Guardians vs White Sox Prediction, Odds & Player Prop Bets Today – MLB, Jul 12

Chicago White Sox's watches the flight of the ball during a baseball game against the Los Angeles Angels Wednesday, May 31, 2023, in Chicago.
(AP Photo/Charles Rex Arbogast)
  • The Guardians are -160 favorites vs the White Sox
  • Guardians vs White Sox Over / Under today: 9 Runs
  • Guardians / White Sox TV Channel: GDTV | CHSN

The Cleveland Guardians (-160) visit Rate Field to take on the Chicago White Sox (+135) on Saturday, July 12, 2025. First pitch is scheduled for 4:10pm EDT in Chicago, IL, IL.

This season, the Guardians are 44-49 against the spread (ATS), while the White Sox are 52-43 ATS.

Guardians vs White Sox Starting Pitchers Today:

  • Guardians starting pitcher: Tanner Bibee 4-9, 4.39 ERA
  • White Sox starting pitcher: Sean Burke 4-8, 4.47 ERA

Guardians vs. White Sox Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Guardians-1.5 +105O 9 -125-160
White Sox +1.5 -125U 9 +105+135

Guardians vs White Sox Prediction for Today’s Game

Based on recent trends the model predicts the Guardians will win Saturday‘s MLB game with 57.6% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


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We’ve highlighted some favorite MLB player prop bets for Guardians players for Saturday‘s game, looking at profitable historical betting trends:

Best Guardians Player Prop Bets Today:

  • Angel Martinez has hit the Home Runs Over in 4 of his last 10 away games (+26.40 Units / 264% ROI)
  • Steven Kwan has hit the Hits Under in 16 of his last 25 games (+10.25 Units / 25% ROI)
  • Angel Martinez has hit the Total Bases Over in his last 8 games (+9.10 Units / 77% ROI)
  • Brayan Rocchio has hit the Singles Under in 13 of his last 15 games (+8.75 Units / 35% ROI)
  • Jose Ramirez has hit the Runs Under in 18 of his last 25 games (+7.95 Units / 23% ROI)

And here are some favorite MLB player prop bets for White Sox players for Saturday‘s game, looking at profitable historical betting trends:

Best White Sox Player Prop Best Bets Today:

  • Miguel Vargas has hit the RBIs Under in 18 of his last 20 games (+12.75 Units / 29% ROI)
  • Miguel Vargas has hit the Hits Under in 13 of his last 20 games (+9.60 Units / 42% ROI)
  • Miguel Vargas has hit the Hits Runs and RBIs Under in 15 of his last 20 games (+8.45 Units / 33% ROI)
  • Miguel Vargas has hit the Total Bases Under in 13 of his last 20 games (+8.10 Units / 34% ROI)
  • Luis Robert has hit the Home Runs Over in 3 of his last 10 games (+7.80 Units / 78% ROI)
  • The Cleveland Guardians have hit the Game Total Under in 35 of their last 56 games (+14.15 Units / 23% ROI)
  • The Cleveland Guardians have hit the Team Total Under in 54 of their last 90 games (+14.04 Units / 13% ROI)
  • The Cleveland Guardians have covered the Run Line in 19 of their last 26 away games (+11.75 Units / 31% ROI)
  • The Cleveland Guardians have covered the 1st Five Innings (F5) Run Line in 13 of their last 19 away games (+6.75 Units / 30% ROI)
  • The Cleveland Guardians have hit the 1st Five Innings (F5) Team Total Over in 11 of their last 17 away games (+4.55 Units / 24% ROI)
  • The Chicago White Sox have covered the 1st Five Innings (F5) Run Line in 32 of their last 48 games at home (+13.45 Units / 23% ROI)
  • The Chicago White Sox have hit the 1st Five Innings (F5) Moneyline in 27 of their last 71 games (+9.00 Units / 12% ROI)
  • The Chicago White Sox have hit the Game Total Under in 34 of their last 61 games (+8.55 Units / 13% ROI)
  • The Chicago White Sox have hit the 1st Five Innings (F5) Team Total Under in 49 of their last 86 games (+8.19 Units / 8% ROI)
  • The Chicago White Sox have hit the Team Total Over in 22 of their last 35 games at home (+7.49 Units / 18% ROI)

Guardians Against the Spread (ATS) Record

Against the spread this season, the Guardians are 49-43 against the Run Line (-1.15 Units / -0.9% ROI).

  • 44-49 when betting on the Moneyline for -4.1 Units / -3.87% ROI
  • 39-50 when betting on the total runs Over for -14.75 Units / -14.6% ROI
  • 50-39 when betting on the total runs Under for +7.25 Units / 7% ROI

White Sox Against the Spread (ATS) Record

Against the spread this season, the White Sox are 52-43 against the Run Line (+2.4 Units / 2.08% ROI).

  • 32-63 when betting on the Moneyline for -15.76 Units / -16.5% ROI
  • 40-49 when betting on the total runs Over for -14.45 Units / -13.74% ROI
  • 49-40 when betting on the total runs Under for +4.85 Units / 4.67% ROI

White Sox vs Guardians Home Run Prop Bets Today

Over Under
Jose Ramirez (CLE) 0.5 +290 0.5 -350
Kyle Manzardo (CLE) 0.5 +360 0.5 -500
Miguel Vargas (CWS) 0.5 +375 0.5 -500
Daniel Schneemann (CLE) 0.5 +400 0.5 -550
Bo Naylor (CLE) 0.5 +400 0.5 -550

White Sox vs Guardians Total Hits Prop Bets Today

Over Under
Jose Ramirez (CLE) 0.5 -275 0.5 +200
Chase Meidroth (CWS) 0.5 -220 0.5 +165
Andrew Benintendi (CWS) 0.5 -210 0.5 +155
Mike Tauchman (CWS) 0.5 -200 0.5 +150
Angel Martínez (CLE) 0.5 -190 0.5 +140

White Sox vs Guardians RBI Prop Bets Today

Over Under
Jose Ramirez (CLE) 0.5 +105 0.5 -140
Kyle Manzardo (CLE) 0.5 +135 0.5 -175
Andrew Benintendi (CWS) 0.5 +155 0.5 -200
Miguel Vargas (CWS) 0.5 +160 0.5 -220
Carlos Santana (CLE) 0.5 +180 0.5 -235

White Sox vs Guardians Strikeout Prop Bets Today

Over Under
Tanner Bibee (CLE) 5.5 +115 5.5 -150
Sean Burke (CWS) 4.5 +120 4.5 -155

Right-handed hitters have a line drive rate of just 17% (27/163) against Tanner Bibee this season — 2nd lowest among qualified SPs in MLB; League Avg: 24% — 98th Percentile.

Opponents have a chase percentage of just 28% (82/298) against Tanner Bibee with two-strikes this season — lowest among qualified SPs in MLB; League Avg: 39% — first Percentile.

Tanner Bibee has a strike rate of just 55% when ahead in the count (fifth lowest)– seventh Percentile and 74% when behind in the count this season (tied for third highest among qualified SPs)– 96th Percentile.

61% of Tanner Bibee’s strikeouts are on pitches in the zone this season — 7th highest among qualified SPs in MLB; League Avg: 49% — 91st Percentile.

White Sox Starting Pitcher Stats & Trends

Sean Burke has walked 14% of left-handed batters since last season — 3rd highest in MLB among starting pitchers with at least 101 total IP; League Avg: 9% — second Percentile.

Sean Burke has a first-pitch strike rate of just 57% (233/407) this season — tied for 7th lowest in MLB among starting pitchers with at least 37 total IP; League Avg: 63% — seventh Percentile.

Sean Burke has allowed a slugging percentage of .500 (98 Total Bases / 196 ABs) on non-fastballs this season — 5th highest in MLB among starting pitchers with at least 37 total IP; League Avg: .369 — fourth Percentile.

Sean Burke has allowed an OPS of 1.046 (82 PA’s) when going through the lineup the third time in a game this season — 3rd highest in MLB among starting pitchers with at least 37 total IP; League Avg: .745 — second Percentile.

Guardians Keys to the Game vs. the White Sox

The Guardians are 20-0 (.952) when they’ve had 10 or more hits this season — best in MLB; League Avg: .748.

The Guardians are just 6-103 (.055) when trailing entering the 8th inning since last season — 2nd lowest in MLB; League Avg: .097.

The Guardians are 107-5 (.955) when leading entering the 7th inning since last season — best in MLB; League Avg: .863.

The Guardians were 82-0 (1.000) when leading entering the 9th inning in the 2024 season — best in MLB; League Avg: .949.

White Sox Keys to the Game vs. the Guardians

The White Sox are just 59-31 (.656) when leading entering the 7th inning since last season — lowest in MLB; League Avg: .863.

The White Sox are just 6-116 (.049) when allowing 5 or more runs since last season — lowest in MLB; League Avg: .197.

The White Sox are just 27-7 (.794) when leading entering the 8th inning this season — lowest in MLB; League Avg: .906.

The White Sox are just 5-85 (.056) when allowing 10 or more hits since last season — lowest in MLB; League Avg: .250.

The Guardians are batting just .216 against LHP this season — 2nd lowest in MLB; League Avg: .241.

The Guardians are batting just .190 in righty-righty matchups this season — lowest in MLB; League Avg: .246.

The Guardians are batting just .295 in hitter’s counts since last season — lowest in MLB; League Avg: .336.

Guardians hitters have an OPS of just .614 (1,087 PA’s) against LHP this season — 2nd lowest in MLB; League Avg: .694.

The White Sox have a winning percentage of just 23% on the road this season — lowest in MLB; League Avg: 45%.

White Sox hitters have an OPS of just .626 (9,342 PA’s) since last season — lowest in MLB; League Avg: .713.

White Sox hitters are slugging just .342 since last season — lowest in MLB; League Avg: .400.

White Sox hitters have an OBP of just .284 (6,976 PA’s) against RHP since last season — lowest in MLB; League Avg: .314.

Guardians pitchers have walked 13% of batters this month (11 games) — highest in MLB; League Avg: 8%.

Opponents had a groundball batting average of just .207 against Guardians pitchers with runners on base in the 2024 season — best in MLB; League Avg: .262.

Opponents have a chase percentage of just 25% against the Guardians pitchers this season — lowest in MLB; League Avg: 28%.

The Guardians allowed 0.87 runs per game (140/161) in late innings in the 2024 season — best in MLB; League Avg: 1.29.

The White Sox have won just 12% of games in which their opponents scored first since last season — lowest in MLB; League Avg: 32%.

White Sox pitchers have won only 7% of games in which they have allowed their opponent to score in three different innings since last season — lowest in MLB; League Avg: 26%.

In games when their opponents have scored three or more runs in an inning, the White Sox won just 4% of the time since last season — lowest in MLB; League Avg: 24%.

The White Sox have won just 5% of road games in which their opponents scored first since last season — lowest in MLB; League Avg: 26%.

More MLB Reading:


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Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.