• The Twins are -135 favorites vs the Guardians
• Guardians vs Twins Over / Under today: 8 Runs
• Guardians / Twins TV Channel: GDTV | TWTV

The Cleveland Guardians (+110) visit Target Field to take on the Minnesota Twins (-135) on September 13, 2026. First pitch is scheduled for 2:10 pm in Minneapolis, MN.

This season, the Guardians are 75-74 against the spread (ATS), while the Twins are 78-68 ATS.

Guardians vs Twins Starting Pitchers Today:

• Guardians starting pitcher: Tanner Bibee 5-15, 4.26 ERA
• Twins starting pitcher: Undecided 0-0, 0.00 ERA

Guardians vs. Twins Odds, Run Line, Over/Under & Moneyline

Guardians vs Twins Prediction for Today’s Game

Based on recent trends the model predicts the Guardians will win Sunday‘s MLB game with 51.0% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

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We’ve highlighted some favorite MLB player prop bets for Guardians players for Sunday‘s game, looking at profitable historical betting trends:

Best Guardians Player Prop Bets Today:

• Steven Kwan has hit the Hits Over in 20 of his last 25 away games (+14.90 Units / 32% ROI)
• Angel Martinez has hit the Home Runs Over in 3 of his last 10 games (+13.60 Units / 136% ROI)
• Jose Ramirez has hit the RBIs Under in 21 of his last 25 games (+12.80 Units / 25% ROI)
• Angel Martinez has hit the Total Bases Over in 17 of his last 25 games (+11.55 Units / 38% ROI)
• Steven Kwan has hit the Singles Over in 19 of his last 25 away games (+10.10 Units / 27% ROI)

And here are some favorite MLB player prop bets for Twins players for Sunday‘s game, looking at profitable historical betting trends:

Best Twins Player Prop Best Bets Today:

• Royce Lewis has hit the Runs Under in 22 of his last 25 games (+16.80 Units / 40% ROI)
• Ryan Jeffers has hit the Hits Over in 18 of his last 20 games at home (+13.70 Units / 33% ROI)
• Ryan Jeffers has hit the Total Bases Over in 14 of his last 20 games at home (+11.55 Units / 54% ROI)
• Ryan Jeffers has hit the Home Runs Over in 3 of his last 9 games (+11.10 Units / 123% ROI)
• Walker Jenkins has hit the Singles Under in his last 10 games (+10.00 Units / 60% ROI)

Guardians Best Bets Today:

• The Cleveland Guardians have hit the Game Total Under in 32 of their last 50 away games (+11.80 Units / 21% ROI)
• The Cleveland Guardians have hit the Moneyline in 27 of their last 50 away games (+4.75 Units / 8% ROI)
• The Cleveland Guardians have hit the Team Total Over in 12 of their last 19 away games (+3.90 Units / 17% ROI)
• The Cleveland Guardians have hit the 1st Five Innings (F5) Team Total Under in 10 of their last 16 games (+3.15 Units / 16% ROI)
• The Cleveland Guardians have covered the Run Line in 25 of their last 45 away games (+1.35 Units / 2% ROI)

Twins Best Bets Today:

• The Minnesota Twins have hit the Game Total Under in 19 of their last 30 games at home (+6.80 Units / 21% ROI)
• The Minnesota Twins have covered the 1st Five Innings (F5) Run Line in 9 of their last 12 games at home (+6.60 Units / 48% ROI)
• The Minnesota Twins have hit the 1st Five Innings (F5) Moneyline in 9 of their last 12 games at home (+6.55 Units / 47% ROI)
• The Minnesota Twins have covered the Run Line in 8 of their last 11 games at home (+4.95 Units / 30% ROI)
• The Minnesota Twins have hit the Team Total Under in 29 of their last 50 games (+4.75 Units / 8% ROI)

Guardians Against the Spread (ATS) Record

Against the spread this season, the Guardians are 68-80 against the Run Line (-17.85 Units / -9.44% ROI).

• 75-74 when betting on the Moneyline for -7.85 Units / -4.23% ROI
• 70-78 when betting on the total runs Over for -14.65 Units / -9.05% ROI
• 78-70 when betting on the total runs Under for +0 Units / 0% ROI

Twins Against the Spread (ATS) Record

Against the spread this season, the Twins are 78-68 against the Run Line (-8.6 Units / -4.07% ROI).

• 70-78 when betting on the Moneyline for -7.6 Units / -4.59% ROI
• 79-60 when betting on the total runs Over for +12.1 Units / 7.39% ROI
• 60-79 when betting on the total runs Under for -26.9 Units / -16.61% ROI

Guardians Keys to the Game vs. the Twins

The Guardians are 32-18 (.640) when tied entering the 8th inning since the 2024 season — 2nd best in MLB.

The Guardians were just 3-61 (.047) when trailing entering the 8th inning in the 2024 season — 2nd lowest in MLB; League Avg: .100.

The Guardians were 77-2 (.975) when leading entering the 8th inning in the 2024 season — best in MLB; League Avg: .899.

The Guardians are 190-12 (.941) when leading entering the 7th inning since the 2024 season — best in MLB.

Twins Keys to the Game vs. the Guardians

The Twins are just 14-9 (.609) when they’ve had 5 or more XBH this season — 2nd lowest in MLB.

The Twins are just 26-22 (.542) when they’ve hit 2 or more home runs this season — 2nd lowest in MLB.

The Twins are just 2-67 (.029) when trailing entering the 9th inning this season — 5th lowest in MLB.

The Twins are just 5-11 (.312) when tied entering the 7th inning this season — 4th lowest in MLB.

Guardians Hitting Stats & Trends

Guardians hitters are slugging just .371 this season — lowest in MLB.

Guardians hitters have an OPS of just .659 (1,719 PA’s) against LHP this season — 3rd lowest in MLB.

Guardians hitters are slugging just .346 against LHP this season — 2nd lowest in MLB.

The Guardians are batting just .226 against LHP this season — 2nd lowest in MLB.

Twins Hitting Stats & Trends

The Twins are batting just .302 on the first pitch of at-bats this season — lowest in MLB.

The Twins are batting just .233 against LHP this season — tied for 5th lowest in MLB.

Twins hitters are slugging .425 against RHP this season — 2nd best in MLB.

The Twins are batting .272 when facing the starting pitcher for the 3rd time in a game this season — 5th best in MLB.

Guardians Pitching Stats & Trends

Guardians pitchers have a strikeout rate of 30% in close and late situations this season — best in MLB.

Guardians pitchers have a strikeout rate of 25% this season — 4th best in MLB.

Guardians pitchers have an ERA of 3.26 (405.1 IP) against division opponents this season — 3rd best in MLB.

Guardians pitchers have a strikeout rate of 46% with two-strikes this season — tied for 3rd best in MLB.

Twins Pitching Stats & Trends

Twins pitchers have walked 10% of batters when facing the leadoff batter in the inning this season — 2nd highest in MLB.

The Twins have allowed 5.47 runs per game (405/74) on the road this season — 2nd highest in MLB.

Twins pitchers have an ERA of 5.22 (633.0 IP) on the road this season — 3rd highest in MLB.

Twins pitchers have allowed innings of 3+ runs in 7% of innings played this season — tied for 3rd highest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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