers vs Guardians Strikeout Prop Bets Today

Guardians Keys to the Game vs. the Tigers

The Guardians are 20-1 (.952) when leading entering the 7th inning this season — 4th best in MLB; League Avg: .863.

The Guardians are 10-1 (.909) when they’ve had 10 or more hits this season — 5th best in MLB; League Avg: .754.

The Guardians are 9-2 (.818) when they’ve hit 2 or more home runs this season — 5th best in MLB; League Avg: .702.

The Guardians are 43-5 (.878) when they’ve had 10 or more hits since the 2025 season — 2nd best in MLB; League Avg: .745.

Tigers Keys to the Game vs. the Guardians

The Tigers are just 14-7 (.667) when leading entering the 7th inning this season — lowest in MLB; League Avg: .863.

The Tigers are just 13-4 (.765) when leading entering the 8th inning this season — lowest in MLB; League Avg: .893.

The Tigers are just 1-9 (.100) when their opponents score in the first inning this season — lowest in MLB; League Avg: .365.

The Tigers are just 2-17 (.105) when allowing 5 or more runs this season — 5th lowest in MLB; League Avg: .207.

Guardians Hitting Stats & Trends

9% of Guardians’ hitters plate appearances have lasted only one pitch (172/1,932 PA’s) this season — 2nd lowest in MLB.

Guardians hitters have chased 22% of pitches out of the zone in righty-righty matchups this season — lowest in MLB.

Guardians hitters are slugging just .361 against RHP this season — 2nd lowest in MLB.

Guardians hitters have a groundball batting average of just .196 this season — lowest in MLB.

Tigers Hitting Stats & Trends

The Tigers are batting just .215 against LHP this season — tied for 3rd lowest in MLB.

Tigers hitters are slugging just .346 against LHP this season — 5th lowest in MLB.

Tigers hitters have 12 extra-base hits out of 45 total hits (just 27%) when facing the starting pitcher for the 3rd time in a game this season — 2nd lowest in MLB.

The Tigers are batting just .225 when facing the starting pitcher for the 3rd time in a game this season — tied for 4th lowest in MLB.

Guardians Pitching Stats & Trends

Guardians pitchers have a strikeout rate of 35% in close and late situations this season — best in MLB.

Guardians pitchers have a strikeout rate of 25% this season — tied for 2nd best in MLB.

Guardians pitchers have struck out 27% of left-handed batters they faced this season — best in MLB.

Guardians pitchers have a strikeout rate of 28% in late innings this season — best in MLB.

Tigers Pitching Stats & Trends

Tigers pitchers have 57 three-pitch strikeouts this season — 4th fewest in MLB.

Tigers pitchers have a first-pitch strike rate of 63% this season — 3rd highest in MLB.

Tigers pitchers have 57 three-pitch strikeouts this season — 4th fewest in MLB.

Tigers pitchers have induced opposing hitters to ground into 40 double plays in 365 opportunities (11%) this season — 4th best in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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