• The Guardians are -145 favorites vs the White Sox
• Guardians vs White Sox Over / Under today: 7.5 Runs
• Guardians / White Sox TV Channel: GDTV | CHSN

The Cleveland Guardians (-145) visit Rate Field to take on the Chicago White Sox (+120) on August 7, 2026. First pitch is scheduled for 7:40 pm in Chicago, IL.

This season, the Guardians are 57-59 against the spread (ATS), while the White Sox are 65-46 ATS.

Guardians vs White Sox Starting Pitchers Today:

• Guardians starting pitcher: Parker Messick 8-6, 2.59 ERA
• White Sox starting pitcher: Jordan Hicks 1-1, 3.34 ERA

Guardians vs. White Sox Odds, Run Line, Over/Under & Moneyline

Guardians vs White Sox Prediction for Today’s Game

Based on recent trends the model predicts the Guardians will win Friday‘s MLB game with 55.8% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Guardians vs White Sox and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Guardians players for Friday‘s game, looking at profitable historical betting trends:

Best Guardians Player Prop Bets Today:

• Patrick Bailey has hit the Home Runs Over in 3 of his last 9 games (+18.00 Units / 200% ROI)
• Jose Ramirez has hit the RBIs Under in 18 of his last 20 games (+13.80 Units / 31% ROI)
• Steven Kwan has hit the Hits Over in 18 of his last 20 games (+13.60 Units / 33% ROI)
• Rhys Hoskins has hit the Singles Under in 21 of his last 25 away games (+12.35 Units / 24% ROI)
• Jose Ramirez has hit the Walks Under in 14 of his last 15 away games (+12.05 Units / 40% ROI)

And here are some favorite MLB player prop bets for White Sox players for Friday‘s game, looking at profitable historical betting trends:

Best White Sox Player Prop Best Bets Today:

• Chase Meidroth has hit the Home Runs Over in 2 of his last 5 games at home (+19.00 Units / 380% ROI)
• Munetaka Murakami has hit the Total Bases Over in 15 of his last 20 games at home (+11.10 Units / 45% ROI)
• Munetaka Murakami has hit the RBIs Under in 17 of his last 20 games (+10.65 Units / 24% ROI)
• Munetaka Murakami has hit the Hits Over in 16 of his last 20 games at home (+9.20 Units / 29% ROI)
• Randal Grichuk has hit the Singles Under in 19 of his last 25 games at home (+9.00 Units / 21% ROI)

Guardians Best Bets Today:

• The Cleveland Guardians have hit the Game Total Under in 26 of their last 40 away games (+10.25 Units / 23% ROI)
• The Cleveland Guardians have hit the Team Total Under in 27 of their last 45 away games (+6.95 Units / 13% ROI)
• The Cleveland Guardians have hit the 1st Five Innings (F5) Moneyline in 21 of their last 50 away games (+5.40 Units / 10% ROI)
• The Cleveland Guardians have hit the 1st Five Innings (F5) Team Total Under in 23 of their last 40 games (+5.35 Units / 11% ROI)
• The Cleveland Guardians have hit the Moneyline in 19 of their last 35 away games (+5.15 Units / 14% ROI)

White Sox Best Bets Today:

• The Chicago White Sox have hit the Moneyline in 30 of their last 45 games at home (+15.55 Units / 30% ROI)
• The Chicago White Sox have covered the Run Line in 29 of their last 45 games at home (+12.10 Units / 19% ROI)
• The Chicago White Sox have hit the Game Total Over in 23 of their last 40 games at home (+5.35 Units / 12% ROI)
• The Chicago White Sox have hit the 1st Five Innings (F5) Team Total Under in 13 of their last 21 games at home (+4.30 Units / 17% ROI)
• The Chicago White Sox have hit the 1st Five Innings (F5) Moneyline in 10 of their last 22 games (+4.15 Units / 16% ROI)

Guardians Against the Spread (ATS) Record

Against the spread this season, the Guardians are 55-60 against the Run Line (-8.55 Units / -5.7% ROI).

• 57-59 when betting on the Moneyline for -6.6 Units / -4.74% ROI
• 55-61 when betting on the total runs Over for -11.6 Units / -9.16% ROI
• 61-55 when betting on the total runs Under for -0.2 Units / -0.16% ROI

White Sox Against the Spread (ATS) Record

Against the spread this season, the White Sox are 65-46 against the Run Line (+5.65 Units / 3.47% ROI).

• 59-55 when betting on the Moneyline for +11.35 Units / 9.3% ROI
• 64-48 when betting on the total runs Over for +11.5 Units / 9.21% ROI
• 48-64 when betting on the total runs Under for -22.75 Units / -18.06% ROI

White Sox vs Guardians Home Run Prop Bets Today

White Sox vs Guardians Total Hits Prop Bets Today

White Sox vs Guardians Strikeout Prop Bets Today

Guardians Keys to the Game vs. the White Sox

The Guardians were 33-4 (.868) when they had 10 or more hits in the 2025 season — 2nd best in MLB; League Avg: .743.

The Guardians were 71-2 (.973) when leading entering the 7th inning in the 2024 season — best in MLB; League Avg: .856.

The Guardians were just 3-61 (.047) when trailing entering the 8th inning in the 2024 season — 2nd lowest in MLB; League Avg: .100.

The Guardians were 24-2 (.923) when they had 5 or more XBH in the 2025 season — 2nd best in MLB; League Avg: .799.

White Sox Keys to the Game vs. the Guardians

The White Sox were just 3-58 (.049) when allowing 10 or more hits in the 2024 season — lowest in MLB; League Avg: .250.

The White Sox were just 41-121 (.253) in the 2024 season — lowest in MLB; League Avg: .500.

The White Sox were just 33-23 (.589) when leading entering the 7th inning in the 2024 season — lowest in MLB; League Avg: .856.

The White Sox were just 0-79 (.000) when trailing entering the 7th inning in the 2024 season — lowest in MLB; League Avg: .143.

Guardians Hitting Stats & Trends

The Guardians are batting just .216 on the road this season — lowest in MLB.

Guardians hitters have an OPS of just .691 (3,034 PA’s) against RHP this season — 4th lowest in MLB.

Guardians hitters have an OPS of just .659 (1,365 PA’s) in innings 7-9 this season — lowest in MLB.

Guardians hitters are slugging just .379 against RHP this season — 3rd lowest in MLB.

White Sox Hitting Stats & Trends

White Sox hitters have struck out in 24% of their PA’s against RHP this season — tied for 5th highest in MLB.

White Sox hitters have 55 extra-base hits out of 114 total hits (48%) when facing the starting pitcher for the 3rd time in a game this season — best in MLB.

White Sox hitters are slugging .611 on the first pitch of at-bats this season — 4th best in MLB.

The White Sox are batting just .241 on fastballs this season — tied for lowest in MLB.

Guardians Pitching Stats & Trends

Guardians pitchers have a strikeout rate of 25% this season — 3rd best in MLB.

Opponents have a miss rate of 27% against Guardians pitchers this season — 4th best in MLB.

Guardians pitchers have a strikeout rate of 25% with runners in scoring position this season — 2nd best in MLB.

Guardians pitchers have a strikeout rate of 27% in late innings this season — 2nd best in MLB.

White Sox Pitching Stats & Trends

The White Sox have won 53% of home games in which their opponents scored first this season — 2nd highest in MLB.

The White Sox pitchers have allowed their opponents to score first in just 37% of their games on the road this season — 3rd lowest in MLB.

White Sox pitchers have walked 10% of batters when facing the leadoff batter in the inning this season — tied for 4th highest in MLB.

White Sox pitchers have an ERA of 2.96 (267.1 IP) against division opponents this season — tied for best in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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